The Rams (5-4) visit the Cardinals (3-6) in Week 10 on Nov. 15, 2026, at State Farm Stadium in Glendale. Kickoff is set for 4:05 p.m. ET (1:05 p.m. PT), with the game airing on CBS and streaming on Paramount+.
Below, bettors can find NFL odds and a Cardinals vs Rams prediction for this NFC West matchup.
Cardinals vs Rams Odds: Spread, Moneyline & Total
Rams vs Cardinals Prediction
If Trent McDuffie and Kam Curl return to feature on the Rams defense in time for Sunday’s game, my Cardinals vs Rams prediction is the Cardinals Under 17.5 Points.
Gardner Minshew will start for a third straight game. However, he’ll have to contend with an improving pass rush and strong secondary, assuming the aforementioned players return.
Arizona moved the ball rather efficiently when they traveled to face the Rams. The offense recorded a 5.2% pass offense DVOA rating while reaching 18 points.
Mike LaFleur’s offense could have scored more if not for poor red zone efficiency. The Cardinals finished 0-for-5 in the red zone against a defense missing some key pieces.
McDuffie missed the contest for Los Angeles, in part explaining Arizona’s pass efficiency. Additionally, the Rams had yet to return Myles Garrett from injured reserve.
Garrett’s return to action in Washington clearly improved the Rams defense. Just in terms of pressure, LA’s pressure rate jumped from a 4% yearlong average to a 17% rate.
Now, the Rams get a Cardinals offense missing their best offensive lineman. Left tackle Paris Johnson Jr. is out for the season against a strong Rams front seven.
Los Angeles has consistently demonstrated an ability to stop the run. The Rams rank third in rush defense DVOA and posted a -31% average from Week 2-8.
After Week 9’s game against Washington, LA’s run defense rating improved from -26.1% to -26.9%.
Arizona has consistently failed to run the ball since losing Jeremiyah Love. Their lone “success” came at Dallas with a 22.9% rush DVOA grade.
But the Rams’ run defense does not equal the Cowboys’ run defense. If the Rams see improved health in the secondary, I predict the defense keeps Arizona under this benchmark.
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