• The Guardians are -190 favorites vs the Nationals
• Nationals vs Guardians Over / Under today: 7.5 Runs
• Nationals / Guardians TV Channel: GDTV | NATV

The Washington Nationals (+155) visit Progressive Field to take on the Cleveland Guardians (-190) on May 27, 2026. First pitch is scheduled for 1:10 pm in Cleveland, OH.

This season, the Nationals are 29-27 against the spread (ATS), while the Guardians are 29-28 ATS.

Nationals vs Guardians Starting Pitchers Today:

• Nationals starting pitcher: Miles Mikolas 1-3, 6.13 ERA
• Guardians starting pitcher: Gavin Williams 7-3, 3.23 ERA

Nationals vs. Guardians Odds, Run Line, Over/Under & Moneyline

Nationals vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Wednesday‘s MLB game with 59.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Nationals vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Nationals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Bets Today:

• Jacob Young has hit the Home Runs Over in 4 of his last 9 games (+44.00 Units / 489% ROI)
• Miles Mikolas has hit the Hits Allowed Under in 18 of his last 25 games (+10.25 Units / 35% ROI)
• James Wood has hit the Walks Over in 17 of his last 25 away games (+9.80 Units / 35% ROI)
• Daylen Lile has hit the Runs Over in 10 of his last 15 games (+9.20 Units / 61% ROI)
• Luis Garcia has hit the Hits Under in 14 of his last 25 games (+8.31 Units / 27% ROI)

And here are some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Angel Martinez has hit the Home Runs Over in 4 of his last 7 games at home (+25.90 Units / 370% ROI)
• Patrick Bailey has hit the Hits Runs and RBIs Under in 18 of his last 25 games (+12.65 Units / 43% ROI)
• Steven Kwan has hit the Walks Over in 8 of his last 10 games at home (+12.05 Units / 121% ROI)
• Steven Kwan has hit the Hits Under in 13 of his last 20 games (+10.95 Units / 45% ROI)
• Steven Kwan has hit the Total Bases Under in 15 of his last 20 games (+9.10 Units / 30% ROI)

Nationals Best Bets Today:

• The Washington Nationals have hit the Moneyline in 28 of their last 50 away games (+21.25 Units / 43% ROI)
• The Washington Nationals have covered the Run Line in 28 of their last 35 away games (+18.90 Units / 39% ROI)
• The Washington Nationals have hit the 1st Five Innings (F5) Team Total Over in 35 of their last 50 games (+17.55 Units / 29% ROI)
• The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 29 of their last 40 away games (+17.25 Units / 37% ROI)
• The Washington Nationals have hit the 1st Five Innings (F5) Moneyline in 21 of their last 40 away games (+16.25 Units / 40% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have covered the Run Line in 27 of their last 50 games at home (+9.65 Units / 17% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games at home (+9.10 Units / 19% ROI)
• The Cleveland Guardians have hit the Team Total Under in their last 8 games (+8.10 Units / 92% ROI)
• The Cleveland Guardians have hit the Moneyline in 14 of their last 20 games (+7.05 Units / 27% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 26 of their last 45 games (+6.45 Units / 13% ROI)

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are 36-19 against the Run Line (+11.25 Units / 14.22% ROI).

• 29-27 when betting on the Moneyline for +11.8 Units / 20.77% ROI
• 35-18 when betting on the total runs Over for +15.5 Units / 25.14% ROI
• 18-35 when betting on the total runs Under for -20.3 Units / -32.95% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 29-28 against the Run Line (+2.15 Units / 3.04% ROI).

• 32-25 when betting on the Moneyline for +6.4 Units / 9.29% ROI
• 28-29 when betting on the total runs Over for -3.4 Units / -5.45% ROI
• 29-28 when betting on the total runs Under for -1.9 Units / -3% ROI

Guardians vs Nationals Home Run Prop Bets Today

Guardians vs Nationals Total Hits Prop Bets Today

Guardians vs Nationals Strikeout Prop Bets Today

Nationals Keys to the Game vs. the Guardians

The Nationals are just 0-23 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .053.

The Nationals are 19-11 (.633) on the road this season — 4th best in MLB; League Avg: .476.

The Nationals are 23-4 (.852) when allowing 4 or fewer runs this season — 4th best in MLB; League Avg: .719.

The Nationals are just 16-52 (.232) when their opponents score in the first inning since the 2025 season — 2nd lowest in MLB; League Avg: .362.

Guardians Keys to the Game vs. the Nationals

The Guardians are 9-4 (.692) when tied entering the 7th inning this season — 5th best in MLB; League Avg: .500.

The Guardians are 22-1 (.957) when leading entering the 7th inning this season — 3rd best in MLB; League Avg: .864.

The Guardians are 10-1 (.909) when they’ve had 10 or more hits this season — 5th best in MLB; League Avg: .757.

The Guardians are 16-8 (.667) after a loss this season — 2nd best in MLB; League Avg: .469.

Nationals Hitting Stats & Trends

The Nationals have scored 1.95 runs per game (109/56) in late innings this season — best in MLB.

The Nationals are batting .270 against LHP this season — 3rd best in MLB.

The Nationals are batting just .184 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

The Nationals are hitting just .177 against pitchers who have thrown at least 80 pitches in the game this season — 2nd lowest in MLB.

Guardians Hitting Stats & Trends

The Guardians are hitting just .173 against pitchers who have thrown at least 80 pitches in the game this season — lowest in MLB.

Guardians hitters have a groundball batting average of just .198 this season — lowest in MLB.

Guardians hitters have struck out in just 19% of their PA’s against LHP this season — 4th best in MLB.

9% of Guardians’ hitters plate appearances have lasted only one pitch (188/2,136 PA’s) this season — lowest in MLB.

Nationals Pitching Stats & Trends

Opponents have a miss rate of just 23% against Nationals pitchers this season — lowest in MLB.

Nationals pitchers have a strikeout rate of just 39% with two-strikes this season — 3rd lowest in MLB.

The Nationals have allowed 6.35 runs per game (165/26) at home this season — highest in MLB.

Nationals pitchers have an ERA of 4.73 (507.2 IP) this season — 4th highest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 35% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — 2nd best in MLB.

Guardians pitchers have struck out 27% of left-handed batters they faced this season — best in MLB.

Guardians pitchers have a strikeout rate of 26% with runners in scoring position this season — tied for best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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