• The Padres are -135 favorites vs the Diamondbacks
• Padres vs Diamondbacks Over / Under today: 15.5 Runs
• Padres / Diamondbacks TV Channel: DBTV | PDTV

The San Diego Padres (-135) visit Estadio Alfredo Harp Helu to take on the Arizona Diamondbacks (+110) on April 26, 2026. First pitch is scheduled for 4:05 pm in Mexico City, Mexico.

This season, the Padres are 18-8 against the spread (ATS), while the Diamondbacks are 18-8 ATS.

Padres vs Diamondbacks Starting Pitchers Today:

• Padres starting pitcher: Michael King 3-1, 2.25 ERA
• Diamondbacks starting pitcher: Ryne Nelson 1-2, 6.86 ERA

Padres vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

Padres vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Sunday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Diamondbacks and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Sunday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Jackson Merrill has hit the Singles Under in 19 of his last 25 away games (+13.35 Units / 48% ROI)
• Manny Machado has hit the Total Bases Under in 20 of his last 25 away games (+13.00 Units / 36% ROI)
• Jackson Merrill has hit the Hits Under in 16 of his last 25 away games (+11.05 Units / 32% ROI)
• Xander Bogaerts has hit the Home Runs Over in 2 of his last 9 away games (+10.90 Units / 121% ROI)
• Manny Machado has hit the Hits Runs and RBIs Under in 18 of his last 25 away games (+10.90 Units / 38% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Sunday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

• Ildemaro Vargas has hit the Home Runs Over in 3 of his last 9 games at home (+24.50 Units / 272% ROI)
• Ildemaro Vargas has hit the Hits Over in 18 of his last 20 games (+16.00 Units / 44% ROI)
• Jose Fernandez has hit the Singles Over in 13 of his last 15 games (+11.65 Units / 72% ROI)
• Ildemaro Vargas has hit the Total Bases Over in 14 of his last 20 games (+10.65 Units / 42% ROI)
• Jose Fernandez has hit the Hits Runs and RBIs Over in 12 of his last 15 games (+9.60 Units / 57% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Moneyline in 16 of their last 19 games (+13.20 Units / 53% ROI)
• The San Diego Padres have hit the Team Total Under in 15 of their last 20 away games (+9.40 Units / 41% ROI)
• The San Diego Padres have covered the Run Line in 22 of their last 35 games (+9.20 Units / 20% ROI)
• The San Diego Padres have hit the Game Total Under in 14 of their last 20 away games (+8.40 Units / 38% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 8 of their last 9 away games (+7.10 Units / 65% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Team Total Over in 33 of their last 50 games (+15.70 Units / 28% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 28 of their last 50 games at home (+11.20 Units / 17% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 18 of their last 24 games at home (+11.00 Units / 38% ROI)
• The Arizona Diamondbacks have covered the Run Line in 18 of their last 25 games (+9.20 Units / 26% ROI)
• The Arizona Diamondbacks have hit the Game Total Over in 26 of their last 45 games (+8.40 Units / 17% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 16-9 against the Run Line (+5.3 Units / 14.99% ROI).

• 18-8 when betting on the Moneyline for +9.7 Units / 29.35% ROI
• 10-14 when betting on the total runs Over for -5.15 Units / -18.13% ROI
• 14-10 when betting on the total runs Under for +3 Units / 10.4% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 18-8 against the Run Line (+8.2 Units / 22.4% ROI).

• 14-12 when betting on the Moneyline for +3 Units / 10.26% ROI
• 15-10 when betting on the total runs Over for +4.1 Units / 14.24% ROI
• 10-15 when betting on the total runs Under for -6.2 Units / -21.83% ROI

Diamondbacks vs Padres Home Run Prop Bets Today

Diamondbacks vs Padres Total Hits Prop Bets Today

Diamondbacks vs Padres Strikeout Prop Bets Today

Padres Keys to the Game vs. the Diamondbacks

The Padres are 2-8 (.200) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .049.

The Padres are 18-8 (.692) this season — best in MLB; League Avg: .500.

The Padres are 9-0 (1.000) when they’ve had 10 or more hits this season — tied for best in MLB; League Avg: .773.

The Padres are 14-62 (.184) when trailing entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .126.

Diamondbacks Keys to the Game vs. the Padres

The Diamondbacks are just 70-21 (.769) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .874.

The Diamondbacks are just 77-15 (.837) when leading entering the 8th inning since the 2025 season — tied for 2nd lowest in MLB; League Avg: .907.

The Diamondbacks are 3-5 (.375) when trailing entering the 7th inning this season — best in MLB; League Avg: .137.

The Diamondbacks are just 80-7 (.920) when leading entering the 9th inning since the 2025 season — 3rd lowest in MLB; League Avg: .956.

Padres Hitting Stats & Trends

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 2nd best in MLB.

Padres hitters have struck out in just 18% of their PA’s against LHP since the 2024 season — best in MLB.

Padres hitters have an OPS of just .593 (508 PA’s) against starting pitchers this season — lowest in MLB.

Padres hitters have a swing rate of 63% with two-strikes since the 2025 season — highest in MLB.

Diamondbacks Hitting Stats & Trends

The Diamondbacks are batting .300 against LHP this season — best in MLB.

Diamondbacks hitters have an OBP of just .284 (665 PA’s) against RHP this season — lowest in MLB.

The Diamondbacks are batting .396 in lefty-lefty matchups this season — best in MLB.

Diamondbacks hitters have chased 48% of pitches out of the zone with two-strikes this season — highest in MLB.

Padres Pitching Stats & Trends

Opponents have a miss rate of 28% against Padres pitchers this season — 2nd best in MLB.

Opponents have a groundball rate of 46% against Padres pitchers this season — tied for 4th highest in MLB.

The Padres have allowed 0.92 runs per game (24/26) in late innings this season — 2nd best in MLB.

Padres pitchers have a strikeout rate of 44% with two-strikes since the 2025 season — tied for 4th best in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have an ERA of 7.40 (45.0 IP) over the past seven days (5 games) — highest in MLB.

Diamondbacks pitchers have walked 5% of batters when facing the leadoff batter in the inning this season — 2nd best in MLB.

Opponents have a miss rate of just 24% against Diamondbacks pitchers this season — 5th lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 20% this season — tied for 4th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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