Seahawks vs. 49ers: NFL Divisional Round Odds, Prediction

See the latest NFL divisional Round odds, picks and predictions for Seahawks vs. 49ers on January 18 at Lumen Field.
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  • The Seahawks are predicted to be a seven-point home favorite against the 49ers.
  • San Francisco has lost three games in a row against the Seahawks.
  • My Seahawks vs 49ers prediction is the Total Under 46.5 Points (-110).

Seattle will go for a fourth straight win over the 49ers as heavy home favorites in the divisional round. 

San Francisco surprised the Eagles with a 24-19 win in the wild-card round. The win ended a four-game ATS failure streak by Brock Purdy despite a pair of interceptions. 

Now, the Niners take on the top-seeded Seahawks for the second time in three weeks. In the last meeting, Seattle won 13-3 as 2.5-point road favorites at Levi’s Stadium. 

Bet on Seahawks vs. 49ers and other NFL matchups with up-to-date NFL odds

Seahawks vs. 49ers: NFL Divisional Round Odds

Seahawks vs. 49ers Prediction

Based on San Francisco’s offensive struggles against the Seahawks and Robert Saleh’s semi-trustworthy defense, my Seahawks vs 49ers prediction is Under 46.5 Points (-110)

Hindsight informs us that the Eagles defense was overrated in its matchup with the Niners. I carry significantly more faith in the Seahawks defense (-28.5% in weighted DVOA). 

Comparatively, the Eagles posted -13% weighted DVOA rating.

San Francisco averaged 10 points per game against the Seahawks during the regular-season meetings. They’ll also operate without George Kittle, further hampering the offense. 

Kittle also missed the Week 18 contest as the Niners staggered to three points. Now, they get a rested Seahawks defense that directly mitigates its offensive strength. 

San Francisco ranked second in pass offense DVOA, but faces a unit that led the league. Plus, Seattle has rarely looked bad defensively at home when operating at full strength. 

Seattle allowed 37 to the Rams, a historically strong offense by DVOA. While they surrendered 35 to Tampa Bay, Seattle played without both Julian Love and Devon Witherspoon. 

At the same time, I remain concerned about Seattle’s offense. 

The unit has turned into a run-heavy unit, evidenced by 180 yards against San Francisco in Week 18. 

San Francisco, despite overwhelming injury issues, still possesses a corner (Deommodore Lenoir) that can hang with Jaxon Smith-Njigba. 

Presumably, Seattle’s defensive strength will further emphasize the run and burn clock. If Seattle is the lone contributor to the total, I question how a high-scoring game materializes. 

Betting Seahawks vs. 49ers: NFL Public Betting

Team% of ATS Bets% of ATS Money
49ers (+7)69%66%
Seahawks (-7)31%34%

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About the Author Read More @nickhennion

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.