Clemson vs. LSU: Week 1 Odds for Power Showdown

LSU running back Caden Durham (29) plays during an NCAA college football game between Clemson and LSU Saturday, Aug. 30, 2025, in Clemson, S.C.
(AP Photo/Jacob Kupferman)
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Baton Rouge is once again a College GameDay location. The world of college football is checking in on Saturday for another battle of the Death Valleys.

BetMGM has NCAA football odds available for all the Week 1 college football action. 

Clemson vs LSU Odds

  • Point Spread: LSU -10.5
  • Moneyline: LSU -425 |  Clemson +320
  • Total: 51.5

Clemson vs LSU: Preview & Notes

Clemson still carries the perception of national relevance, but the Tigers are 1-5 ATS in their last six games against the SEC. They’re also 2-7 ATS in their last nine home openers against teams from power conferences.

Despite those trends, the line is moving away from LSU and toward Clemson early this week. 

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About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.