Broncos vs 49ers Prediction, Odds & Best Prop Bets – NFL, Week 4

• The 49ers are -3 point favorites vs the Broncos
• Total (Over/Under): 45.5 points
• Watch this game on CBS

The Denver Broncos (2-1-0) visit Levi’s Stadium to take on the San Francisco 49ers (3-0-0) on Oct. 4. Kickoff is scheduled for 4:25 pm in Santa Clara, CA.

The 49ers are betting favorites in this matchup, with the spread sitting at -3 (-102).

The Broncos vs. 49ers Over/Under is 45.5 total points for the game.

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Broncos vs. 49ers Odds, Spread, Over/Under

Broncos vs. 49ers Prediction

The winning team model predicts the 49ers will win this game with 59.0% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Broncos vs 49ers Spread Prediction

Based on recent against-the-spread trends, the model predicts the Broncos will cover the spread with 52.5% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Broncos players this game, looking at profitable historical betting trends:

Best Broncos Player Prop Bets Today

• RJ Harvey has hit the Longest Rush Under in 14 of his last 17 games (+10.55 Units / 55% ROI)
• RJ Harvey has hit the Receptions Over in his last 7 away games (+7.35 Units / 86% ROI)
• RJ Harvey has hit the Receiving Yards Over in his last 7 away games (+7.00 Units / 86% ROI)
• RJ Harvey has hit the Carries Under in 12 of his last 17 games (+6.55 Units / 33% ROI)
• Pat Bryant has hit the Receiving Yards Over in 10 of his last 13 games (+6.50 Units / 43% ROI)

And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:

Best 49ers Player Prop Best Bets Today

• Deebo Samuel has hit the Receptions Under in 11 of his last 15 games (+6.75 Units / 39% ROI)
• Brock Purdy has hit the Rushing Yards Over in his last 6 games at home (+6.00 Units / 87% ROI)
• Brock Purdy has hit the Longest Rush Over in his last 6 games at home (+6.00 Units / 85% ROI)
• Kyle Juszczyk has hit the Receptions Over in 8 of his last 13 games (+5.65 Units / 37% ROI)
• Kyle Juszczyk has hit the Longest Reception Over in 9 of his last 13 games (+4.20 Units / 28% ROI)

Anytime Touchdown Scorer Bet for 49ers vs Broncos

Broncos Best Bets:

• The Denver Broncos have hit the Moneyline in 17 of their last 21 games (+12.40 Units / 20% ROI)
• The Denver Broncos have hit the 1H Team Total Under in 13 of their last 19 games (+6.80 Units / 32% ROI)
• The Denver Broncos have covered the 4Q Spread in 12 of their last 18 games (+4.90 Units / 23% ROI)
• The Denver Broncos have hit the 4Q Moneyline in 11 of their last 18 games (+4.49 Units / 15% ROI)
• The Denver Broncos have covered the 1Q Spread in 5 of their last 7 away games (+2.15 Units / 23% ROI)

49ers Best Bets:

• The San Francisco 49ers have hit the Moneyline in 15 of their last 21 games (+13.85 Units / 30% ROI)
• The San Francisco 49ers have hit the 3Q Game Total Over in 14 of their last 18 games (+8.85 Units / 39% ROI)
• The San Francisco 49ers have covered the Spread in 14 of their last 21 games (+7.50 Units / 33% ROI)
• The San Francisco 49ers have hit the Team Total Over in 14 of their last 20 games (+7.05 Units / 31% ROI)
• The San Francisco 49ers have hit the 1H Moneyline in 13 of their last 21 games (+6.60 Units / 18% ROI)

Broncos Against the Spread (ATS) Record

Against the spread this NFL season, the Broncos are 2-1 (+0.9 Units / 26.87% ROI).

• Broncos are 2-1 when betting on the Moneyline for +1 Units / 28.57% ROI
• Broncos are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
• BroncosBroncosBroncos are 2-1 when betting the Under for +0.9 Units / 27.27% ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 2-1 (+0.9 Units / 27.27% ROI).

• 49ers are 3-0 when betting on the Moneyline for +3.7 Units / 26.06% ROI
• 49ers are 2-1 when betting the Over for +0.9 Units / 27.27% ROI
• 49ers are 1-2 when betting the Under for -1.2 Units / -36.36% ROI

Denver Broncos: Keys to the Game vs. the San Francisco 49ers

The Broncos are 14-3 (.824) when allowing less than 3 sacks since the 2025 season — T-5th-best in NFL. The 49ers have averaged just 1.3 sacks per game over that time span — worst in NFL.

The Broncos are 7-1 (.875) when not throwing an interception since the 2025 season — 7th-best in NFL. The 49ers have intercepted 7 passes since the 2025 season — 3rd-fewest in NFL.

The Broncos are 6-2 (.750) when not forcing a turnover since the 2025 season — best in NFL; League Avg: .267.

The Broncos are 16-4 (.800) since the 2025 season — T-best in NFL; League Avg: .498.

San Francisco 49ers: Keys to the Game vs. the Denver Broncos

The 49ers are 10-1 (.909) when allowing less than 7 explosive plays since the 2025 season — best in NFL; League Avg: .577.

The 49ers are undefeated (4-0) after a loss since the 2025 season — T-best in NFL; League Avg: .427.

The 49ers are 7-2 (.778) on the road since the 2025 season — 3rd-best in NFL; League Avg: .453.

The 49ers are 6-1 (.857) when within 7 points at the two minute warning since the 2025 season — best in NFL; League Avg: .497.

Additional Matchup Notes for Denver Broncos vs. San Francisco 49ers

The 49ers have scored on 53.8% of their drives in the first half this season — 4th-best in NFL. The Broncos defense has allowed scores on 50% of opponent drives in the first half this season — T-2nd-worst in NFL.

49ers RBs have averaged 9.6 targets per game since the 2025 season — highest in NFL. The Broncos have allowed just 3.2 receptions per game to RBs since the 2025 season — T-lowest in NFL.

49ers WRs have gained 15.8 Yards Per Reception this season — 4th-best in NFL. The Broncos have allowed 16.0 Yards Per Reception to WRs this season — 4th-worst in NFL.

Broncos QBs have been 28 sacked times since the 2025 season — T-2nd-fewest in NFL. The 49ers have sacked the quarterback 26 times since the 2025 season — fewest in NFL.

The Broncos are 14-3 (.824) when allowing less than 3 sacks since the 2025 season — T-5th-best in NFL. The 49ers have averaged just 1.3 sacks per game over that time span — worst in NFL.

The Broncos are 7-1 (.875) when not throwing an interception since the 2025 season — 7th-best in NFL. The 49ers have intercepted 7 passes since the 2025 season — 3rd-fewest in NFL.

Denver Broncos Offense: Important Stats

The Broncos have run 26% of their plays in their opponent’s territory in the 1st half this season — worst in NFL; League Avg: 45%.

The Broncos have averaged just 1.2 yards per play on first drive of the game this season — 2nd-worst in NFL; League Avg: 5.3.

The Broncos have run successful plays on 39% of plays on first read passes this season — worst in NFL; League Avg: 54%.

The Broncos have scored on 13% of their drives (2/15) in the 1st half this season — worst in NFL; League Avg: 38%.

San Francisco 49ers Offense: Important Stats

The 49ers have run successful plays on 84% of pass attempts in the 3rd quarter this season — best in NFL; League Avg: 44%.

The 49ers have converted first downs on 5 of 8 plays (62%) on 3rd and long this season — 2nd-best in NFL; League Avg: 27%.

The 49ers have run successful plays on 72% of plays on first read passes this season — 2nd-best in NFL; League Avg: 54%.

The 49ers have allowed a QB Hit on 8% of pass attempts this season — best in NFL; League Avg: 18%.

Denver Broncos Defense: Important Stats

The Broncos defense have missed 37 tackles this season — most in NFL.

The Broncos defense has allowed successful plays on 33% of pass attempts in the 4th quarter since the 2025 season — 2nd-best in NFL; League Avg: 45%.

The Broncos defense has averaged 3.8 sacks per game since the 2025 season — best in NFL; League Avg: 2.3.

The Broncos defense has allowed successful plays on 39% of plays against play action passes since the 2025 season — best in NFL; League Avg: 49%.

San Francisco 49ers Defense: Important Stats

The 49ers defense have allowed 14.9 yards per play with a light rush since the 2025 season — worst in NFL; League Avg: 6.7.

The 49ers defense has sacked opposing QBs on just 4% of pass attempts (26/713) since the 2025 season — worst in NFL; League Avg: 7%.

The 49ers defense has allowed rushes of 10+ yards on just 3 of 84 carries (4%) this season — best in NFL; League Avg: 11%.

The 49ers defense has allowed successful plays on 33% of pass attempts on motion plays this season — 2nd-best in NFL; League Avg: 47%.

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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