Cardinals vs Pirates Prediction, Odds & Player Prop Bets Today – MLB, Jul 22

Pirates player Andrew McCutchen smiling while running.
(AP Photo/Charles Rex Arbogast)
  • The Pirates are -130 favorites vs the Cardinals
  • Cardinals vs Pirates Over / Under today: 8.5 Runs
  • Cardinals / Pirates TV Channel: BSMW | SNPT

The St. Louis Cardinals (+110) visit PNC Park to take on the Pittsburgh Pirates (-130) on Monday, July 22, 2024. First pitch is scheduled for 6:40pm EDT in Pittsburgh, PA.

This season, the Cardinals are 52-47 against the spread (ATS), while the Pirates are 54-45 ATS.

Cardinals vs Pirates Starting Pitchers Today:

  • Cardinals starting pitcher: Andre Pallante 4-4, 4.18 ERA
  • Pirates starting pitcher: Mitch Keller 10-5, 3.50 ERA

Cardinals vs. Pirates Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals+1.5 -185O 8.5 -115+110
Pirates -1.5 +150U 8.5 -105-130

Cardinals vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Monday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Cardinals vs Pirates and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Brendan Donovan has hit the Home Runs Over in 4 of his last 13 games (+19.50 Units / 150% ROI)
  • Brendan Donovan has hit the Hits Over in 18 of his last 20 games (+15.35 Units / 37% ROI)
  • Nolan Gorman has hit the Total Bases Under in 14 of his last 16 games (+12.40 Units / 64% ROI)
  • Willson Contreras has hit the Singles Under in 14 of his last 17 games (+10.30 Units / 46% ROI)
  • Nolan Gorman has hit the Runs Under in 14 of his last 17 games (+8.95 Units / 31% ROI)

And here are some favorite MLB player prop bets for Pirates players for Monday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

  • Bryan Reynolds has hit the Hits Runs and RBIs Over in 16 of his last 18 games at home (+13.80 Units / 61% ROI)
  • Bryan Reynolds has hit the Home Runs Over in 8 of his last 31 games (+13.45 Units / 43% ROI)
  • Bryan Reynolds has hit the Hits Over in 14 of his last 17 games at home (+12.70 Units / 39% ROI)
  • Bryan Reynolds has hit the Singles Over in 24 of his last 35 games (+11.75 Units / 28% ROI)
  • Ke’Bryan Hayes has hit the Total Bases Under in 12 of his last 13 games (+10.20 Units / 48% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 19 of their last 29 away games (+8.20 Units / 24% ROI)
  • The St. Louis Cardinals have hit the Game Total Over in 19 of their last 29 games (+7.65 Units / 24% ROI)
  • The St. Louis Cardinals have covered the Run Line in 21 of their last 38 games (+6.25 Units / 13% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in their last 5 away games (+5.15 Units / 86% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 17 of their last 29 away games (+5.15 Units / 16% ROI)
  • The Pittsburgh Pirates have hit the Team Total Under in 52 of their last 88 games (+12.30 Units / 12% ROI)
  • The Pittsburgh Pirates have hit the 1st Five Innings (F5) Moneyline in 26 of their last 55 games (+11.50 Units / 17% ROI)
  • The Pittsburgh Pirates have covered the Run Line in 36 of their last 60 games (+10.45 Units / 13% ROI)
  • The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 34 of their last 55 games (+10.20 Units / 15% ROI)
  • The Pittsburgh Pirates have hit the Game Total Under in 24 of their last 37 games (+10.05 Units / 25% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 50-49 against the Run Line (-0.8 Units / -0.61% ROI).

  • 52-47 when betting on the Moneyline for -4.65 Units / -3.83% ROI
  • 46-48 when betting on the total runs Over for -7.15 Units / -6.61% ROI
  • 48-46 when betting on the total runs Under for -2.45 Units / -2.28% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 54-45 against the Run Line (+5.36 Units / 4.15% ROI).

  • 50-49 when betting on the Moneyline for +0.6 Units / 0.52% ROI
  • 45-50 when betting on the total runs Over for -9.85 Units / -8.96% ROI
  • 50-45 when betting on the total runs Under for +1.48 Units / 1.37% ROI

Pirates vs Cardinals Home Run Prop Bets Today

Over Under
Nolan Gorman (STL) 0.5 +475 0.5 -650
Oneil Cruz (PIT) 0.5 +550 0.5 -800
Alec Burleson (STL) 0.5 +600 0.5 -1000
Bryan Reynolds (PIT) 0.5 +625 0.5 -1000
Willson Contreras (STL) 0.5 +625 0.5 -1000

Pirates vs Cardinals Total Hits Prop Bets Today

Over Under
Masyn Winn (STL) 0.5 -275 0.5 +200
Nick Gonzales (PIT) 0.5 -250 0.5 +185
Bryan Reynolds (PIT) 0.5 -250 0.5 +195
Ke'Bryan Hayes (PIT) 0.5 -250 0.5 +175
Brendan Donovan (STL) 0.5 -250 0.5 +195

Pirates vs Cardinals RBI Prop Bets Today

Over Under
Oneil Cruz (PIT) 0.5 +160 0.5 -210
Bryan Reynolds (PIT) 0.5 +165 0.5 -225
Nick Gonzales (PIT) 0.5 +170 0.5 -225
Alec Burleson (STL) 0.5 +170 0.5 -225
Brendan Donovan (STL) 0.5 +170 0.5 -225

Pirates vs Cardinals Strikeout Prop Bets Today

Over Under
Andre Pallante (STL) 3.5 -155 3.5 +120
Mitch Keller (PIT) 5.5 +105 5.5 -140

Andre Pallante has allowed an OBP of .423 (248 PA’s) against right-handed batters since last season — highest among qualified RPs in MLB*; League Avg: .305 — first Percentile.

Left-handed hitters have a groundball rate of 76% (156/205) against Andre Pallante since last season — highest among qualified RPs in MLB*; League Avg: 45% — 100th Percentile.

Right-handed batters are hitting .341 (73-for-214) against Andre Pallante since last season — highest among NL Relievers; League Avg: .232 — first Percentile.

Opponents have a groundball rate of 67% (487/725) against Andre Pallante since the 2022 season — 2nd highest among qualified RPs in MLB*; League Avg: 45% — 99th Percentile.

Pirates Starting Pitcher Stats & Trends

Opponents have a line drive rate of 28% (97/342) against Mitch Keller this season — 4th highest among qualified SPs in MLB; League Avg: 24% — fifth Percentile.

Opponents are hitting .216 (50-for-232) against Mitch Keller with two-strikes this season — tied for 4th highest among qualified SPs in MLB; League Avg: .163 — sixth Percentile.

Mitch Keller has allowed an OBP of .338 (736 PA’s) when going through the lineup the first time in a game since the 2022 season — 2nd highest among qualified SPs in MLB; League Avg: .288 — eighth Percentile.

Opponents are hitting .281 (43-for-153) against Mitch Keller when going through the lineup the second time in a game this season — 6th highest among qualified SPs in MLB; League Avg: .228 — eighth Percentile.

Cardinals Keys to the Game vs. the Pirates

The Cardinals are just 5-21 (.192) when their opponents score in the first inning this season — 2nd lowest in MLB; League Avg: .361.

The Cardinals are 12-8 (.600) after a loss as underdogs this season — tied for 2nd best in MLB; League Avg: .445.

The Cardinals are just 8-115 (.065) when trailing entering the 8th inning since the 2023 season — 5th lowest in MLB; League Avg: .102.

The Cardinals are 33-15 (.688) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

Pirates Keys to the Game vs. the Cardinals

The Pirates are just 16-27 (.372) when tied entering the 8th inning since the 2022 season — 3rd lowest in MLB; League Avg: .500.

The Pirates are just 77-107 (.418) after a win since the 2022 season — 5th lowest in MLB; League Avg: .509.

The Pirates are 15-11 (.577) after a road loss this season — 5th best in MLB; League Avg: .482.

The Pirates are just 5-27 (.156) when allowing 10 or more hits this season — 4th lowest in MLB; League Avg: .245.

Cardinals hitters have an OBP of just .286 (1,088 PA’s) against LHP this season — 2nd lowest in MLB; League Avg: .316.

Cardinals hitters are slugging just .373 against LHP since last season — lowest in MLB; League Avg: .411.

The Cardinals are batting just .224 against LHP this season — 2nd lowest in MLB; League Avg: .248.

Cardinals hitters have an OPS of just .680 (2,648 PA’s) against LHP since last season — 2nd lowest in MLB; League Avg: .732.

Pirates hitters are slugging just .499 on the first pitch of at-bats since the 2022 season — lowest in MLB; League Avg: .574.

Pirates hitters have 62 strikeouts in 168 PA’s (37%) in lefty-lefty matchups this season — highest in MLB; League Avg: 24%.

Pirates hitters have 190 strikeouts in 550 PA’s (34%) in lefty-lefty matchups since last season — highest in MLB; League Avg: 24%.

Pirates hitters have 37 extra-base hits out of 143 total hits (just 26%) on the first pitch of at-bats this season — lowest in MLB; League Avg: 37%.

Cardinals pitchers have walked 13 of 369 batters (4%) over the last 14 days — best in MLB; League Avg: 8%.

Opponents have a groundball rate of 46% against Cardinals pitchers since the 2022 season — 2nd highest in MLB; League Avg: 43%.

Cardinals pitchers have walked 31 of 609 batters (5%) this month (16 games) — best in MLB; League Avg: 8%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Pirates pitchers have walked 1,481 of 16,269 batters (9%) since the 2022 season — 5th highest in MLB; League Avg: 8%.

The Pirates have won 38% of road games in which their opponents scored first this season — 2nd highest in MLB; League Avg: 26%.

Opponents have a groundball rate of 48% against Pirates pitchers this month (16 games) — 3rd highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 48% against Pirates pitchers over the last 14 days — 3rd highest in MLB; League Avg: 43%.

Pirates vs. Cardinals Injuries Tonight That May Affect Prop Bets 

  • Miguel Andujar (Pittsburgh Pirates): Knee, 10-Day IL
  • Colin Holderman (Pittsburgh Pirates): Illness, 15-Day IL
  • Johan Oviedo (Pittsburgh Pirates): Elbow, 60-Day IL
  • Dauri Moreta (Pittsburgh Pirates): Elbow, 60-Day IL
  • Carmen Mlodzinski (Pittsburgh Pirates): Elbow, 15-Day IL
  • Vince Velasquez (Pittsburgh Pirates): Elbow, Out
  • Mike Burrows (Pittsburgh Pirates): Elbow, Out
  • JT Brubaker (Pittsburgh Pirates): Elbow, 60-Day IL
  • Max Kranick (Pittsburgh Pirates): Hamstring, 15-Day IL
  • Endy Rodriguez (Pittsburgh Pirates): Elbow, 60-Day IL
  • Ji Hwan Bae (Pittsburgh Pirates): Hip, 10-Day IL
  • Dylan Carlson (St. Louis Cardinals): Shoulder, 10-Day IL
  • Keynan Middleton (St. Louis Cardinals): Forearm, 15-Day IL
  • Lars Nootbaar (St. Louis Cardinals): Ribs, 10-Day IL
  • Drew Rom (St. Louis Cardinals): Biceps, 15-Day IL
  • Sonny Gray (St. Louis Cardinals): Hamstring, 15-Day IL
  • Riley O’Brien (St. Louis Cardinals): Forearm, 15-Day IL
  • Tommy Edman (St. Louis Cardinals): Wrist, 10-Day IL
  • Packy Naughton (St. Louis Cardinals): Elbow, Out

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About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.