• The Guardians are -130 favorites vs the Twins
• Twins vs Guardians Over / Under today: 8 Runs
• Twins / Guardians TV Channel: GDTV | TWTV

The Minnesota Twins (+105) visit Progressive Field to take on the Cleveland Guardians (-130) on July 22, 2026. First pitch is scheduled for 6:40 pm in Cleveland, OH.

This season, the Twins are 49-53 against the spread (ATS), while the Guardians are 50-51 ATS.

Twins vs Guardians Starting Pitchers Today:

• Twins starting pitcher: Bailey Ober 7-3, 4.33 ERA
• Guardians starting pitcher: Slade Cecconi 4-6, 4.58 ERA

Twins vs. Guardians Odds, Run Line, Over/Under & Moneyline

Twins vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Wednesday‘s MLB game with 54.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Twins vs Guardians and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Twins players for Wednesday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

• Josh Bell has hit the Total Bases Over in 18 of his last 25 away games (+15.80 Units / 54% ROI)
• Josh Bell has hit the Hits Over in 18 of his last 20 away games (+14.95 Units / 40% ROI)
• Josh Bell has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+10.30 Units / 37% ROI)
• Ryan Jeffers has hit the Home Runs Over in 3 of his last 8 games (+10.10 Units / 126% ROI)
• Josh Bell has hit the RBIs Under in his last 10 games (+10.00 Units / 46% ROI)

And here are some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Brayan Rocchio has hit the Home Runs Over in 3 of his last 10 games (+18.50 Units / 185% ROI)
• Chase DeLauter has hit the Hits Over in 22 of his last 25 games (+17.50 Units / 33% ROI)
• Chase DeLauter has hit the Walks Under in 21 of his last 25 games at home (+13.20 Units / 26% ROI)
• Chase DeLauter has hit the Singles Over in 19 of his last 25 games (+12.40 Units / 43% ROI)
• Brayan Rocchio has hit the Hits Runs and RBIs Over in 16 of his last 20 games (+12.30 Units / 56% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the Game Total Over in 30 of their last 45 away games (+15.65 Units / 32% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 30 away games (+11.80 Units / 32% ROI)
• The Minnesota Twins have hit the Team Total Over in 31 of their last 50 away games (+9.65 Units / 16% ROI)
• The Minnesota Twins have hit the Moneyline in 11 of their last 19 away games (+4.90 Units / 25% ROI)
• The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 18 of their last 30 games (+4.85 Units / 14% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 16 of their last 25 games (+7.30 Units / 25% ROI)
• The Cleveland Guardians have covered the Run Line in 8 of their last 10 games (+6.35 Units / 45% ROI)
• The Cleveland Guardians have hit the Moneyline in 7 of their last 9 games (+5.00 Units / 48% ROI)
• The Cleveland Guardians have hit the Game Total Under in 23 of their last 40 games (+4.15 Units / 9% ROI)
• The Cleveland Guardians have hit the Team Total Over in 8 of their last 12 games (+3.85 Units / 28% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 54-48 against the Run Line (-6.9 Units / -4.78% ROI).

• 49-53 when betting on the Moneyline for -2.05 Units / -1.83% ROI
• 56-40 when betting on the total runs Over for +11.65 Units / 10.35% ROI
• 40-56 when betting on the total runs Under for -21.65 Units / -19.35% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 50-51 against the Run Line (-3.55 Units / -2.68% ROI).

• 54-48 when betting on the Moneyline for +4.3 Units / 3.57% ROI
• 48-54 when betting on the total runs Over for -10.9 Units / -9.78% ROI
• 54-48 when betting on the total runs Under for +0.65 Units / 0.57% ROI

Guardians vs Twins Home Run Prop Bets Today

Guardians vs Twins Total Hits Prop Bets Today

Guardians vs Twins Strikeout Prop Bets Today

Twins Keys to the Game vs. the Guardians

The Twins are just 12-19 (.387) vs the bottom 10 runs allowed teams this season Today, they face the Guardians (eighth runs allowed).

The Twins are just 0-43 (.000) when trailing entering the 8th inning this season — lowest in MLB; League Avg: .097.

The Twins are just 0-46 (.000) when trailing entering the 9th inning this season — lowest in MLB; League Avg: .053.

The Twins are just 4-40 (.091) when trailing entering the 7th inning this season — 5th lowest in MLB; League Avg: .134.

Guardians Keys to the Game vs. the Twins

The Guardians are 21-16 (.568) vs the top 10 runs allowed teams this season Today, they face Twins (26th in runs allowed).

The Guardians are 11-1 (.917) when they’ve had 5 or more XBH this season — 4th best in MLB; League Avg: .786.

The Guardians are 28-20 (.583) after a loss this season — 5th best in MLB; League Avg: .486.

The Guardians are 39-3 (.929) when leading entering the 7th inning this season — 4th best in MLB; League Avg: .866.

Twins Hitting Stats & Trends

The Twins are batting just .288 on the first pitch of at-bats this season — lowest in MLB.

Twins hitters are slugging just .359 against LHP this season — 5th lowest in MLB.

Twins hitters have 59 extra-base hits out of 125 total hits (47%) on the first pitch of at-bats this season — best in MLB.

Twins hitters have an OPS of just .677 (1,141 PA’s) against LHP this season — 4th lowest in MLB.

Guardians Hitting Stats & Trends

The Guardians are batting just .196 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

The Guardians are batting just .218 on the road this season — lowest in MLB.

Guardians hitters have an OBP of just .265 (428 PA’s) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Guardians hitters have an OPS of just .660 (1,184 PA’s) against LHP this season — 3rd lowest in MLB.

Twins Pitching Stats & Trends

Twins pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 3rd highest in MLB.

Twins pitchers have an ERA of 5.33 (435.2 IP) on the road this season — 2nd highest in MLB.

Opponents have a groundball rate of just 39% against Twins pitchers this season — 3rd lowest in MLB.

Twins pitchers have a strikeout rate of just 20% in close and late situations this season — 4th lowest in MLB.

Guardians Pitching Stats & Trends

Opponents have a miss rate of 27% against Guardians pitchers this season — 4th best in MLB.

Guardians pitchers have a strikeout rate of 25% with runners in scoring position this season — tied for 2nd best in MLB.

Guardians pitchers have a strikeout rate of 24% this season — 4th best in MLB.

Guardians pitchers have allowed innings of 3+ runs in 4% of innings played this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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