- The Cubs are -118 favorites vs the Red Sox
- Cubs vs Red Sox Over / Under today: 6.5 Runs
- Cubs / Red Sox TV Channel: NESN | MARQ
The Chicago Cubs (-118) visit Fenway Park to take on the Boston Red Sox (-102) on September 25, 2026. First pitch is scheduled for 1:05 pm in Boston, MA.
This season, the Cubs are 88-71 against the spread (ATS), while the Red Sox are 74-81 ATS.
Cubs vs Red Sox Starting Pitchers Today:
- Cubs starting pitcher: Clay Holmes 6-8, 3.26 ERA
- Red Sox starting pitcher: Alec Gamboa 1-0, 1.17 ERA
Cubs vs. Red Sox Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| Cubs | -1.5 +165 | O 6.5 -118 | -118 |
| Red Sox | +1.5 -200 | U 6.5 -102 | -102 |
Cubs vs Red Sox Prediction for Today’s Game
Based on recent trends the model predicts the Cubs will win Friday‘s MLB game with 55.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for Cubs players for Friday‘s game, looking at profitable historical betting trends:
Best Cubs Player Prop Bets Today:
- Michael Conforto has hit the Home Runs Over in 4 of his last 9 away games (+16.30 Units / 181% ROI)
- Ian Happ has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+12.20 Units / 46% ROI)
- Alex Bregman has hit the Walks Over in 8 of his last 10 away games (+11.70 Units / 117% ROI)
- Ian Happ has hit the Hits Over in 19 of his last 25 games (+11.35 Units / 30% ROI)
- Ian Happ has hit the Total Bases Over in 18 of his last 25 games (+10.65 Units / 32% ROI)
And here are some favorite MLB player prop bets for Red Sox players for Friday‘s game, looking at profitable historical betting trends:
Best Red Sox Player Prop Best Bets Today:
- Adley Rutschman has hit the Walks Under in 19 of his last 20 games (+17.30 Units / 46% ROI)
- Trevor Story has hit the Total Bases Over in 20 of his last 25 games (+15.90 Units / 46% ROI)
- Ceddanne Rafaela has hit the Runs Under in his last 15 games (+15.00 Units / 57% ROI)
- Trevor Story has hit the Hits Over in 21 of his last 25 games (+14.35 Units / 32% ROI)
- Mickey Gasper has hit the Home Runs Over in 3 of his last 8 games at home (+14.10 Units / 176% ROI)
Cubs Best Bets Today:
- The Chicago Cubs have covered the Run Line in 30 of their last 45 away games (+18.05 Units / 33% ROI)
- The Chicago Cubs have hit the Team Total Over in 31 of their last 45 away games (+14.90 Units / 28% ROI)
- The Chicago Cubs have hit the Game Total Over in 28 of their last 45 games (+12.65 Units / 25% ROI)
- The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 18 of their last 30 games (+9.95 Units / 23% ROI)
- The Chicago Cubs have hit the Moneyline in 28 of their last 45 away games (+9.35 Units / 17% ROI)
Red Sox Best Bets Today:
- The Boston Red Sox have hit the Game Total Under in 16 of their last 18 games (+13.90 Units / 70% ROI)
- The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 22 of their last 30 games (+13.75 Units / 39% ROI)
- The Boston Red Sox have hit the Team Total Under in 12 of their last 14 games (+9.75 Units / 56% ROI)
- The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in 23 of their last 40 games at home (+4.65 Units / 10% ROI)
- The Boston Red Sox have hit the Moneyline in 26 of their last 40 games at home (+3.25 Units / 5% ROI)
Cubs Against the Spread (ATS) Record
Against the spread this season, the Cubs are 75-82 against the Run Line (-3.1 Units / -1.68% ROI).
- 88-71 when betting on the Moneyline for -4.15 Units / -1.91% ROI
- 88-67 when betting on the total runs Over for +14.95 Units / 8.52% ROI
- 67-88 when betting on the total runs Under for -29.1 Units / -16.66% ROI
Red Sox Against the Spread (ATS) Record
Against the spread this season, the Red Sox are 74-81 against the Run Line (-5.55 Units / -2.85% ROI).
- 85-74 when betting on the Moneyline for -8.2 Units / -3.89% ROI
- 70-85 when betting on the total runs Over for -24.2 Units / -13.76% ROI
- 85-70 when betting on the total runs Under for +8.15 Units / 4.68% ROI
Cubs Keys to the Game vs. the Red Sox
The Cubs are 30-35 (.462) when allowing 2 or more home runs this season — best in MLB.
The Cubs are 6-63 (.087) when trailing entering the 9th inning this season — 2nd best in MLB.
The Cubs are 35-19 (.648) vs bottom 10 scoring offenses this season Today, they face the Red Sox (21st in runs scored).
The Cubs are 48-6 (.889) when they’ve had 10 or more hits this season — 2nd best in MLB.
Red Sox Keys to the Game vs. the Cubs
The Red Sox are 50-35 (.588) after a win this season — 4th best in MLB.
The Red Sox are 71-2 (.973) when leading entering the 8th inning this season — tied for 2nd best in MLB.
The Red Sox are 63-5 (.926) when leading entering the 7th inning this season — 3rd best in MLB.
The Red Sox are just 8-42 (.160) when allowing 5 or more runs this season — 4th lowest in MLB.
Cubs Hitting Stats & Trends
Cubs hitters have an OBP of .349 (1,642 PA’s) against LHP this season — best in MLB.
Cubs hitters have an OBP of .339 (6,268 PA’s) this season — tied for 2nd best in MLB.
Cubs hitters have an OBP of .368 (634 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.
Cubs hitters have an OPS of .796 (1,642 PA’s) against LHP this season — best in MLB.
Red Sox Hitting Stats & Trends
The Red Sox have a winning percentage of 57% on the road this season — 4th best in MLB.
Red Sox hitters have 134 extra-base hits out of 360 total hits (37%) against LHP this season — 3rd best in MLB.
Red Sox hitters are slugging .239 on pitches out of the zone this season — 4th best in MLB.
The Red Sox are batting .276 in lefty-lefty matchups this season — 2nd best in MLB.
Cubs Pitching Stats & Trends
Opponents have a groundball batting average of just .214 against Cubs pitchers with runners on base this season — best in MLB.
Cubs pitchers have picked-off 24 runners from first base this season — most in MLB.
Opponents have a groundball batting average of just .224 against Cubs pitchers this season — best in MLB.
The Cubs have won 41% of road games in which their opponents scored first this season — 3rd highest in MLB.
Red Sox Pitching Stats & Trends
Red Sox pitchers have walked 8% of batters this season — 3rd best in MLB.
Red Sox pitchers have allowed a run just 24% of the time after their offense scores this season — lowest in MLB.
Red Sox pitchers have walked 7% of batters when facing the leadoff batter in the inning this season — 5th best in MLB.
Red Sox pitchers have allowed three-ball counts to 18% of batters they faced (1,053/5,914 PA’s) this season — tied for 2nd lowest in MLB.
More MLB Reading:
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