Biggest Carolina Panthers Betting Upsets of Last 10 Years

Although the Panthers struggled during the 2023-24 season as underdogs, they’ve produced some big wins recently in that spot. 

Here are the 10 biggest Panthers upsets as underdogs over the last 10 seasons. 

Biggest Panthers Upsets of Last 10 Years

1. Panthers (+525) vs. Buccaneers, 2022-23

Both the biggest and most recent upset for the Panthers, who handed Tom Brady a 21-3 defeat. 

In another P.J. Walker start, the former XFL representative threw for 177 yards and two touchdowns to move the Panthers to 3-5 on the season. 

2. Panthers (+385) at Patriots, 2017-18

Stop me if you’ve heard this before – the Panthers relied on Newton in this 33-30 win. 

Newton threw for 316 yards and three touchdowns against the Patriots while adding 44 yards and a touchdown on the ground. 

3. Panthers (+350) at Saints, 2014-15

In the next outright win over the Saints, the Panthers produced a 41-10 win over the Saints. That qualified as only their fourth win of the season. 

The day belonged to Newton, who threw for 226 yards and three touchdowns. On the ground, he rushed for 83 yards and a touchdown. 

4. Panthers (+275) at Saints, 2018-19

This was another win that was never in doubt with the Panthers taking a 30-0 lead into the fourth quarter. 

Kyle Allen led the way for Carolina with 228 yards and two passing touchdowns, along with 19 rushing yards and a touchdown. 

5. Panthers (+270) at Seahawks, 2015-16

Newton passed for 269 yards against the Seahawks, 131 of which went to tight end Greg Olson.

That marked the Panthers’ fifth straight win to open the season in which they reached Super Bowl 50 against the Denver Broncos. 

6(t). Panthers (+260) at Redskins, 2016-17

The Panthers paid a visit to Kirk Cousins and the now-Commanders and pulled off a 26-15 road win as +261 underdogs. 

Carolina took a 23-9 advantage into the fourth quarter thanks to two touchdowns fromCam Newton, who passed for 300 yards on the day. 

6(t). Panthers (+260) at Cardinals, 2021-22

P.J. Walker relieved Cam Newton after only four passing attempts as the Panthers boat-raced the Cardinals 34-10. 

Prior to exiting, Newton passed for a touchdown and rushed for another while Chuba Hubbard also scored a touchdown for Carolina. 

8. Panthers (+230) at Chargers, 2019-20

The 0-2 Panthers paid a visit to the Los Angeles to face the 1-1 Chargers and raced out to an 18-7 halftime advantage. 

The Chargers did their best to make a comeback, but Carolina held on 21-16 for their sixth-largest moneyline upset over the last 10 years. 

9. Panthers (+225) at Texans, 2019-20

In another low-scoring contest, the Panthers used a 6-0 fourth quarter to win 16-10 over the Texans. 

Christian McCaffrey rushed for 93 yards and a touchdown against the Texans, who entered the game 2-1 on the season. 

10. Panthers (+210) vs. 49ers, 2013-14

Neither Cam Newton nor Colin Kaepernick passed for a touchdown as the Panthers earned a 10-9 home win. 

Panthers running back Deangelo Williams scored the only touchdown of the game as the Panthers earned a home win to move to 6-3 on the season.