• The Red Sox are -155 favorites vs the Twins
• Twins vs Red Sox Over / Under today: 7.5 Runs
• Twins / Red Sox TV Channel: TWTV | NESN | ESUN

The Minnesota Twins (+125) visit Fenway Park to take on the Boston Red Sox (-155) on May 22, 2026. First pitch is scheduled for 7:10 pm in Boston, MA.

This season, the Twins are 23-27 against the spread (ATS), while the Red Sox are 20-27 ATS.

Twins vs Red Sox Starting Pitchers Today:

• Twins starting pitcher: Connor Prielipp 1-2, 2.84 ERA
• Red Sox starting pitcher: Payton Tolle 2-2, 2.10 ERA

Twins vs. Red Sox Odds, Run Line, Over/Under & Moneyline

Twins vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Friday‘s MLB game with 56.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Twins vs Red Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Twins players for Friday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

• Ryan Kreidler has hit the Home Runs Over in 3 of his last 8 games (+27.50 Units / 344% ROI)
• Josh Bell has hit the Runs Under in 21 of his last 25 games (+14.10 Units / 32% ROI)
• Josh Bell has hit the Walks Under in 14 of his last 15 games (+12.15 Units / 39% ROI)
• Victor Caratini has hit the Hits Under in 10 of his last 15 games (+8.90 Units / 59% ROI)
• Victor Caratini has hit the Hits Runs and RBIs Under in 15 of his last 20 games (+8.80 Units / 32% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Friday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

• Jarren Duran has hit the Home Runs Over in 2 of his last 4 games (+10.80 Units / 270% ROI)
• Willson Contreras has hit the Runs Under in 13 of his last 15 games at home (+10.15 Units / 46% ROI)
• Wilyer Abreu has hit the Walks Under in his last 10 games (+10.00 Units / 46% ROI)
• Willson Contreras has hit the Hits Runs and RBIs Under in 12 of his last 15 games at home (+9.05 Units / 53% ROI)
• Caleb Durbin has hit the Singles Under in 15 of his last 20 games at home (+8.45 Units / 33% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the Team Total Over in 31 of their last 50 games (+9.35 Units / 16% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 away games (+8.00 Units / 17% ROI)
• The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 15 of their last 22 games (+7.40 Units / 27% ROI)
• The Minnesota Twins have hit the Game Total Over in 23 of their last 40 games (+7.35 Units / 17% ROI)
• The Minnesota Twins have covered the Run Line in 9 of their last 11 games (+7.00 Units / 45% ROI)

Red Sox Best Bets Today:

• The Boston Red Sox have hit the Team Total Under in 29 of their last 40 games at home (+17.05 Units / 37% ROI)
• The Boston Red Sox have hit the Game Total Under in 22 of their last 30 games at home (+15.40 Units / 47% ROI)
• The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 45 games at home (+11.90 Units / 21% ROI)
• The Boston Red Sox have covered the Run Line in 13 of their last 23 games (+5.95 Units / 20% ROI)
• The Boston Red Sox have hit the Moneyline in 4 of their last 5 games (+3.00 Units / 55% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 27-23 against the Run Line (-4.45 Units / -6.17% ROI).

• 23-27 when betting on the Moneyline for -2.75 Units / -5.14% ROI
• 27-19 when betting on the total runs Over for +5.85 Units / 10.57% ROI
• 19-27 when betting on the total runs Under for -10.65 Units / -19.49% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 20-27 against the Run Line (-6.65 Units / -11.2% ROI).

• 22-27 when betting on the Moneyline for -10.95 Units / -18.08% ROI
• 21-27 when betting on the total runs Over for -8.9 Units / -16.48% ROI
• 27-21 when betting on the total runs Under for +3.85 Units / 7.14% ROI

Red Sox vs Twins Home Run Prop Bets Today

Red Sox vs Twins Total Hits Prop Bets Today

Red Sox vs Twins Strikeout Prop Bets Today

Twins Keys to the Game vs. the Red Sox

The Twins are just 0-23 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .055.

The Twins are just 0-20 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .106.

The Twins are just 2-18 (.100) when allowing 5 or more runs this season — tied for 3rd lowest in MLB; League Avg: .207.

The Twins are just 9-12 (.429) vs bottom 10 scoring offenses this season Today, they face the Red Sox (29th in runs scored).

Red Sox Keys to the Game vs. the Twins

The Red Sox are 20-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .894.

The Red Sox are just 0-24 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .055.

The Red Sox are just 2-15 (.118) when allowing 10 or more hits this season — tied for 5th lowest in MLB; League Avg: .245.

The Red Sox are just 6-15 (.286) vs top 10 scoring offenses this season Today, they face the Twins (10th in runs scored).

Twins Hitting Stats & Trends

The Twins are batting just .199 with two outs this season — 2nd lowest in MLB.

Twins hitters have a 54% QAB rate with runners in scoring position this season — best in MLB.

The Twins are batting .281 when facing the starting pitcher for the 3rd time in a game this season — 4th best in MLB.

Twins hitters have put just 31% of their swings in play on the first pitch of at-bats this season — 2nd lowest in MLB.

Red Sox Hitting Stats & Trends

Red Sox hitters are slugging just .329 at home this season — tied for 2nd lowest in MLB.

Red Sox hitters are slugging just .354 against RHP this season — lowest in MLB.

Red Sox hitters have an OPS of just .680 (1,839 PA’s) this season — 5th lowest in MLB.

Red Sox hitters have an OPS of just .661 (1,413 PA’s) against RHP this season — 3rd lowest in MLB.

Twins Pitching Stats & Trends

Opponents have a groundball rate of just 40% against Twins pitchers this season — 3rd lowest in MLB.

Twins pitchers have a strikeout rate of just 17% in late innings this season — lowest in MLB.

Opponents have a miss rate of just 23% against Twins pitchers this season — 3rd lowest in MLB.

Twins pitchers have a strikeout rate of just 17% in close and late situations this season — lowest in MLB.

Red Sox Pitching Stats & Trends

Red Sox pitchers have walked 5% of batters when facing the leadoff batter in the inning this season — best in MLB.

The Red Sox have allowed 0.84 runs per game (41/49) in late innings this season — best in MLB.

Opponents have a groundball batting average of just .217 against Red Sox pitchers this season — 4th best in MLB.

Opponents have a groundball batting average of just .203 against Red Sox pitchers with runners on base this season — best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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