Mississippi State vs. Missouri: Odds for Week 4 NCAA Football Betting

Mississippi State tight end Sam West (87) hushes the opposing fans after a 7-yard touchdown reception during the second half of an NCAA college football game against South Carolina Saturday, Sept. 19, 2026, in Columbia, S.C.
(AP Photo/Artie Walker Jr.)
Odds Boost This Weekend

Mississippi State is 3-0 and looking to earn respect in college football. So far, the Bulldogs have been overshadowed by archrival Ole Miss.

That oversight likely ends this week, as MSU is now ranked in the AP Top 25 and hosting a ranked opponent in Starkville.

BetMGM has NCAA football odds available for all the Week 4 college football action. 

Mississippi State vs. Missouri Odds

  • Point Spread: Mississippi State -6
  • Moneyline: Mississippi State -220  |  Missouri +180
  • Total: 58.5

Mississippi State vs. Missouri: Preview & Notes

Missouri hasn’t won or covered its SEC home opener in any of the last three seasons, but the Bulldogs are looking pretty feisty right now. MSU is set to host back-to-back ranked opponents before its Week 6 bye, with Alabama coming to Starkville next week.

All four all-time meetings between Missouri and Mississippi State have gone over the posted total, averaging about 65 points per game. 

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About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.