USC vs. San Jose State: Week 0 Odds

Southern California quarterback Jayden Maiava gestures to teammates during the first half of an NCAA college football game against Iowa, Saturday, Nov. 15, 2025, in Los Angeles.
(AP Photo/Mark J. Terrill)
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Jayden Maiava will begin his 2026 Heisman campaign with an excellent opportunity to pad his stats and show off to a national television (NBC) audience. 

The Trojans – a playoff dark horse this year – will begin the year against San Jose State, with G6 CFP contender Fresno State on deck next.

BetMGM has NCAA football odds available for all the Week 0 college football action. 

USC vs. San Jose State Odds

  • Point Spread: USC -38.5
  • Moneyline: N/A
  • Total: 60.5

USC vs. San Jose State: Preview & Notes

USC is 5-0 in season openers under Lincoln Riley, including a 4-1 ATS record. But in the two games the Trojans have played against San Jose State over the last five seasons, they haven’t accumulated a winning margin near 40. Southern Cal won 30-7 in 2021 and 56-28 in 2023.

In a Week 0 that often tends toward clunky play, a big dog cover looks quite possible. But betting against Maiava can be scary… assuming USC leaves him in for the whole game. 

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About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.