Here’s a look at the current 2027 opponents for the San Francisco 49ers:
49ers Home Opponents
- Seattle Seahawks
- Arizona Cardinals
- Los Angeles Rams
- Minnesota Vikings
- Green Bay Packers
- Pittsburgh Steelers
- Cleveland Browns
- TBD – NFC South
49ers Away Opponents
- Seattle Seahawks
- Arizona Cardinals
- Los Angeles Rams
- Detroit Lions
- Chicago Bears
- Cincinnati Bengals
- Baltimore Ravens
- TBD – NFC East, AFC South
As customary, six of the 49ers’ 17 games will come against NFC West teams, one apiece at home and on the road.
The NFC West’s intraconference rotation features the AFC North. The 49ers will play the Steelers and Browns at home, and Bengals and Ravens on the road.
The NFC West’s interconference rotation features the NFC North. The 49ers will play the Vikings and Packers at home, and the Lions and Bears on the road.
The remaining games will be determined by their divisional finish after the 2026 season. Because it’s the NFC’s turn for nine away games — each NFC team has nine away games in odd-numbered seasons.
When is the 49ers Schedule Released?
The 49ers’ regular-season schedule will be released in May. While the NFL hasn’t announced a date for the full schedule release, recent years suggest it’ll be on a Wednesday or Thursday in the second or third week of the month.
Here are past dates of the NFL schedule release:
- 2026: Thursday, May 14
- 2025: Wednesday, May 14
- 2024: Wednesday, May 15
- 2023: Thursday, May 11
- 2022: Thursday, May 12
- 2021: Wednesday, May 12
- 2020: Thursday, May 7
49ers Week 1 Opponent
The 49ers’ Week 1 opponent hasn’t been determined yet. They opened the 2026 season with a game against the Los Angeles Rams (Australia).
Will the 49ers Play an International Game in 2026?
The 49ers could play an international game during the 2027 season. Through the 2026 season, the 49ers will have played five international games, most recently against the Minnesota Vikings in Mexico.
The NFL could play up to 11 international games in 2027.
You can bet on 49ers odds for each game at the online sportsbook.
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