Eagles vs. 49ers: NFL Wild Card Odds, Prediction

See the latest NFL Wild Card odds, picks and predictions for Eagles vs. 49ers on January 11 at Lincoln Financial Field.
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  • The Eagles are currently a 5-point home favorite against the 49ers.
  • Jalen Hurts is 19-1 SU at home against teams with a winning record.
  • My Eagles vs 49ers prediction is for the Eagles (-3.5) to cover the spread.

It’s a rematch of the 2022 NFC Championship game as the Eagles host the 49ers. 

Philadelphia won the NFC East thanks to a strong first half of the year. The Eagles started 8-2 and, after a three-game skid, won three of their final four games. 

San Francisco won six of its final seven games, but fell 13-3 in Week 18 against the Seahawks. That loss, along with a Rams win, resigned the Niners to the six seed in the NFC. 

Bet on Eagles vs. 49ers and other NFL matchups with up-to-date NFL odds. 

Eagles vs. 49ers: NFL Wild Card Odds

Eagles vs. 49ers Prediction

Based on the glaring mismatch between the Niners offense and Eagles defense, my Eagles vs 49ers prediction is the Philadelphia Eagles Spread (-3.5, -105). 

It’s a limited sample, but Brock Purdy is 0-4 ATS in his career as a market underdog. Now, the potent Niners offense gets arguably the best defense left in the postseason. 

From Week 10-17, Vic Fangio’s unit ranked fourth in EPA per play and third in defensive success rate. That even coincided with Jalen Carter missing a few games! 

Even more impressive about Philly is that the unit, for the first 17 weeks, ranked sixth in defensive DVOA, having played the second-hardest set of opposing offenses. 

The Niners ranked second in offensive DVOA over the same sample, having faced the third-hardest set of defenses. 

However, the team struggled against good units. Seattle limited San Francisco to three points in Week 18 after allowing 17 in Week 1. 

San Francisco managed 26 at Cleveland, but defensive turnovers aided their effort. Philadelphia takes better care of the ball, so it’ll force longer drives for Purdy & company. 

While I maintain concerns about Philly’s offense, a banged-up Niners defense offers a decent get-right spot. Given those factors, I predict the Eagles cover at home. 

Betting Eagles vs. 49ers: NFL Public Betting

Team% of ATS Bets% of ATS Money
49ers (+4.5)50%30%
Eagles (-4.5)50%70%

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About the Author Read More @nickhennion

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.