Chargers vs Seahawks Prediction, Odds & Best Prop Bets – NFL, Week 4

• The Seahawks are -6.5 point favorites vs the Chargers
• Total (Over/Under): 45 points
• Watch this game on CBS

The Los Angeles Chargers (0-3-0) visit Lumen Field to take on the Seattle Seahawks (2-1-0) on Oct. 4. Kickoff is scheduled for 4:25 pm in Seattle, WA.

The Seahawks are betting favorites in this matchup, with the spread sitting at -6.5 (-135).

The Chargers vs. Seahawks Over/Under is 45 total points for the game.

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Chargers vs. Seahawks Odds, Spread, Over/Under

Chargers vs. Seahawks Prediction

The winning team model predicts the Seahawks will win this game with 65.4% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Chargers vs Seahawks Spread Prediction

Based on recent against-the-spread trends, the model predicts the Seahawks will cover the spread with 50.8% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Chargers players this game, looking at profitable historical betting trends:

Best Chargers Player Prop Bets Today

• Justin Herbert has hit the Interceptions Over in 12 of his last 16 games (+8.70 Units / 51% ROI)
• Justin Herbert has hit the Pass Attempts Under in 12 of his last 16 games (+7.15 Units / 38% ROI)
• Justin Herbert has hit the Completions Under in 12 of his last 16 games (+7.15 Units / 38% ROI)
• Tre Harris has hit the Receiving Yards Over in his last 7 away games (+7.00 Units / 86% ROI)
• Tre Harris has hit the Receptions Over in 10 of his last 14 games (+6.85 Units / 43% ROI)

And here are some top NFL player prop bets for Seahawks players for this matchup, looking at profitable historical betting trends:

Best Seahawks Player Prop Best Bets Today

• Jaxon Smith-Njigba has hit the Receptions Over in 14 of his last 18 games (+9.10 Units / 42% ROI)
• Emanuel Wilson has hit the Longest Rush Under in 11 of his last 14 games (+7.60 Units / 47% ROI)
• Elijah Arroyo has hit the Receptions Under in 8 of his last 9 games (+7.35 Units / 60% ROI)
• AJ Barner has hit the Longest Reception Under in 12 of his last 18 games (+5.10 Units / 25% ROI)
• Jaxon Smith-Njigba has hit the Receiving Yards Over in 12 of his last 18 games (+5.05 Units / 24% ROI)

First Touchdown Scorer Bet for Seahawks vs Chargers

Anytime Touchdown Scorer Bet for Seahawks vs Chargers

Chargers Best Bets:

• The Los Angeles Chargers have hit the 1H Team Total Under in 12 of their last 18 games (+7.10 Units / 35% ROI)
• The Los Angeles Chargers have hit the 3Q Game Total Under in 7 of their last 8 away games (+6.15 Units / 68% ROI)
• The Los Angeles Chargers have hit the 1Q Game Total Over in 7 of their last 8 away games (+5.75 Units / 60% ROI)
• The Los Angeles Chargers have covered the 3Q Spread in 10 of their last 17 games (+2.75 Units / 14% ROI)
• The Los Angeles Chargers have hit the 4Q Game Total Under in 10 of their last 17 games (+2.25 Units / 12% ROI)

Seahawks Best Bets:

• The Seattle Seahawks have hit the 2H Moneyline in 13 of their last 18 games (+6.80 Units / 18% ROI)
• The Seattle Seahawks have covered the 2H Spread in 12 of their last 18 games (+5.95 Units / 30% ROI)
• The Seattle Seahawks have hit the Moneyline in 15 of their last 21 games (+5.85 Units / 10% ROI)
• The Seattle Seahawks have covered the 4Q Spread in 12 of their last 18 games (+5.75 Units / 29% ROI)
• The Seattle Seahawks have hit the 1Q Moneyline in 11 of their last 21 games (+5.69 Units / 16% ROI)

Chargers Against the Spread (ATS) Record

Against the spread this NFL season, the Chargers are 0-3 (-3.3 Units / -100% ROI).

• Chargers are 0-3 when betting on the Moneyline for -8.7 Units / -100% ROI
• Chargers are 0-3 when betting the Over for -3.3 Units / -100% ROI
• ChargersChargersChargers are 3-0 when betting the Under for +3 Units / 90.91% ROI

Seahawks Against the Spread (ATS) Record

Against the spread this NFL season, the Seahawks are 1-1 (-0.1 Units / -2.99% ROI).

• Seahawks are 2-1 when betting on the Moneyline for -1.9 Units / -24.68% ROI
• Seahawks are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
• Seahawks are 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Los Angeles Chargers: Keys to the Game vs. the Seattle Seahawks

The Chargers are winless (0-4) when committing 60 or more yards in penalties since the 2025 season — worst in NFL; League Avg: .479.

The Chargers are 6-2 (.750) when within 7 points at the two minute warning since the 2025 season — 3rd-best in NFL; League Avg: .497.

The Chargers are winless (0-3) this season — T-worst in NFL; League Avg: .500.

The Chargers are 11-5 (.688) when committing less than 60 yards in penalties since the 2025 season — 9th-best in NFL; League Avg: .508.

Seattle Seahawks: Keys to the Game vs. the Los Angeles Chargers

The Seahawks are undefeated (3-0) vs top 10 defenses since the 2025 season They play the Patriots in Week 4 (Ranks fifth in total defense).

The Seahawks are undefeated (4-0) vs top 10 pass defenses since the 2025 season They play the Patriots in Week 4 (Ranks ninth in passing defense).

The Seahawks are 9-2 (.818) on the road since the 2025 season — best in NFL; League Avg: .453.

The Seahawks are 5-2 (.714) when rushing less than 25 times since the 2025 season — best in NFL; League Avg: .284.

Additional Matchup Notes for Los Angeles Chargers vs. Seattle Seahawks

No Matchup notes for this Game

The Chargers have run just 35.0% offensive plays on their opponent’s side of the field this season — worst in NFL. The Seahawks have allowed their opponents to run just 36.2% of plays in their territory this season — best in NFL.

The Chargers have been successful on just 42.3% of rush attempts on play action passes since the 2025 season — 5th-worst in NFL. The Seahawks have allowed a success rate of just 35.0% on rush attempts on play action passes since the 2025 season — 2nd-best in NFL.

The Chargers have scored on 22.2% of their drives in the second half this season — 4th-worst in NFL. The Seahawks defense has allowed scores on 18.8% of opponent drives in the second half this season — 3rd-best in NFL.

Los Angeles Chargers Offense: Important Stats

The Chargers have run successful plays on 24% of plays in the 4th quarter this season — worst in NFL; League Avg: 43%.

The Chargers have run 23% of their plays in their opponent’s territory in the 2nd half this season — worst in NFL; League Avg: 50%.

The Chargers have an average drive start position from the 21.2 yard line this season — worst in NFL; League Avg: 28.3.

The Chargers have averaged just 1.2 yards per play against tight coverage this season — worst in NFL; League Avg: 3.5.

Seattle Seahawks Offense: Important Stats

The Seahawks started 7 drives inside their own 20 yard line in Week 3 — most in NFL.

The Seahawks have averaged 10.8 yards per play on play action passes since the 2025 season — best in NFL; League Avg: 7.3.

The Seahawks have averaged 12.5 yards per play on first drive of the game this season — best in NFL; League Avg: 5.3.

The Seahawks have converted first downs on just 2 of 7 plays (29%) on 3rd and short this season — worst in NFL; League Avg: 60%.

Los Angeles Chargers Defense: Important Stats

The Chargers defense forced 5 turnovers in Week 3 — T-most in NFL.

The Chargers defense has allowed a late down conversion rate of 16% when opponents had 4-6 yards to go this season — worst in NFL; League Avg: 10%.

The Chargers defense has allowed a Completion Pct of just 41% (9 completions/22 attempts) on 3rd and short since the 2025 season — 2nd-best in NFL; League Avg: 60%.

The Chargers defense allowed 7 broken tackles in Week 3 — 2nd-most in NFL.

Seattle Seahawks Defense: Important Stats

The Seahawks defense have allowed just 6.3 yards per play open coverage this season — best in NFL; League Avg: 9.7.

The Seahawks defense have allowed just 6.0 yards per play first read passes since the 2025 season — best in NFL; League Avg: 8.0.

The Seahawks defense has allowed successful plays on 9% of rush attempts in the 3rd quarter this season — 2nd-best in NFL; League Avg: 45%.

The Seahawks defense has stuffed 50% (18/36) of rushing attempts on 3rd and short since the 2025 season — best in NFL; League Avg: 22%.

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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