• The Dodgers are -220 favorites vs the Padres
• Padres vs Dodgers Over / Under today: 8 Runs
• Padres / Dodgers TV Channel: SNLA | PDTV

The San Diego Padres (+180) visit Dodger Stadium to take on the Los Angeles Dodgers (-220) on September 23, 2026. First pitch is scheduled for 10:10 pm in Los Angeles, CA.

This season, the Padres are 87-70 against the spread (ATS), while the Dodgers are 69-87 ATS.

Padres vs Dodgers Starting Pitchers Today:

• Padres starting pitcher: Robbie Ray 13-8, 3.63 ERA
• Dodgers starting pitcher: Yoshinobu Yamamoto 14-8, 2.53 ERA

Padres vs. Dodgers Odds, Run Line, Over/Under & Moneyline

Padres vs Dodgers Prediction for Today’s Game

Based on recent trends the model predicts the Dodgers will win Wednesday‘s MLB game with 71.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Luis Campusano has hit the Runs Under in 18 of his last 20 away games (+15.10 Units / 40% ROI)
• Fernando Tatis Jr. has hit the Singles Under in 18 of his last 25 away games (+13.95 Units / 54% ROI)
• Fernando Tatis Jr. has hit the Home Runs Over in 5 of his last 10 games (+13.20 Units / 132% ROI)
• Manny Machado has hit the Hits Under in 15 of his last 25 away games (+12.80 Units / 45% ROI)
• Dustin Harris has hit the Hits Runs and RBIs Over in 15 of his last 20 away games (+10.75 Units / 46% ROI)

And here are some favorite MLB player prop bets for Dodgers players for Wednesday‘s game, looking at profitable historical betting trends:

Best Dodgers Player Prop Best Bets Today:

• Teoscar Hernández has hit the Singles Over in 17 of his last 20 games at home (+16.70 Units / 83% ROI)
• Will Smith has hit the Home Runs Over in 4 of his last 5 games at home (+15.10 Units / 302% ROI)
• Teoscar Hernández has hit the Hits Over in 18 of his last 20 games at home (+14.60 Units / 38% ROI)
• Teoscar Hernández has hit the Hits Runs and RBIs Over in 16 of his last 20 games (+11.70 Units / 49% ROI)
• Kyle Tucker has hit the Walks Over in 15 of his last 25 games at home (+11.60 Units / 46% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Over in 29 of their last 45 away games (+11.80 Units / 23% ROI)
• The San Diego Padres have hit the Moneyline in 33 of their last 50 games (+11.70 Units / 17% ROI)
• The San Diego Padres have hit the Game Total Over in 12 of their last 13 games (+10.90 Units / 75% ROI)
• The San Diego Padres have covered the Run Line in 24 of their last 40 games (+10.80 Units / 21% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 31 of their last 50 games (+9.40 Units / 16% ROI)

Dodgers Best Bets Today:

• The Los Angeles Dodgers have hit the Moneyline in their last 11 games at home (+11.00 Units / 39% ROI)
• The Los Angeles Dodgers have hit the 1st Five Innings (F5) Team Total Over in 20 of their last 30 games at home (+9.00 Units / 25% ROI)
• The Los Angeles Dodgers have covered the Run Line in 11 of their last 15 games (+7.10 Units / 39% ROI)
• The Los Angeles Dodgers have hit the Team Total Over in 10 of their last 13 games at home (+6.15 Units / 36% ROI)
• The Los Angeles Dodgers have hit the Game Total Over in 14 of their last 24 games at home (+4.20 Units / 16% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 85-69 against the Run Line (+11.6 Units / 5.65% ROI).

• 87-70 when betting on the Moneyline for +10.25 Units / 5.27% ROI
• 74-78 when betting on the total runs Over for -11.8 Units / -6.8% ROI
• 78-74 when betting on the total runs Under for -2.8 Units / -1.63% ROI

Dodgers Against the Spread (ATS) Record

Against the spread this season, the Dodgers are 69-87 against the Run Line (-23.95 Units / -12.9% ROI).

• 97-60 when betting on the Moneyline for -13.85 Units / -4.48% ROI
• 72-81 when betting on the total runs Over for -17.3 Units / -9.99% ROI
• 81-72 when betting on the total runs Under for +1.9 Units / 1.1% ROI

Padres Keys to the Game vs. the Dodgers

The Padres are 62-8 (.886) when scoring 5 or more runs this season — 2nd best in MLB.

The Padres are 62-5 (.925) when leading entering the 7th inning this season — tied for 3rd best in MLB.

The Padres are 69-2 (.972) when leading entering the 8th inning this season — tied for 2nd best in MLB.

The Padres are 13-8 (.619) when tied entering the 7th inning this season — tied for 4th best in MLB.

Dodgers Keys to the Game vs. the Padres

The Dodgers are 26-19 (.578) when their opponents score in the first inning this season — best in MLB.

The Dodgers are 37-50 (.425) when scoring 4 or fewer runs this season — 2nd best in MLB.

The Dodgers are 41-16 (.719) vs bottom 10 scoring offenses this season Today, they face the Padres (18th in runs scored).

The Dodgers are 95-51 (.651) when allowing 5 or more extra base hits this season — 2nd best in MLB.

Padres Hitting Stats & Trends

Padres hitters have grounded into 121 double plays in 1,031 opportunities (12%) this season — highest in MLB.

Padres hitters are slugging .416 on the road this season — 3rd best in MLB.

Padres hitters are slugging .621 on the first pitch of at-bats this season — 2nd best in MLB.

Padres hitters have put just 34% of balls in play to the right side of the field this season — lowest in MLB.

Dodgers Hitting Stats & Trends

Dodgers hitters have an OBP of .349 (3,126 PA’s) on the road this season — best in MLB.

The Dodgers are batting .265 on the road this season — best in MLB.

Dodgers hitters have an OPS of .779 (3,126 PA’s) on the road this season — best in MLB.

Dodgers hitters have an OBP of .344 (4,132 PA’s) against RHP this season — 2nd best in MLB.

Padres Pitching Stats & Trends

Padres pitchers have a strikeout rate of 29% in close and late situations this season — 2nd best in MLB.

Padres pitchers have an ERA of 3.37 (716.0 IP) at home this season — 3rd best in MLB.

The Padres have allowed 3.65 runs per game (285/78) at home this season — 2nd best in MLB.

Padres pitchers have a strikeout rate of just 14% when going through the lineup the third time in a game this season — lowest in MLB.

Dodgers Pitching Stats & Trends

The Dodgers pitchers have allowed division opponents to score first in just 36% of their games this season — tied for lowest in MLB.

The Dodgers have allowed 3.55 runs per game (277/78) on the road this season — 2nd best in MLB.

Dodgers pitchers have won 37% of games in which they have allowed their opponent to score in three different innings this season — highest in MLB.

Dodgers pitchers have a strikeout rate of 46% with two-strikes this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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