49ers vs Seahawks Prediction, Odds & Best Prop Bets – NFL, Week 5

• The Seahawks are -3 point favorites vs the 49ers
• Total (Over/Under): 47 points
• Watch this game on FOX

The San Francisco 49ers (4-0-0) visit Lumen Field to take on the Seattle Seahawks (3-1-0) on Oct. 11. Kickoff is scheduled for 4:25 pm in Seattle, WA.

The Seahawks are betting favorites in this matchup, with the spread sitting at -3 (-105).

The 49ers vs. Seahawks Over/Under is 47 total points for the game.

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49ers vs. Seahawks Odds, Spread, Over/Under

49ers vs. Seahawks Prediction

The winning team model predicts the Seahawks will win this game with 52.9% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

49ers vs Seahawks Spread Prediction

Based on recent against-the-spread trends, the model predicts the Seahawks will cover the spread with 51.7% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:

Best 49ers Player Prop Bets Today

• Brock Purdy has hit the Longest Rush Over in 10 of his last 13 games (+6.75 Units / 45% ROI)
• Deebo Samuel has hit the Receptions Under in 11 of his last 15 games (+6.50 Units / 37% ROI)
• Brock Purdy has hit the Rushing Yards Over in 10 of his last 13 games (+6.40 Units / 42% ROI)
• Kyle Juszczyk has hit the Receptions Over in 8 of his last 13 games (+6.15 Units / 40% ROI)
• Kyle Juszczyk has hit the Longest Reception Over in 9 of his last 13 games (+4.20 Units / 28% ROI)

And here are some top NFL player prop bets for Seahawks players for this matchup, looking at profitable historical betting trends:

Best Seahawks Player Prop Best Bets Today

• Jaxon Smith-Njigba has hit the Receptions Over in 13 of his last 18 games (+6.65 Units / 31% ROI)
• Elijah Arroyo has hit the Receptions Under in his last 6 games (+6.40 Units / 73% ROI)
• Emanuel Wilson has hit the Longest Rush Under in 11 of his last 15 games (+6.35 Units / 36% ROI)
• Rashid Shaheed has hit the Receiving Yards Under in 13 of his last 19 games (+6.20 Units / 29% ROI)
• AJ Barner has hit the Receptions Under in 12 of his last 18 games (+5.35 Units / 23% ROI)

49ers Best Bets:

• The San Francisco 49ers have hit the Moneyline in 15 of their last 21 games (+11.25 Units / 24% ROI)
• The San Francisco 49ers have covered the Spread in 14 of their last 21 games (+7.50 Units / 33% ROI)
• The San Francisco 49ers have hit the 1H Game Total Over in 9 of their last 11 away games (+6.60 Units / 53% ROI)
• The San Francisco 49ers have hit the 3Q Game Total Over in 13 of their last 18 games (+6.45 Units / 28% ROI)
• The San Francisco 49ers have hit the Team Total Over in 13 of their last 20 games (+4.90 Units / 21% ROI)

Seahawks Best Bets:

• The Seattle Seahawks have hit the Moneyline in 16 of their last 21 games (+8.75 Units / 15% ROI)
• The Seattle Seahawks have hit the 1Q Moneyline in 12 of their last 21 games (+8.34 Units / 24% ROI)
• The Seattle Seahawks have hit the 3Q Moneyline in 11 of their last 18 games (+7.95 Units / 24% ROI)
• The Seattle Seahawks have covered the Spread in 12 of their last 21 games (+5.40 Units / 23% ROI)
• The Seattle Seahawks have covered the 2H Spread in 11 of their last 18 games (+3.80 Units / 19% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 3-1 (+1.9 Units / 43.18% ROI).

• 49ers are 4-0 when betting on the Moneyline for +4.7 Units / 29.65% ROI
• 49ers are 2-2 when betting the Over for -0.2 Units / -4.55% ROI
• 49ers49ers49ers are 2-2 when betting the Under for -0.2 Units / -4.55% ROI

Seahawks Against the Spread (ATS) Record

Against the spread this NFL season, the Seahawks are 1-1 (-0.1 Units / -2.25% ROI).

• Seahawks are 3-1 when betting on the Moneyline for -0.9 Units / -8.22% ROI
• Seahawks are 2-2 when betting the Over for -0.2 Units / -4.55% ROI
• Seahawks are 2-2 when betting the Under for -0.2 Units / -4.55% ROI

San Francisco 49ers: Keys to the Game vs. the Seattle Seahawks

The 49ers are 10-1 (.909) when forcing 1 or more turnovers since the 2025 season — best in NFL. The Seahawks have turned the ball over 33 times since the 2025 season — most in NFL.

The 49ers are undefeated (4-0) after a loss since the 2025 season — T-best in NFL; League Avg: .424.

The 49ers are undefeated (10-0) when rushing for more than 100 yards since the 2025 season — best in NFL; League Avg: .615.

The 49ers are 11-1 (.917) when allowing less than 7 explosive plays since the 2025 season — best in NFL; League Avg: .581.

Seattle Seahawks: Keys to the Game vs. the San Francisco 49ers

The Seahawks are undefeated (4-0) vs top 10 defenses since the 2025 season They play the Patriots in Week 4 (Ranks fifth in total defense).

The Seahawks are 9-1 (.900) when not throwing an interception since the 2025 season — 6th-best in NFL. The 49ers have intercepted 7 passes since the 2025 season — 3rd-fewest in NFL.

The Seahawks are undefeated (5-0) vs top 10 pass defenses since the 2025 season They play the Patriots in Week 4 (Ranks ninth in passing defense).

The Seahawks are 12-4 (.750) when allowing less than 3 sacks since the 2025 season — 7th-best in NFL. The 49ers have averaged just 1.2 sacks per game over that time span — worst in NFL.

Additional Matchup Notes for San Francisco 49ers vs. Seattle Seahawks

The Seahawks have been successful on 38.5% of pass attempts when their QB was under pressure this season — 5th-best in NFL. The 49ers have pressured opposing QBs on just 17.2% of passing plays this season — 3rd-worst in NFL.

The Seahawks have scored on 14.3% of their drives in the first quarter this season — T-5th-worst in NFL. The 49ers defense has allowed scores on 11.1% of opponent drives in the first quarter this season — 3rd-best in NFL.

Seahawks QBs have been 33 sacked times since the 2025 season — 5th-fewest in NFL. The 49ers have sacked the quarterback 26 times since the 2025 season — fewest in NFL.

49ers RBs have averaged just 1.5 yards after contact per carry since the 2025 season — 2nd-worst in NFL. The Seahawks have allowed just 1.5 yards after contact per carry to RBs since the 2025 season — T-2nd-best in NFL.

49ers RBs have averaged 9.5 targets per game since the 2025 season — highest in NFL. The Seahawks have allowed 5.6 receptions per game to RBs since the 2025 season — 2nd-highest in NFL.

The 49ers are 10-1 (.909) when forcing 1 or more turnovers since the 2025 season — best in NFL. The Seahawks have turned the ball over 33 times since the 2025 season — most in NFL.

San Francisco 49ers Offense: Important Stats

The 49ers have run successful plays on 66% of pass attempts in the 3rd quarter since the 2025 season — best in NFL; League Avg: 48%.

The 49ers have a third down conversion rate of 57% this season — best in NFL; League Avg: 39%.

The 49ers have allowed a QB Hit on 10% of pass attempts this season — best in NFL; League Avg: 18%.

The 49ers have converted first downs on 8 of 18 plays (44%) on plays when their QB has been pressured this season — best in NFL; League Avg: 17%.

Seattle Seahawks Offense: Important Stats

The Seahawks have averaged 10.8 yards per play on play action passes since the 2025 season — best in NFL; League Avg: 7.3.

The Seahawks have averaged 11.4 yards per play on first drive of the game this season — best in NFL; League Avg: 5.4.

The Seahawks started 4 drives inside opposing territory in Week 4 — most in NFL.

The Seahawks have run 11% of their plays in their opponent’s territory in the 1st quarter this season — worst in NFL; League Avg: 41%.

San Francisco 49ers Defense: Important Stats

The 49ers defense has allowed rushes of 10+ yards on just 3 of 106 carries (3%) this season — best in NFL; League Avg: 10%.

The 49ers defense has averaged a sack every 29.0 pass attempts (755 Pass Attempts/26 Sacks) since the 2025 season — worst attempts per sack rate in NFL; League Avg: 14.8.

The 49ers defense have allowed 14.9 yards per play with a light rush since the 2025 season — worst in NFL; League Avg: 6.7.

The 49ers defense has sacked opposing QBs on just 3% of pass attempts (26/755) since the 2025 season — worst in NFL; League Avg: 7%.

Seattle Seahawks Defense: Important Stats

The Seahawks defense has allowed successful plays on 7% of rush attempts in the 3rd quarter this season — best in NFL; League Avg: 43%.

The Seahawks defense have allowed just 4.7 yards per play first read passes this season — best in NFL; League Avg: 8.4.

The Seahawks defense have allowed just 6.0 yards per play first read passes since the 2025 season — best in NFL; League Avg: 8.0.

The Seahawks defense has allowed 5.5 yards from scrimmage per touch (1,053 yards / 190 touches) this season — best in NFL; League Avg: 7.2.

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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