49ers vs Cowboys Prediction, Odds & Best Prop Bets – NFL, Week 10

• The 49ers are -4.5 point favorites vs the Cowboys
• Total (Over/Under): 55.5 points
• Watch this game on FOX

The San Francisco 49ers (7-1-0) visit AT&T Stadium to take on the Dallas Cowboys (4-5-0) on Nov. 15. Kickoff is scheduled for 4:25 pm in Arlington, TX.

The 49ers are betting favorites in this matchup, with the spread sitting at -4.5 (-105).

The 49ers vs. Cowboys Over/Under is 55.5 total points for the game.

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49ers vs. Cowboys Odds, Spread, Over/Under

49ers vs. Cowboys Prediction

The winning team model predicts the 49ers will win this game with 54.7% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

49ers vs Cowboys Spread Prediction

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 50.6% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:

Best 49ers Player Prop Bets Today

• Christian McCaffrey has hit the Longest Reception Under in 13 of his last 17 games (+8.65 Units / 45% ROI)
• Brock Purdy has hit the Longest Rush Over in 12 of his last 17 games (+6.60 Units / 34% ROI)
• Brock Purdy has hit the Rushing Yards Over in 12 of his last 17 games (+6.10 Units / 31% ROI)
• Demarcus Robinson has hit the Receptions Over in 8 of his last 11 games (+5.55 Units / 41% ROI)
• Eddy Pineiro has hit the Field Goals Under in 10 of his last 15 games (+5.05 Units / 31% ROI)

And here are some top NFL player prop bets for Cowboys players for this matchup, looking at profitable historical betting trends:

Best Cowboys Player Prop Best Bets Today

• Jake Ferguson has hit the Receiving Yards Under in 12 of his last 16 games (+7.45 Units / 40% ROI)
• Jake Ferguson has hit the Receptions Under in 11 of his last 15 games (+6.40 Units / 35% ROI)
• KaVontae Turpin has hit the Receiving Yards Over in 8 of his last 10 games (+5.70 Units / 50% ROI)
• Jake Ferguson has hit the Longest Reception Under in 11 of his last 16 games (+5.38 Units / 29% ROI)
• Dak Prescott has hit the Passing Yards Over in 11 of his last 16 games (+5.25 Units / 29% ROI)

49ers Best Bets:

• The San Francisco 49ers have hit the Moneyline in 16 of their last 20 games (+14.20 Units / 27% ROI)
• The San Francisco 49ers have hit the 1H Moneyline in 14 of their last 20 games (+9.55 Units / 24% ROI)
• The San Francisco 49ers have covered the Spread in 14 of their last 20 games (+8.60 Units / 39% ROI)
• The San Francisco 49ers have covered the 1Q Spread in 13 of their last 18 games (+7.45 Units / 36% ROI)
• The San Francisco 49ers have hit the 1Q Moneyline in 12 of their last 20 games (+7.15 Units / 23% ROI)

Cowboys Best Bets:

• The Dallas Cowboys have hit the Game Total Over in 15 of their last 20 games (+9.50 Units / 43% ROI)
• The Dallas Cowboys have hit the 1Q Game Total Over in 13 of their last 18 games (+7.65 Units / 35% ROI)
• The Dallas Cowboys have hit the 1H Game Total Over in 7 of their last 9 games at home (+4.85 Units / 46% ROI)
• The Dallas Cowboys have hit the 2Q Game Total Under in 11 of their last 17 games (+4.35 Units / 23% ROI)
• The Dallas Cowboys have hit the 2H Game Total Over in 10 of their last 17 games (+2.11 Units / 11% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 5-3 (+1.7 Units / 19.32% ROI).

• 49ers are 7-1 when betting on the Moneyline for +6.65 Units / 25.09% ROI
• 49ers are 4-4 when betting the Over for -0.4 Units / -4.55% ROI
• 49ers49ers49ers are 4-4 when betting the Under for -0.4 Units / -4.55% ROI

Cowboys Against the Spread (ATS) Record

Against the spread this NFL season, the Cowboys are 5-4 (+0.6 Units / 6% ROI).

• Cowboys are 4-5 when betting on the Moneyline for -7.8 Units / -40.21% ROI
• Cowboys are 6-3 when betting the Over for +2.7 Units / 27.27% ROI
• Cowboys are 3-6 when betting the Under for -3.6 Units / -36.36% ROI

San Francisco 49ers: Keys to the Game vs. the Dallas Cowboys

The 49ers are 10-4 (.714) when passing for 250 or more yards since the 2025 season — T-6th-best in NFL. The Cowboys have allowed 242.4 passing yards per game since the 2025 season — worst in NFL.

The 49ers are 12-1 (.923) when rushing for 120 or more yards since the 2025 season — T-3rd-best in NFL. The Cowboys have allowed an average of 134.2 rushing yards per game since the 2025 season — 4th-worst in NFL.

The 49ers are 10-0 (1.000) when not throwing an interception since the 2025 season — T-best in NFL. The Cowboys have intercepted 10 passes since the 2025 season — 2nd-fewest in NFL.

The 49ers are 4-1 (.800) vs top 10 offenses since the 2025 season They play the Cowboys in Week 10 (Ranks first in total offense).

Dallas Cowboys: Keys to the Game vs. the San Francisco 49ers

Cowboys are 1-9-1 (.091) when allowing more than 50% of third down conversions opportunities (10th-worst in NFL) and .667 when allowing less than 50% of third down conversions opportunities since the 2025 season (T-9th-best in NFL).

The Cowboys are winless (0-4) when passing for less than 200 yards since the 2025 season — worst in NFL; League Avg: .439.

The Cowboys are 1-10 (.091) when converting less than 55% of its red zone chances into touchdowns since the 2025 season — 2nd-worst in NFL; League Avg: .404.

The Cowboys are winless (0-3) after a win this season — T-worst in NFL; League Avg: .505.

Additional Matchup Notes for San Francisco 49ers vs. Dallas Cowboys

The Cowboys have been successful on 46.2% of rush attempts since the 2025 season — 5th-best in NFL. The 49ers have allowed a success rate of 47.5% on rush attempts since the 2025 season — worst in NFL.

Cowboys RBs have averaged just 1.2 yards after contact per carry this season — T-2nd-worst in NFL. The 49ers have allowed just 1.3 yards after contact per carry to RBs this season — T-best in NFL.

Cowboys RBs have averaged just 6.5 yards after the catch since the 2025 season — 4th-worst in NFL. The 49ers have allowed just 7.1 yards after catch per reception to RBs since the 2025 season — T-5th-best in NFL.

The 49ers have been successful on 51.2% of plays they have run with motion this season — best in NFL. The Cowboys have allowed a success rate of 47.1% against motion this season — 4th-worst in NFL.

The 49ers have a third down conversion rate of 51.7% this season — 2nd-best in NFL. The Cowboys defense has allowed a third down conversion rate of 48.3% this season — worst in NFL.

The 49ers have run 52.8% offensive plays on their opponent’s side of the field this season — 3rd-best in NFL. The Cowboys have allowed their opponents to run 51.7% of plays in their territory this season — 5th-worst in NFL.

San Francisco 49ers Offense: Important Stats

The 49ers have a third down conversion rate of 52% this season — 2nd-best in NFL; League Avg: 39%.

The 49ers have converted first downs on 17 of 45 plays (38%) on plays when their QB has been pressured this season — best in NFL; League Avg: 17%.

The 49ers have converted first downs on 41 of 113 plays (36%) on 3rd and long since the 2025 season — best in NFL; League Avg: 24%.

The 49ers did not go three and out on any of their drives in Week 9 — T-best in NFL; League Avg: 20%.

Dallas Cowboys Offense: Important Stats

The Cowboys have scored on 58% of their drives (25/43) in the 2nd half this season — best in NFL; League Avg: 38%.

The Cowboys have gone three and out on 14% of their drives since the 2025 season — best in NFL; League Avg: 20%.

The Cowboys have thrown the ball 60% of the time (59 Pass Attempts/98 plays) on 3rd and short since the 2025 season — highest in NFL; League Avg: 42%.

The Cowboys have run the ball on 38% of plays (37 carries/98 plays) on 3rd and short since the 2025 season — lowest in NFL; League Avg: 55%.

San Francisco 49ers Defense: Important Stats

The 49ers defense tackled opponents for a loss on 5 of 15 rushing attempts (33% TFL%) in Week 9 — best in NFL; League Avg: 13%.

The 49ers defense has allowed rushes of 10+ yards on just 5 of 189 carries (3%) this season — best in NFL; League Avg: 10%.

The 49ers defense forced 5 turnovers in Week 9 — T-most in NFL.

The 49ers defense has allowed successful plays on 15% of rush attempts in the 4th quarter since Week 6 — best in NFL; League Avg: 43%.

Dallas Cowboys Defense: Important Stats

67% of the plays ran against the Cowboys were in the red zone in the 1st quarter in Week 9 — worst in NFL; League Avg: 19%.

The Cowboys defense has allowed 5 TDs on first drive of the game this season — T-most in NFL.

The Cowboys defense has allowed scores on 52% of opponent drives (32/62) in the 1st quarter since the 2025 season — worst in NFL; League Avg: 32%.

The Cowboys defense has allowed a passer rating of 84.0 when they have pressured the QB (197 Pass Attempts) since the 2025 season — worst in NFL; League Avg: 53.0.

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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