• The Padres are -155 favorites vs the Giants
• Padres vs Giants Over / Under today: 8 Runs
• Padres / Giants TV Channel: ATV

The San Diego Padres (-155) visit Oracle Park to take on the San Francisco Giants (+125) on September 11, 2026. First pitch is scheduled for 10:15 pm in San Francisco, CA.

This season, the Padres are 78-68 against the spread (ATS), while the Giants are 72-73 ATS.

Padres vs Giants Starting Pitchers Today:

• Padres starting pitcher: Robbie Ray 11-8, 3.42 ERA
• Giants starting pitcher: Anthony Molina 3-0, 2.80 ERA

Padres vs. Giants Odds, Run Line, Over/Under & Moneyline

Padres vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Friday‘s MLB game with 57.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Giants and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Friday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Fernando Tatis Jr. has hit the Singles Under in 18 of his last 25 away games (+12.50 Units / 48% ROI)
• Luis Campusano has hit the Runs Under in 14 of his last 15 away games (+12.20 Units / 40% ROI)
• Luis Campusano has hit the Home Runs Over in 2 of his last 6 games (+11.60 Units / 193% ROI)
• Ty France has hit the Total Bases Over in 15 of his last 25 away games (+7.80 Units / 28% ROI)
• Jake Cronenworth has hit the Hits Under in 7 of his last 8 games (+7.70 Units / 94% ROI)

And here are some favorite MLB player prop bets for Giants players for Friday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Christian Koss has hit the Home Runs Over in 2 of his last 5 games (+18.00 Units / 360% ROI)
• Bryce Eldridge has hit the Total Bases Over in 16 of his last 20 games (+15.70 Units / 68% ROI)
• Bryce Eldridge has hit the RBIs Over in 9 of his last 10 games at home (+15.35 Units / 153% ROI)
• Bryce Eldridge has hit the Hits Over in 21 of his last 25 games (+14.20 Units / 32% ROI)
• Bryce Eldridge has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+13.90 Units / 52% ROI)

Padres Best Bets Today:

• The San Diego Padres have covered the Run Line in 29 of their last 50 games (+11.80 Units / 19% ROI)
• The San Diego Padres have hit the Team Total Over in 30 of their last 50 away games (+7.80 Units / 13% ROI)
• The San Diego Padres have hit the Moneyline in 28 of their last 45 games (+7.80 Units / 13% ROI)
• The San Diego Padres have hit the Game Total Under in 13 of their last 23 games (+4.25 Units / 17% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 9 of their last 15 games (+2.20 Units / 12% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 20 of their last 25 games (+14.95 Units / 49% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 20 of their last 25 games at home (+14.20 Units / 47% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 17 of their last 25 games at home (+12.70 Units / 42% ROI)
• The San Francisco Giants have hit the Team Total Over in 13 of their last 18 games (+7.20 Units / 34% ROI)
• The San Francisco Giants have hit the Moneyline in 23 of their last 40 games at home (+6.45 Units / 14% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 79-64 against the Run Line (+11.35 Units / 5.91% ROI).

• 78-68 when betting on the Moneyline for +4.2 Units / 2.39% ROI
• 64-77 when betting on the total runs Over for -20.7 Units / -12.85% ROI
• 77-64 when betting on the total runs Under for +7 Units / 4.37% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 72-73 against the Run Line (-19.3 Units / -9.51% ROI).

• 62-85 when betting on the Moneyline for -18.35 Units / -11.32% ROI
• 68-66 when betting on the total runs Over for -4.65 Units / -2.87% ROI
• 66-68 when betting on the total runs Under for -8.6 Units / -5.33% ROI

Padres Keys to the Game vs. the Giants

The Padres are 60-2 (.968) when leading entering the 8th inning this season — 4th best in MLB.

The Padres are 53-8 (.869) when scoring 5 or more runs this season — 4th best in MLB.

The Padres are 9-59 (.132) when trailing entering the 8th inning this season — 5th best in MLB.

The Padres are 36-19 (.655) vs the bottom 10 runs allowed teams this season Today, they face the Giants (23rd fewest runs allowed).

Giants Keys to the Game vs. the Padres

The Giants are just 2-62 (.031) when trailing entering the 7th inning this season — 2nd lowest in MLB.

The Giants are just 51-16 (.761) when leading entering the 7th inning this season — 3rd lowest in MLB.

The Giants are just 2-66 (.029) when trailing entering the 8th inning this season — tied for 2nd lowest in MLB.

The Giants are just 6-27 (.182) when allowing 2 or more home runs this season — tied for 2nd lowest in MLB.

Padres Hitting Stats & Trends

Padres hitters have grounded into 115 double plays in 957 opportunities (12%) this season — highest in MLB.

Padres hitters have put just 33% of balls in play to the right side of the field this season — lowest in MLB.

Padres hitters have an OPS of .748 (1,742 PA’s) in innings 7-9 this season — 4th best in MLB.

The Padres have won 93% of home games in which they have scored three or more runs in an inning this season — 2nd highest in MLB.

Giants Hitting Stats & Trends

The Giants are batting .259 with two outs this season — 2nd best in MLB.

Giants hitters are slugging .419 on the road this season — 2nd best in MLB.

The Giants are batting .251 on the road this season — 3rd best in MLB.

Giants hitters have drawn walks in 8% of their PA’s against RHP this season — 2nd lowest in MLB.

Padres Pitching Stats & Trends

Padres pitchers have allowed innings of 3+ runs in 4% of innings played this season — 2nd lowest in MLB.

The Padres pitchers have allowed their opponents to score first in 60% of their games at home this season — 4th highest in MLB.

Padres pitchers have a strikeout rate of 29% in close and late situations this season — 2nd best in MLB.

Padres pitchers have an ERA of 3.36 (688.0 IP) at home this season — 3rd best in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 46% against Giants pitchers this season — highest in MLB.

Giants pitchers have a strikeout rate of just 20% this season — 4th lowest in MLB.

The Giants have won just 5% of road games in which their opponents scored first this season — lowest in MLB.

Giants pitchers have walked 10% of batters this season — 5th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Padres vs Giants and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.