By now, most college football teams have played at least two conference games, if not more.
But FBS college football is big enough that there are always non-conference games happening somewhere. And if you look at the biggest college football spreads on the board this week at BetMGM, many of those large favorites are teams stepping out of league play for a random, one-off, non-conference opponent.
How motivated will these big favorites be to keep putting points on the board in the second half? That’s hard to say.
Toledo -20 vs. Buffalo
Arizona State -20.5 vs Hawai’i
North Texas -27.5 vs. Charlotte
Ohio State -34.5 vs. Maryland
Northwestern -36 vs. Ball State
Notre Dame -37.5 vs. Stanford
Biggest Favorites For College Football Week 6 (2026)
- Notre Dame -37.5
- Northwestern -36
- Ohio State -34.5
- North Texas -27.5
- Arizona State -20.5
- Toledo -20
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