• The Padres are -150 favorites vs the Rockies
• Padres vs Rockies Over / Under today: 12 Runs
• Padres / Rockies TV Channel: ROTV | PDTV

The San Diego Padres (-150) visit Coors Field to take on the Colorado Rockies (+125) on April 22, 2026. First pitch is scheduled for 8:40 pm in Denver, CO.

This season, the Padres are 16-7 against the spread (ATS), while the Rockies are 15-9 ATS.

Padres vs Rockies Starting Pitchers Today:

• Padres starting pitcher: Walker Buehler 1-1, 4.59 ERA
• Rockies starting pitcher: Tomoyuki Sugano 1-1, 3.92 ERA

Padres vs. Rockies Odds, Run Line, Over/Under & Moneyline

Padres vs Rockies Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Wednesday‘s MLB game with 60.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Rockies and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Manny Machado has hit the Total Bases Under in 20 of his last 25 away games (+12.90 Units / 35% ROI)
• Manny Machado has hit the Hits Runs and RBIs Under in 18 of his last 25 away games (+11.45 Units / 42% ROI)
• Jackson Merrill has hit the Singles Under in 13 of his last 15 away games (+10.90 Units / 64% ROI)
• Xander Bogaerts has hit the Runs Under in 20 of his last 25 games (+10.10 Units / 21% ROI)
• Manny Machado has hit the Hits Under in 15 of his last 25 away games (+10.00 Units / 31% ROI)

And here are some favorite MLB player prop bets for Rockies players for Wednesday‘s game, looking at profitable historical betting trends:

Best Rockies Player Prop Best Bets Today:

• Kyle Karros has hit the Walks Over in 7 of his last 8 games at home (+10.70 Units / 134% ROI)
• Ezequiel Tovar has hit the Total Bases Under in 19 of his last 25 games at home (+10.70 Units / 31% ROI)
• Ezequiel Tovar has hit the Runs Under in 19 of his last 25 games at home (+10.25 Units / 27% ROI)
• Jordan Beck has hit the Hits Under in 8 of his last 10 games (+8.50 Units / 85% ROI)
• Hunter Goodman has hit the RBIs Under in 12 of his last 15 games at home (+7.55 Units / 30% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Moneyline in 27 of their last 40 games (+13.15 Units / 24% ROI)
• The San Diego Padres have hit the Team Total Under in 13 of their last 17 away games (+8.45 Units / 43% ROI)
• The San Diego Padres have hit the Game Total Under in 29 of their last 50 games (+8.10 Units / 15% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 10 of their last 18 games (+8.00 Units / 35% ROI)
• The San Diego Padres have covered the Run Line in 12 of their last 16 games (+7.90 Units / 36% ROI)

Rockies Best Bets Today:

• The Colorado Rockies have hit the Moneyline in 23 of their last 50 games at home (+9.10 Units / 18% ROI)
• The Colorado Rockies have covered the Run Line in 28 of their last 50 games at home (+9.00 Units / 16% ROI)
• The Colorado Rockies have hit the Team Total Under in 22 of their last 35 games (+8.15 Units / 20% ROI)
• The Colorado Rockies have hit the Game Total Under in 16 of their last 25 games (+6.25 Units / 23% ROI)
• The Colorado Rockies have covered the 1st Five Innings (F5) Run Line in 9 of their last 12 games at home (+6.05 Units / 44% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 14-8 against the Run Line (+4.25 Units / 13.18% ROI).

• 16-7 when betting on the Moneyline for +9.25 Units / 32.01% ROI
• 9-12 when betting on the total runs Over for -3.95 Units / -15.74% ROI
• 12-9 when betting on the total runs Under for +2.1 Units / 8.22% ROI

Rockies Against the Spread (ATS) Record

Against the spread this season, the Rockies are 15-9 against the Run Line (+5.35 Units / 18.48% ROI).

• 9-15 when betting on the Moneyline for +0.45 Units / 1.88% ROI
• 9-15 when betting on the total runs Over for -7.7 Units / -28.79% ROI
• 15-9 when betting on the total runs Under for +5.25 Units / 20.15% ROI

Rockies vs Padres Home Run Prop Bets Today

Rockies vs Padres Total Hits Prop Bets Today

Rockies vs Padres Strikeout Prop Bets Today

Padres Keys to the Game vs. the Rockies

The Padres are 11-4 (.733) after a win this season — tied for best in MLB; League Avg: .536.

The Padres are 13-1 (.929) when allowing 4 or fewer runs this season — 2nd best in MLB; League Avg: .722.

The Padres are 29-6 (.829) when they’ve hit 2 or more home runs since the 2025 season — best in MLB; League Avg: .699.

The Padres are 16-7 (.696) this season — tied for best in MLB; League Avg: .500.

Rockies Keys to the Game vs. the Padres

The Rockies were just 40-96 (.294) when allowing 5 or more extra base hits in the 2025 season — lowest in MLB; League Avg: .535.

The Rockies are just 52-134 (.280) since the 2025 season — lowest in MLB; League Avg: .500.

The Rockies are just 34-98 (.258) after a loss since the 2025 season — lowest in MLB; League Avg: .481.

The Rockies are just 48-108 (.308) when allowing 5 or more extra base hits since the 2025 season — lowest in MLB; League Avg: .534.

Padres Hitting Stats & Trends

Padres hitters struck out in just 18% of their PA’s against LHP in the 2025 season — best in MLB.

Padres hitters struck out in just 19% of their PA’s in the 2025 season — 3rd best in MLB.

Padres hitters have struck out in just 18% of their PA’s against LHP since the 2024 season — best in MLB.

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 2nd best in MLB.

Rockies Hitting Stats & Trends

Rockies hitters had an OBP of just .259 (2,886 PA’s) on the road in the 2025 season — lowest in MLB.

Rockies hitters have an OBP of just .264 (3,384 PA’s) on the road since the 2025 season — lowest in MLB.

Rockies hitters have an OPS of just .600 (3,384 PA’s) on the road since the 2025 season — lowest in MLB.

Rockies hitters had an OPS of just .589 (2,886 PA’s) on the road in the 2025 season — lowest in MLB.

Padres Pitching Stats & Trends

Padres pitchers have a strikeout rate of 28% over the past seven days (6 games) — best in MLB.

Opponents have a miss rate of 29% against Padres pitchers this season — 2nd best in MLB.

Padres pitchers have a strikeout rate of 26% this season — 2nd best in MLB.

Padres pitchers had a strikeout rate of 45% with two-strikes in the 2025 season — 4th best in MLB.

Rockies Pitching Stats & Trends

Rockies pitchers had a strikeout rate of just 17% in the 2025 season — lowest in MLB.

Rockies pitchers have a strikeout rate of just 17% since the 2025 season — lowest in MLB.

Rockies pitchers had a strikeout rate of just 36% with two-strikes in the 2025 season — lowest in MLB.

The Rockies allowed 3.94 runs per game (638/162) in the first 5 innings in the 2025 season — highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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