- The Rams are -3.5 point favorites vs the 49ers
- Total (Over/Under): 48.5 points
- Watch this game on NFLX
The San Francisco 49ers (0-0-0) visit Melbourne Cricket Ground to take on the Los Angeles Rams (0-0-0) on Sep. 10. Kickoff is scheduled for 8:35 pm in Melbourne, Australia.
The Rams are betting favorites in this matchup, with the spread sitting at -3.5 (-110).
The 49ers vs. Rams Over/Under is 48.5 total points for the game.
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49ers vs. Rams Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| 49ers | +3.5 -108 | 48.5 -110 | +170 |
| Rams | -3.5 -110 | 48.5 -108 | -200 |
49ers vs. Rams Prediction
The winning team model predicts the Rams will win this game with 61.4% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
49ers vs Rams Spread Prediction
Based on recent against-the-spread trends, the model predicts the Rams will cover the spread with 59.9% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:
Best 49ers Player Prop Bets Today
- Christian McCaffrey has hit the Longest Rush Under in 13 of his last 18 games (+7.45 Units / 35% ROI)
- Deebo Samuel has hit the Receptions Under in 9 of his last 11 games (+6.85 Units / 55% ROI)
- Jake Tonges has hit the Receptions Over in his last 5 games (+5.55 Units / 98% ROI)
- Kyle Juszczyk has hit the Longest Reception Over in 9 of his last 12 games (+5.35 Units / 38% ROI)
- Demarcus Robinson has hit the Receptions Over in 5 of his last 6 games (+5.25 Units / 77% ROI)
And here are some top NFL player prop bets for Rams players for this matchup, looking at profitable historical betting trends:
Best Rams Player Prop Best Bets Today
- Matthew Stafford has hit the TD Passes Over in 13 of his last 19 games (+8.65 Units / 40% ROI)
- Colby Parkinson has hit the Receiving Yards Over in 9 of his last 10 games (+7.80 Units / 68% ROI)
- Kyren Williams has hit the Carries Under in 12 of his last 16 games (+7.70 Units / 42% ROI)
- Puka Nacua has hit the Rushing Yards Under in 10 of his last 12 games (+7.45 Units / 50% ROI)
- Matthew Stafford has hit the Interceptions Under in 13 of his last 17 games (+6.60 Units / 28% ROI)
First Touchdown Scorer Bet for Rams vs 49ers
| Player Name | 1st TD Odds |
|---|---|
| Kyren Williams | +475 |
| Christian McCaffrey | +500 |
| Puka Nacua | +650 |
| Davante Adams | +800 |
| Blake Corum | +825 |
Anytime Touchdown Scorer Bet for Rams vs 49ers
| Player Name | Anytime TD Odds |
|---|---|
| Christian McCaffrey | -140 |
| Kyren Williams | -130 |
| Puka Nacua | +105 |
| Davante Adams | +130 |
| Blake Corum | +150 |
Receiving Props: Total Receiving Yards for Rams vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Puka Nacua | 90.5 -115 | 90.5 -115 |
| Davante Adams | 50.5 -115 | 50.5 -115 |
| Mike Evans | 50.5 -115 | 50.5 -115 |
| Christian McCaffrey | 39.5 -115 | 39.5 -115 |
| De'Zhaun Stribling | 34.5 -111 | 34.5 -118 |
Rushing Props: Total Rushing Yards for Rams vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Christian McCaffrey | 59.5 -115 | 59.5 -115 |
| Kyren Williams | 54.5 -115 | 54.5 -115 |
| Blake Corum | 43.5 -120 | 43.5 -111 |
| Brock Purdy | 18.5 -120 | 18.5 -110 |
49ers Best Bets:
- The San Francisco 49ers have hit the Moneyline in 14 of their last 21 games (+10.50 Units / 29% ROI)
- The San Francisco 49ers have hit the 3Q Game Total Over in 13 of their last 16 games (+9.20 Units / 46% ROI)
- The San Francisco 49ers have hit the 1H Game Total Over in 14 of their last 21 games (+7.15 Units / 30% ROI)
- The San Francisco 49ers have covered the Spread in 13 of their last 21 games (+5.40 Units / 23% ROI)
- The San Francisco 49ers have hit the 1H Team Total Over in 8 of their last 11 away games (+4.85 Units / 39% ROI)
Rams Best Bets:
- The Los Angeles Rams have hit the Team Total Over in 16 of their last 21 games (+10.15 Units / 41% ROI)
- The Los Angeles Rams have hit the 2H Game Total Over in 7 of their last 8 games (+5.75 Units / 61% ROI)
- The Los Angeles Rams have hit the 4Q Game Total Over in 9 of their last 12 games (+5.70 Units / 42% ROI)
- The Los Angeles Rams have hit the 4Q Moneyline in 8 of their last 17 games (+5.41 Units / 18% ROI)
- The Los Angeles Rams have hit the 2H Moneyline in 11 of their last 17 games (+5.35 Units / 14% ROI)
San Francisco 49ers: Keys to the Game vs. the Los Angeles Rams
The 49ers are 13-5 (.722) when allowing an average of less than 5 yards on first down (9th-best in NFL) and 5-11 (.312) when allowing an average of more than 5 yards on first down since the 2024 season (9th-lowest in NFL).
The 49ers were undefeated (5-0) when allowing less than 10 rushes of four or more yards last season — T-best in NFL; League Avg: .718.
The 49ers were 5-1 (.833) when within 7 points at the two minute warning last season — best in NFL; League Avg: .496.
The 49ers were undefeated (10-0) when leading at the end of the third quarter last season — T-best in NFL; League Avg: .839.
Los Angeles Rams: Keys to the Game vs. the San Francisco 49ers
The Rams were 10-2 (.833) when not throwing an interception last season — T-10th-best in NFL. The 49ers intercepted 6 passes last season — T-2nd-fewest in NFL.
The Rams were 10-4 (.714) when allowing less than 3 sacks last season — 10th-best in NFL. The 49ers averaged just 1.2 sacks per game over that time span — lowest in NFL.
The Rams were 10-4 (.714) when allowing less than 3 sacks last season — 10th-best in NFL; League Avg: .576.
The Rams were 7-1 (.875) when leading at the end of first quarter last season — T-5th-best in NFL; League Avg: .698.
Additional Matchup Notes for San Francisco 49ers vs. Los Angeles Rams
The Rams were successful on 50.7% of plays they ran last season — best in NFL. The 49ers allowed a success rate of 47.4% last season — 2nd-highest in NFL.
The Rams were successful on 51.6% of rush attempts with motion last season — best in NFL. The 49ers allowed a success rate of 48.1% on rush attempts against motion last season — 2nd-highest in NFL.
The Rams were successful on 56.0% of pass attempts on their opponent’s side of the field last week — 4th-best in NFL. The 49ers allowed a success rate of 66.7% on pass attempts on their own side of the field last week — T-4th-highest in NFL.
49ers RBs averaged just 1.6 yards after contact per carry last season — 2nd-lowest in NFL. The Rams allowed just 1.5 yards after contact per carry to RBs last season — best in NFL.
The 49ers averaged 0.63 epa per play against open coverage in the last 4 weeks of the regular season — 2nd-best in NFL. The Rams allowed 0.66 epa per play with open coverage in the last 4 weeks of the regular season — 3rd-highest in NFL.
The 49ers averaged 0.34 epa per play on play action passes in the last 4 weeks of the regular season — 3rd-best in NFL. The Rams allowed 0.30 epa per play on play action passes in the last 4 weeks of the regular season — 3rd-highest in NFL.
San Francisco 49ers Offense: Important Stats
The 49ers ran 57% of their plays in their opponent’s territory last season — best in NFL; League Avg: 48%.
The 49ers ran successful plays on 62% of pass attempts on first read passes last season — best in NFL; League Avg: 52%.
The 49ers ran successful plays on 56% of pass attempts in the 2nd half last season — best in NFL; League Avg: 46%.
The 49ers converted late downs on 23 of 260 plays (9%) with 7-10 yards to go last season — 2nd-best in NFL; League Avg: 6%.
Los Angeles Rams Offense: Important Stats
The Rams threw 2.7 TD passes per game (46/17) last season — best in NFL; League Avg: 1.5.
The Rams ran successful plays on 50% of plays in the 4th quarter last season — best in NFL; League Avg: 41%.
The Rams ran successful plays on 22% of rush attempts against a base rush last season — worst in NFL; League Avg: 48%.
The Rams averaged 13.5 yards per play against a light rush last season — best in NFL; League Avg: 6.7.
San Francisco 49ers Defense: Important Stats
The 49ers defense averaged a sack every 30.2 pass attempts (604 Pass Attempts/20 Sacks) last season — worst attempts per sack rate in NFL; League Avg: 14.6.
The 49ers defense allowed 17.6 yards per play with a light rush last season — worst in NFL; League Avg: 6.7.
The 49ers defense allowed a third down conversion rate of 34% open coverage last season — best in NFL; League Avg: 52%.
The 49ers defense allowed successful plays on 72% of plays with a stacked front last season — worst in NFL; League Avg: 46%.
Los Angeles Rams Defense: Important Stats
The Rams defense allowed 0.78 epa per play with a stacked front last season — worst in NFL; League Avg: 0.07.
The Rams defense allowed 8 rushing TDs last season — fewest in NFL.
The Rams defense allowed 8 rushing TDs on 431 carries (53.9 Carries Per TD) last season — best Carries Per TD rate in NFL; League Avg: 27.8.
The Rams defense allowed 0.26 epa per play open coverage last season — 3rd-best in NFL; League Avg: 0.39.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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