• The Cardinals are -150 favorites vs the Padres
• Padres vs Cardinals Over / Under today: 8.5 Runs
• Padres / Cardinals TV Channel: CATV | PDTV

The San Diego Padres (+125) visit Busch Stadium to take on the St. Louis Cardinals (-150) on June 15, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Padres are 37-33 against the spread (ATS), while the Cardinals are 43-25 ATS.

Padres vs Cardinals Starting Pitchers Today:

• Padres starting pitcher: Lucas Giolito 2-1, 4.36 ERA
• Cardinals starting pitcher: Dustin May 4-6, 4.27 ERA

Padres vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Padres vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Monday‘s MLB game with 57.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Monday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Manny Machado has hit the Singles Under in 21 of his last 25 games (+15.60 Units / 47% ROI)
• Rodolfo Duran has hit the Home Runs Over in 2 of his last 4 away games (+12.90 Units / 322% ROI)
• Fernando Tatis Jr. has hit the Hits Over in 19 of his last 25 games (+12.60 Units / 28% ROI)
• Xander Bogaerts has hit the Total Bases Under in 19 of his last 25 away games (+12.30 Units / 35% ROI)
• Will Wagner has hit the Runs Under in his last 9 games (+9.00 Units / 49% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Alec Burleson has hit the Home Runs Over in 6 of his last 9 games (+21.60 Units / 240% ROI)
• Alec Burleson has hit the RBIs Over in 12 of his last 20 games at home (+11.70 Units / 58% ROI)
• Alec Burleson has hit the Singles Over in 13 of his last 15 games at home (+10.40 Units / 53% ROI)
• Alec Burleson has hit the Runs Over in his last 9 games (+10.00 Units / 108% ROI)
• Jordan Walker has hit the Hits Over in 9 of his last 10 games (+9.45 Units / 51% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Under in 32 of their last 50 games (+11.90 Units / 20% ROI)
• The San Diego Padres have hit the Game Total Over in 6 of their last 7 games (+4.90 Units / 62% ROI)
• The San Diego Padres have hit the Moneyline in 17 of their last 30 away games (+4.55 Units / 14% ROI)
• The San Diego Padres have covered the Run Line in 13 of their last 21 away games (+3.90 Units / 14% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 23 of their last 40 games (+3.55 Units / 7% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 33 of their last 50 games (+13.25 Units / 22% ROI)
• The St. Louis Cardinals have covered the Run Line in 30 of their last 45 games (+10.85 Units / 17% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 games (+9.95 Units / 18% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 11 of their last 13 games (+9.15 Units / 57% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 11 of their last 13 games (+9.10 Units / 59% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 36-32 against the Run Line (-0.3 Units / -0.32% ROI).

• 37-33 when betting on the Moneyline for +1 Units / 1.18% ROI
• 31-37 when betting on the total runs Over for -9.75 Units / -12.59% ROI
• 37-31 when betting on the total runs Under for +3.15 Units / 4.11% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 43-25 against the Run Line (+9.4 Units / 9.32% ROI).

• 38-31 when betting on the Moneyline for +11.6 Units / 16.04% ROI
• 31-34 when betting on the total runs Over for -6.15 Units / -8.14% ROI
• 34-31 when betting on the total runs Under for -0.3 Units / -0.39% ROI

Cardinals vs Padres Home Run Prop Bets Today

Cardinals vs Padres Total Hits Prop Bets Today

Cardinals vs Padres Strikeout Prop Bets Today

Padres Keys to the Game vs. the Cardinals

The Padres are 23-1 (.958) when scoring 5 or more runs this season — best in MLB; League Avg: .792.

The Padres are 4-31 (.114) when trailing entering the 9th inning this season — tied for 2nd best in MLB; League Avg: .055.

The Padres are 8-3 (.727) when tied entering the 7th inning this season — 3rd best in MLB; League Avg: .500.

The Padres are 28-1 (.966) when leading entering the 8th inning this season — 5th best in MLB; League Avg: .893.

Cardinals Keys to the Game vs. the Padres

The Cardinals are 3-27 (.100) when trailing entering the 9th inning this season — tied for 4th best in MLB; League Avg: .055.

The Cardinals are 16-5 (.762) when they’ve scored in the first inning this season — tied for 4th best in MLB; League Avg: .645.

The Cardinals are 12-92 (.115) when trailing entering the 8th inning since the 2025 season — tied for 5th best in MLB; League Avg: .095.

The Cardinals are just 30-94 (.242) when scoring 4 or fewer runs since the 2025 season — 4th lowest in MLB; League Avg: .282.

Padres Hitting Stats & Trends

Padres hitters have an OBP of just .284 (624 PA’s) against LHP this season — lowest in MLB.

The Padres are batting just .207 against starting pitchers this season — lowest in MLB.

The Padres are batting just .219 this season — lowest in MLB.

Padres hitters have an OPS of just .658 (2,558 PA’s) this season — lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — best in MLB.

Cardinals hitters have 99 extra-base hits out of 335 total hits (just 30%) against starting pitchers this season — lowest in MLB.

Cardinals hitters are slugging .256 on pitches out of the zone this season — 4th best in MLB.

Cardinals hitters have put 44% of their swings in play in lefty-lefty matchups this season — highest in MLB.

Padres Pitching Stats & Trends

Padres pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — 3rd highest in MLB.

Opponents have a groundball rate of 46% against Padres pitchers this season — 2nd highest in MLB.

Opponents have a groundball batting average of .296 against Padres pitchers with runners on base this season — 3rd highest in MLB.

Opponents have a miss rate of 27% against Padres pitchers this season — 5th best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 4th highest in MLB.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — tied for 4th lowest in MLB.

Cardinals pitchers have allowed an average Exit Velocity of 90.2 MPH (1,801 batted balls) this season — highest in MLB.

Cardinals pitchers have a strikeout rate of just 19% with runners in scoring position this season — 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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