• The Giants are -130 favorites vs the Padres
• Padres vs Giants Over / Under today: 7.5 Runs
• Padres / Giants TV Channel: NSBA | PDTV

The San Diego Padres (+110) visit Oracle Park to take on the San Francisco Giants (-130) on May 5, 2026. First pitch is scheduled for 9:45 pm in San Francisco, CA.

This season, the Padres are 20-14 against the spread (ATS), while the Giants are 15-19 ATS.

Padres vs Giants Starting Pitchers Today:

• Padres starting pitcher: Walker Buehler 1-2, 5.40 ERA
• Giants starting pitcher: Logan Webb 2-3, 4.30 ERA

Padres vs. Giants Odds, Run Line, Over/Under & Moneyline

Padres vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Tuesday‘s MLB game with 51.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Giants and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Tuesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Miguel Andujar has hit the Home Runs Over in 2 of his last 5 games (+12.50 Units / 250% ROI)
• Jake Cronenworth has hit the Total Bases Under in 18 of his last 25 games (+11.00 Units / 36% ROI)
• Fernando Tatis Jr. has hit the Runs Under in 15 of his last 20 games (+10.60 Units / 45% ROI)
• Jackson Merrill has hit the Singles Under in 15 of his last 20 away games (+10.15 Units / 46% ROI)
• Jake Cronenworth has hit the Hits Under in 16 of his last 25 games (+9.95 Units / 37% ROI)

And here are some favorite MLB player prop bets for Giants players for Tuesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Casey Schmitt has hit the Home Runs Over in 3 of his last 4 games at home (+15.50 Units / 388% ROI)
• Willy Adames has hit the Walks Under in 22 of his last 25 games (+15.35 Units / 29% ROI)
• Rafael Devers has hit the Runs Under in 17 of his last 20 games (+12.60 Units / 38% ROI)
• Heliot Ramos has hit the Total Bases Over in 15 of his last 20 games (+12.00 Units / 47% ROI)
• Willy Adames has hit the Hits Runs and RBIs Under in 16 of his last 20 games (+11.70 Units / 44% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Under in 17 of their last 22 away games (+11.40 Units / 45% ROI)
• The San Diego Padres have hit the Game Total Under in 15 of their last 22 away games (+8.30 Units / 34% ROI)
• The San Diego Padres have hit the Moneyline in 28 of their last 45 games (+8.25 Units / 14% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 11 away games (+6.75 Units / 49% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 19 of their last 40 games (+5.70 Units / 11% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the Team Total Over in 22 of their last 35 games at home (+7.40 Units / 18% ROI)
• The San Francisco Giants have hit the Moneyline in 7 of their last 9 games at home (+6.80 Units / 72% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 18 games at home (+5.85 Units / 30% ROI)
• The San Francisco Giants have hit the Game Total Under in 10 of their last 14 games (+5.60 Units / 36% ROI)
• The San Francisco Giants have covered the Run Line in 7 of their last 9 games at home (+4.60 Units / 38% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 18-15 against the Run Line (+0.65 Units / 1.43% ROI).

• 20-14 when betting on the Moneyline for +3.6 Units / 8.19% ROI
• 15-17 when betting on the total runs Over for -3.5 Units / -9.36% ROI
• 17-15 when betting on the total runs Under for +0.65 Units / 1.74% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 15-19 against the Run Line (-10.75 Units / -21.48% ROI).

• 14-21 when betting on the Moneyline for -6.45 Units / -17.13% ROI
• 14-18 when betting on the total runs Over for -5.65 Units / -14.71% ROI
• 18-14 when betting on the total runs Under for +2.55 Units / 6.61% ROI

Giants vs Padres Home Run Prop Bets Today

Giants vs Padres Total Hits Prop Bets Today

Giants vs Padres Strikeout Prop Bets Today

Padres Keys to the Game vs. the Giants

The Padres are 30-20 (.600) vs the top 10 runs allowed teams since the 2025 season Today, they face Giants (eighth in runs allowed).

The Padres are 9-6 (.600) on the road this season — 5th best in MLB; League Avg: .465.

The Padres are 13-1 (.929) when scoring 5 or more runs this season — 3rd best in MLB; League Avg: .783.

The Padres are 14-67 (.173) when trailing entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .128.

Giants Keys to the Game vs. the Padres

The Giants are just 0-18 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .057.

The Giants are just 10-4 (.714) when leading entering the 7th inning this season — tied for 2nd lowest in MLB; League Avg: .856.

The Giants are just 2-13 (.133) when allowing 5 or more runs this season — tied for 4th lowest in MLB; League Avg: .217.

The Giants are just 75-11 (.872) when leading entering the 8th inning since the 2025 season — tied for 5th lowest in MLB; League Avg: .906.

Padres Hitting Stats & Trends

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 2nd best in MLB.

Padres hitters have a swing rate of 63% with two-strikes since the 2025 season — highest in MLB.

Padres hitters struck out just 278 times in 1,617 PA’s (17%) against LHP in the 2024 season — best in MLB; League Avg: 23%.

Padres hitters are slugging just .185 on breaking pitches against LHP this season — tied for lowest in MLB.

Giants Hitting Stats & Trends

Giants hitters have drawn walks in 6% of their PA’s against RHP this season — lowest in MLB.

Giants hitters have an OBP of just .283 (861 PA’s) against RHP this season — lowest in MLB.

Giants hitters have drawn walks in 6% of their PA’s this season — lowest in MLB.

Giants hitters have drawn walks in 6% of their PA’s against LHP this season — lowest in MLB.

Padres Pitching Stats & Trends

Opponents have a miss rate of 27% against Padres pitchers this season — tied for 3rd best in MLB.

Opponents have a groundball rate of 47% against Padres pitchers this season — tied for 2nd highest in MLB.

Padres pitchers have walked 12% of batters over the past seven days (6 games) — 5th highest in MLB.

Padres pitchers have an ERA of 3.33 (912.0 IP) at home since the 2025 season — tied for 2nd best in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 47% against Giants pitchers this season — tied for 2nd highest in MLB.

Opponents had a groundball rate of 49% against Giants pitchers in the 2024 season — highest in MLB.

Giants pitchers have thrown at least two strikes in their first three pitches to 57% of opposing batters this season — lowest in MLB.

Giants pitchers have an ERA of 2.32 (62.0 IP) against division opponents this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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