Michigan vs. Iowa: Odds for Week 4 NCAA Football Betting

Iowa head coach Kirk Ferentz reacts to a call during the first half of an NCAA college football game against Michigan State, Saturday, Nov. 22, 2025, in Iowa City, Iowa.
(AP Photo/Charlie Neibergall)
Sportsbook Promos This Week

Offense should be at a premium in Ann Arbor this week when Michigan opens conference play against Iowa. 

BetMGM has NCAA football odds available for all the Week 4 college football action. 

Michigan vs. Iowa Odds

  • Point Spread: Michigan -4.5
  • Moneyline: Michigan -190  |  Iowa +160
  • Total: 37.5

Michigan vs. Iowa: Preview & Notes

Iowa might have a long list of Big Ten victims, but Michigan isn’t generally one of them. The Hawkeyes are 0-4 straight up and against the number in their last four games against Michigan, including conference championship games in 2021 and 2023.

Iowa is also 1-4 outright and 1-3-1 against the spread in its last five trips to Ann Arbor. 

The under is 5-1 across the last six games.

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About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.