Rams vs Cardinals Prediction, Odds & Best Prop Bets – NFL, Week 10

• The Rams are -8.5 point favorites vs the Cardinals
• Total (Over/Under): 47.5 points
• Watch this game on CBS

The Los Angeles Rams (5-4-0) visit State Farm Stadium to take on the Arizona Cardinals (3-6-0) on Nov. 15. Kickoff is scheduled for 4:05 pm in Glendale, AZ.

The Rams are betting favorites in this matchup, with the spread sitting at -8.5 (-120).

The Rams vs. Cardinals Over/Under is 47.5 total points for the game.

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Rams vs. Cardinals Odds, Spread, Over/Under

Rams vs. Cardinals Prediction

The winning team model predicts the Rams will win this game with 82.0% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Rams vs Cardinals Spread Prediction

Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread with 50.5% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Rams players this game, looking at profitable historical betting trends:

Best Rams Player Prop Bets Today

• Puka Nacua has hit the Rushing Yards Under in 9 of his last 12 games (+5.30 Units / 36% ROI)
• Colby Parkinson has hit the Receptions Over in 11 of his last 17 games (+4.80 Units / 25% ROI)
• Davante Adams has hit the Receptions Under in 10 of his last 14 games (+4.75 Units / 26% ROI)
• Blake Corum has hit the Receiving Yards Under in 11 of his last 16 games (+4.60 Units / 22% ROI)
• Kyren Williams has hit the Receptions Over in 8 of his last 11 away games (+4.55 Units / 30% ROI)

And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today

• Tyler Allgeier has hit the Receptions Over in 11 of his last 15 games (+7.62 Units / 41% ROI)
• Trey McBride has hit the Receptions Over in 12 of his last 17 games (+7.20 Units / 37% ROI)
• Zonovan Knight has hit the Receptions Over in 7 of his last 8 games (+6.60 Units / 59% ROI)
• Jeremiyah Love has hit the Longest Reception Under in his last 6 games (+6.05 Units / 91% ROI)
• Zonovan Knight has hit the Receiving Yards Over in 7 of his last 8 games (+5.85 Units / 62% ROI)

Rams Best Bets:

• The Los Angeles Rams have hit the Team Total Over in 15 of their last 22 games (+6.75 Units / 26% ROI)
• The Los Angeles Rams have hit the 4Q Game Total Over in 8 of their last 11 away games (+4.70 Units / 37% ROI)
• The Los Angeles Rams have hit the 1Q Game Total Under in 12 of their last 21 games (+1.60 Units / 7% ROI)
• The Los Angeles Rams have hit the 4Q Moneyline in 8 of their last 20 games (+1.46 Units / 4% ROI)
• The Los Angeles Rams have hit the 1H Team Total Over in 12 of their last 21 games (+1.05 Units / 4% ROI)

Cardinals Best Bets:

• The Arizona Cardinals have hit the 2H Game Total Over in 12 of their last 17 games (+6.35 Units / 32% ROI)
• The Arizona Cardinals have covered the 4Q Spread in 12 of their last 17 games (+6.25 Units / 32% ROI)
• The Arizona Cardinals have hit the 3Q Game Total Over in 12 of their last 17 games (+6.25 Units / 31% ROI)
• The Arizona Cardinals have hit the Team Total Under in 7 of their last 8 games at home (+5.75 Units / 65% ROI)
• The Arizona Cardinals have hit the 1H Team Total Under in 12 of their last 18 games (+5.08 Units / 24% ROI)

Rams Against the Spread (ATS) Record

Against the spread this NFL season, the Rams are 5-4 (+0.6 Units / 6.09% ROI).

• Rams are 5-4 when betting on the Moneyline for -8.3 Units / -33.33% ROI
• Rams are 4-5 when betting the Over for -1.5 Units / -15.15% ROI
• RamsRamsRams are 5-4 when betting the Under for +0.6 Units / 6.06% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 4-5 (-1.5 Units / -15.15% ROI).

• Cardinals are 3-6 when betting on the Moneyline for +6.35 Units / 67.55% ROI
• Cardinals are 5-4 when betting the Over for +0.6 Units / 6.06% ROI
• Cardinals are 4-5 when betting the Under for -1.5 Units / -15.15% ROI

Los Angeles Rams: Keys to the Game vs. the Arizona Cardinals

Rams are 16-5 (.762) when allowing less than 5 yards per rush (T-4th-best in NFL) and just .200 when allowing more than 5 yards per rush since the 2025 season (T-6th-worst in NFL).

Rams are 16-6 (.727) when allowing less than 3 explosive run plays in a game (9th-best in NFL) and just .250 when allowing 3 or more explosive run plays in a game since the 2025 season (T-10th-worst in NFL).

The Rams are 15-6 (.714) when allowing less than 3 sacks since the 2025 season — 10th-best in NFL. The Cardinals have averaged just 1.9 sacks per game over that time span — T-5th-worst in NFL.

The Rams are 4-2 (.667) vs top 10 pass defenses since the 2025 season They play the Cardinals in Week 10 (Ranks 25th in passing defense).

Arizona Cardinals: Keys to the Game vs. the Los Angeles Rams

Cardinals are 3-19 (.136) when making less than 3 explosive run plays in a game (2nd-worst in NFL) and .750 when making 3 or more explosive run plays in a game since the 2025 season (T-10th-best in NFL).

The Cardinals are winless (0-3) at home this season — T-worst in NFL; League Avg: .508.

The Cardinals are winless (0-3) after a win this season — T-worst in NFL; League Avg: .505.

The Cardinals are 1-13 (.071) when allowing 7 or more explosive plays since the 2025 season — worst in NFL; League Avg: .402.

Additional Matchup Notes for Los Angeles Rams vs. Arizona Cardinals

The Cardinals have been successful on just 35.3% of rush attempts on play action passes since the 2025 season — 3rd-worst in NFL. The Rams have allowed a success rate of just 28.6% on rush attempts on play action passes since the 2025 season — best in NFL.

The Cardinals have been successful on just 34.6% of rush attempts since Week 6 — 5th-worst in NFL. The Rams have allowed a success rate of just 29.2% on rush attempts since Week 6 — 2nd-best in NFL.

The Cardinals scored on 11.1% of their drives last week — worst in NFL. The Rams defense allowed scores on 27.3% of opponent drives last week — 4th-best in NFL.

The Rams have a third down conversion rate of just 11.8% on 3rd and 10+ YTG since the 2025 season — worst in NFL. The Cardinals defense has allowed a third down conversion rate of just 12.2% on 3rd and 10+ YTG since the 2025 season — 3rd-best in NFL.

The Rams have 62 touchdown passes since the 2025 season — most in NFL. The Cardinals have allowed 50 passing TDs since the 2025 season — 3rd-most in NFL.

The Rams have been successful on 51.1% of pass attempts on their opponent’s side of the field since the 2025 season — 3rd-best in NFL. The Cardinals have allowed a success rate of 50.5% on pass attempts on their own side of the field since the 2025 season — 5th-worst in NFL.

Los Angeles Rams Offense: Important Stats

The Rams have run successful plays on 56% of plays in the 4th quarter this season — best in NFL; League Avg: 43%.

The Rams have run successful plays on 23% of rush attempts on play action passes since the 2025 season — worst in NFL; League Avg: 50%.

The Rams have run successful plays on 52% of rush attempts since the 2025 season — best in NFL; League Avg: 43%.

The Rams have thrown for 62 TDs since the 2025 season — most in NFL.

Arizona Cardinals Offense: Important Stats

The Cardinals have gone three and out 14 times in the 2nd quarter this season — most in NFL.

The Cardinals have turned the ball over on downs 12 times in the red zone since the 2025 season — most in NFL.

The Cardinals have turned the ball over on downs 5 times in the red zone this season — most in NFL.

The Cardinals have targeted TEs 33% of the time (337 Pass Attempts/1,008 plays) since the 2025 season — highest in NFL; League Avg: 23%.

Los Angeles Rams Defense: Important Stats

The Rams defense forced 4 fumbles in Week 9 — most in NFL.

The Rams defense has not allowed a successful play on any rush attempt first read passes since the 2025 season — T-best in NFL; League Avg: 37%.

The Rams defense has allowed 10 rushing TDs on 100 carries (10 Carries Per TD) in the red zone since the 2025 season — best Carries Per TD rate in NFL; League Avg: 5.6.

The Rams defense has allowed successful plays on 29% of rush attempts against play action passes since the 2025 season — best in NFL; League Avg: 50%.

Arizona Cardinals Defense: Important Stats

22% of the plays run against the Cardinals have been in the red zone in the 2nd half since the 2025 season — worst in NFL; League Avg: 15%.

The Cardinals defense has allowed 9 TDs that were 20+ yards this season — 2nd-most in NFL.

The Cardinals defense have allowed 8.7 yards per play on first drive of the game this season — worst in NFL; League Avg: 5.4.

The Cardinals defense has allowed a passer rating of just 0.0 when the opposing QB has scrambled (10 Pass Attempts) this season — T-best in NFL; League Avg: 59.5.

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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