This week’s list of the biggest college football spreads has a little something for everyone.Â
There are four likely College Football Playoff teams featured among the six biggest favorites of the week. That includes Boise State, who has become a significant favorite in my G6 Playoff Tracker.
And the biggest favorite on the board? That’s Indiana, which hasn’t covered a spread yet this season.
SMU -20.5 vs. Boston College
Boise State -20.5 vs. Utah State
Notre Dame -21 vs. North Carolina
New Mexico -22.5 vs. UTEP
Georgia -24 vs. Vanderbilt
Indiana -24 vs. Rutgers
Biggest Favorites For College Football Week 5 (2026)
- Indiana -24
- Georgia -24
- New Mexico -22.5
- Notre Dame -21
- Boise State -20.5
- SMU -20.5
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