College Football Top 25 Games: Thoughts and Odds for Every Week 10 Game

Alabama defensive back Red Morgan (16) hits LSU wide receiver Aaron Anderson (1) during the second half of an NCAA college football game, Saturday, Nov. 8, 2025, in Tuscaloosa, Ala.
(AP Photo/Vasha Hunt)

There will be no Saturday this college football season bigger than Week 10. 

After two months of conference games and playoff posturing, the stars have aligned this weekend to deliver tons of huge games with postseason implications.

Here are thoughts and college football odds for all 16 games featuring a ranked team in Week 10:

No. 22 Arizona vs. TCU

Sonny Dykes could be in danger of being the latest college football coach fired this year if this Friday night game gets out of hand. 

No. 15 Texas Tech vs. West Virginia

West Virginia is a deeply flawed team, but if you think laying 17.5 against the WVU offense is a good idea, I don’t know what to tell you. If this game is a pure West Texas shootout, West Virginia might win outright!

No. 3 Utah vs. No. 9 BYU

In this rivalry game with major Big 12 title implications, Utah appears to have the upper hand with an efficient rushing attack.

No. 18 Missouri vs. No. 7 Texas

We’re still doing this with Texas, huh? Laying points on the road with Arch Manning against a Top 25 team?

Minnesota vs. No. 8 UCLA

One week after nearly beating Indiana, can PJ Fleck’s gang beat one of the last undefeated college football teams?

No. 21 South Carolina vs. Texas A&M

South Carolina fans wanted to fire their coach about a month ago. This week, the Gamecocks are in the College Football Playoff Top 25 and laying a full touchdown against Texas A&M.

No. 14 LSU vs. No. 5 Alabama

LSU has looked like a playoff team since the loss at Kentucky, but Alabama will be the biggest test of that newfound form.

No. 12 Ohio State vs. No. 23 Oregon

There’s plenty of evidence after last week that Ohio State has existential problems on offense now, but the Buckeyes are still laying north of a touchdown against Oregon. 

No. 16 Wake Forest vs. Merrimack

The Deacs can name their score here. With ACC teams facing perception problems, I’ll guess that Wake doesn’t slow the offense down until they’ve cracked 55 points. 

No. 17 Houston vs. Cincinnati 

The Bearcats draw a third straight Top 25 team. Can they score another big upset?

Colorado State vs. No. 25 Boise State

It’s hard to see Boise tripping up on its playoff path against a team with a defense this bad.

No. 13 Tennessee vs. No. 6 Kentucky

Tennessee is nearly a full touchdown favorite against the SEC’s first-place team. But since the market has been loath to buy into Kentucky all season, there could be some value on the Wildcats here. 

No. 11 Notre Dame vs. No. 1 Miami

The history of No. 1 teams playing as underdogs is almost nonexistent! I have no clue what the right move is here, but I suppose I lean toward Notre Dame, since the Irish are simply more desperate. 

No. 10 Ole Miss vs. No. 2 Georgia

Ole Miss is a short home dog, but the Rebels will have a real chance to drag Georgia down into the ranks of the two-loss SEC teams. 

Northwestern vs. No. 19 Iowa

There has been a nonstop carousel this season of unranked, second-tier Big Ten teams beating ranked, second-tier Big Ten teams. The ranked loser drops out, the unranked winner pops into the bottom of the Top 25, and then the process repeats again the next week.

This Saturday night, it’ll be unranked Northwestern – fresh off a loss to Oregon – playing as a favorite against No. 19 Iowa. And, yes, the Hawkeyes just smoked ranked Wisconsin as an unranked team last weekend!

No. 24 Florida vs. Oklahoma

With Oklahoma’s offensive struggles this year, I’m honestly a little shocked that the Gators are available to bet for under a touchdown.

The content provided in this blog is intended for entertainment purposes only. All views and opinions expressed are the authors and reflect their individual perspectives on sports, betting, and related topics. This content should not be considered professional betting advice or the official views of BetMGM LLC. Please gamble responsibly. If you or someone you know is experiencing issues related to gambling, seek help from a licensed health professional. This blog is not liable for any losses, damages, or consequences resulting from betting activities.

About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.