• The Red Sox are -155 favorites vs the Padres
• Padres vs Red Sox Over / Under today: 9 Runs
• Padres / Red Sox TV Channel: NESN | PDTV | ESUN

The San Diego Padres (+130) visit Fenway Park to take on the Boston Red Sox (-155) on April 5, 2026. First pitch is scheduled for 1:35 pm in Boston, MA.

This season, the Padres are 3-5 against the spread (ATS), while the Red Sox are 2-6 ATS.

Padres vs Red Sox Starting Pitchers Today:

• Padres starting pitcher: Walker Buehler 0-1, 6.76 ERA
• Red Sox starting pitcher: Ranger Suarez 0-1, 8.31 ERA

Padres vs. Red Sox Odds, Run Line, Over/Under & Moneyline

Padres vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Sunday‘s MLB game with 59.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Padres vs Red Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Padres players for Sunday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

• Manny Machado has hit the RBIs Under in 20 of his last 25 away games (+11.25 Units / 25% ROI)
• Xander Bogaerts has hit the Runs Under in his last 10 games (+10.00 Units / 51% ROI)
• Manny Machado has hit the Hits Under in 15 of his last 25 away games (+9.95 Units / 29% ROI)
• Jake Cronenworth has hit the Walks Under in 13 of his last 15 away games (+9.65 Units / 31% ROI)
• Manny Machado has hit the Hits Runs and RBIs Under in 17 of his last 25 away games (+9.10 Units / 33% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

• Caleb Durbin has hit the Hits Under in 12 of his last 20 games (+8.45 Units / 42% ROI)
• Caleb Durbin has hit the Hits Runs and RBIs Under in 15 of his last 20 games (+8.10 Units / 29% ROI)
• Wilyer Abreu has hit the Home Runs Over in 3 of his last 7 games (+7.90 Units / 113% ROI)
• Roman Anthony has hit the Singles Over in 8 of his last 9 games at home (+7.85 Units / 86% ROI)
• Caleb Durbin has hit the Runs Under in his last 7 games (+7.00 Units / 49% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Game Total Under in 86 of their last 151 games (+17.30 Units / 10% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 41 of their last 64 away games (+15.75 Units / 21% ROI)
• The San Diego Padres have hit the Team Total Under in 49 of their last 80 away games (+13.25 Units / 14% ROI)
• The San Diego Padres have covered the Run Line in 41 of their last 73 games (+7.00 Units / 7% ROI)
• The San Diego Padres have hit the Moneyline in 8 of their last 11 games (+4.65 Units / 32% ROI)

Red Sox Best Bets Today:

• The Boston Red Sox have hit the Moneyline in 60 of their last 100 games (+16.45 Units / 12% ROI)
• The Boston Red Sox have hit the Team Total Under in 48 of their last 78 games at home (+13.55 Units / 15% ROI)
• The Boston Red Sox have hit the Game Total Under in 45 of their last 78 games at home (+10.70 Units / 13% ROI)
• The Boston Red Sox have covered the Run Line in 45 of their last 80 games (+10.30 Units / 10% ROI)
• The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 29 of their last 47 games (+7.35 Units / 13% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 3-4 against the Run Line (-2.65 Units / -21.99% ROI).

• 3-5 when betting on the Moneyline for -2.25 Units / -24.73% ROI
• 2-5 when betting on the total runs Over for -3.45 Units / -38.98% ROI
• 5-2 when betting on the total runs Under for +2.9 Units / 33.14% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 2-6 against the Run Line (-4.15 Units / -46.89% ROI).

• 2-6 when betting on the Moneyline for -5.9 Units / -55.4% ROI
• 4-4 when betting on the total runs Over for -0.35 Units / -4% ROI
• 4-4 when betting on the total runs Under for -0.4 Units / -4.52% ROI

Padres Keys to the Game vs. the Red Sox

The Padres were 48-12 (.800) when they had 10 or more hits in the 2025 season — 5th best in MLB; League Avg: .743.

The Padres were 25-6 (.806) when they hit 2 or more home runs in the 2025 season — 5th best in MLB; League Avg: .699.

The Padres were 63-5 (.926) when leading entering the 7th inning in the 2025 season — 4th best in MLB; League Avg: .875.

The Padres were 32-17 (.653) vs bottom 10 scoring offenses in the 2025 season Today, they face the Red Sox (29th in runs scored).

Red Sox Keys to the Game vs. the Padres

The Red Sox were 37-14 (.725) when they scored in the first inning in the 2025 season — 4th best in MLB; League Avg: .636.

The Red Sox were 71-4 (.947) when leading entering the 8th inning in the 2025 season — tied for 2nd best in MLB; League Avg: .909.

The Red Sox were just 5-58 (.079) when trailing entering the 7th inning in the 2024 season — 3rd lowest in MLB; League Avg: .143.

The Red Sox were just 18-69 (.207) when they scored 4 or fewer runs in the 2024 season — 4th lowest in MLB; League Avg: .276.

Padres Hitting Stats & Trends

Padres hitters have an OPS of just .562 (192 PA’s) against RHP this season — 2nd lowest in MLB.

Padres hitters are slugging just .291 against RHP this season — 2nd lowest in MLB.

Padres hitters are slugging just .351 in non-two strike counts this season — lowest in MLB.

Padres hitters have struck out in just 18% of their PA’s against LHP since the 2024 season — best in MLB.

Red Sox Hitting Stats & Trends

The Red Sox batted .258 against LHP in the 2025 season — 4th best in MLB.

Red Sox hitters have drawn walks in 4% of their PA’s against LHP this season — 2nd lowest in MLB.

Red Sox hitters had 81 extra-base hits out of 186 total hits (43%) when facing the starting pitcher for the 3rd time in a game in the 2025 season — best in MLB.

Red Sox hitters have come to the plate with runners in scoring position in 1,801 of their 6,503 plate appearances (28%) since the 2025 season — highest in MLB.

Padres Pitching Stats & Trends

Padres pitchers had a strikeout rate of 24% in the 2025 season — tied for 4th best in MLB.

Padres pitchers had a strikeout rate of 45% with two-strikes in the 2025 season — 4th best in MLB.

The Padres pitchers allowed division opponents to score first in just 35% of their games in the 2025 season — tied for lowest in MLB.

Padres pitchers had an ERA of 3.16 (738.0 IP) at home in the 2025 season — 2nd best in MLB.

Red Sox Pitching Stats & Trends

Opponents have a groundball batting average of just .094 against Red Sox pitchers with runners on base this season — best in MLB.

Red Sox pitchers have walked 4% of batters when facing the leadoff batter in the inning this season — 3rd best in MLB.

Opponents have a groundball batting average of just .140 against Red Sox pitchers this season — 2nd best in MLB.

Opponents had a groundball rate of 46% against Red Sox pitchers in the 2025 season — 4th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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