- Get betting predictions and analysis for Orioles vs. Blue Jays on Opening Day.
- First pitch is scheduled for 3:07 p.m. ET at Rogers Centre.
- My Orioles vs. Blue Jays prediction is to take the over.
As part of MLB’s 14-game schedule on Opening Day, the Toronto Blue Jays will host the Baltimore Orioles at 3:07 p.m. ET on Thursday, March 27, at the Rogers Centre.
The Baltimore Orioles aim for a deep playoff run in 2025 following back-to-back trips to the postseason without a victory. The Toronto Blue Jays can relate after losing in the American League wild-card round in 2022 and 2023 before finishing fifth in the division last year.
The betting lines for this matchup between division foes have moved in favor of the home team. The Blue Jays opened at +100, and the Orioles started with a -120 moneyline price.
Here’s a look at the latest MLB odds and my Orioles vs. Blue Jays prediction ahead of Opening Day.
Orioles vs. Blue Jays Odds: Thursday, March 27
Orioles vs. Blue Jays Opening Day Starting Pitchers
Zach Eflin will get the start for the Orioles on Opening Day. This title would have likely gone to Grayson Rodriguez, but he’s been shut down after a cortisone shot in his elbow.
José Berríos will get his third Opening Day start in the past four years for the Blue Jays.
- Orioles starting pitcher: Zach Eflin
- Blue Jays starting pitcher: José Berríos
Orioles vs. Blue Jays Prediction for Opening Day
Based on the latest MLB betting lines, I like the over as my Orioles vs. Blue Jays prediction for Opening Day.
There isn’t a total at the BetMGM online sportsbook at this time, but it’s worth considering the over at the right price. These two teams scored 126 total runs in 13 head-to-head meetings last year, averaging 9.69 per game.
The Orioles are an obvious over team this year due to the combination of a potent lineup and underwhelming rotation. Baltimore’s offense ranked third in all of baseball last year with a wRC+ of 115, trailing the Los Angeles Dodgers and New York Yankees.
The Blue Jays also appear due for some positive regression in what could be Vladimir Guerrero Jr.’s final season in the lineup. They scored 671 runs last year after averaging 789 across the three previous campaigns.
While it’s unclear what the total will be, the over is worth a look for this game.
How to Watch Orioles vs. Blue Jays on Opening Day
- Date: Thursday, March 27
- Time: 3:07 p.m. ET
- Location: Rogers Centre
- TV info: MASN2, Sportsnet (MLB TV)
Orioles 2025 Schedule
Blue Jays 2025 Schedule
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