Biggest Favorites For College Football Week 10

Toledo cornerback Tyrell Russell plays during an NCAA college football game, Friday, Sept. 4, 2026, in East Lansing, Mich.
(AP Photo/Al Goldis)

The biggest college football spreads in Week 10 include almost no P4 conference games. 

West Virginia and Rutgers are the only teams on today’s list. And one of them might have some real value as a moneyline underdog!

The remaining teams featured in today’s list of the biggest college football favorites of the week are accomplished G6 teams playing against some of the worst teams in FBS. 

Texas Tech -16.5 vs. West Virginia

Jacksonville State -17 vs. Sam Houston

North Texas -17 vs. Rice

Liberty -17 vs. New Mexico State

Boise State -17.5 vs. Colorado State

Toledo -25.5 vs Sac State

Biggest Favorites For College Football Week 10

  • Toledo -25.5
  • Boise State -17.5
  • Liberty -17
  • North Texas -17
  • Wisconsin -17
  • Jacksonville State -17
  • Texas Tech -16.5

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About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.