Giants vs Diamondbacks Prediction, Odds & Player Prop Bets Today – MLB, Sep 25

Arizona Diamondbacks designated hitter Lourdes Gurriel Jr. bats during the third inning of a baseball game, Saturday, June 10, 2023, in Detroit.
(AP Photo/Carlos Osorio)
  • The Diamondbacks are -225 favorites vs the Giants
  • Giants vs Diamondbacks Over / Under today: 8.5 Runs
  • Giants / Diamondbacks TV Channel: DBTV | NSBA | MLBN

The San Francisco Giants (+185) visit Chase Field to take on the Arizona Diamondbacks (-225) on Wednesday, September 25, 2024. First pitch is scheduled for 9:40pm EDT in Phoenix, AZ.

This season, the Giants are 79-79 against the spread (ATS), while the Diamondbacks are 82-76 ATS.

Giants vs Diamondbacks Starting Pitchers Today:

  • Giants starting pitcher: Mason Black 1-4, 6.07 ERA
  • Diamondbacks starting pitcher: Zac Gallen 13-6, 3.74 ERA

Giants vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Giants+1.5 -110O 8.5 -110+185
Diamondbacks -1.5 -110U 8.5 -110-225

Giants vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Wednesday‘s MLB game with 65.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

  • Michael Conforto has hit the Home Runs Over in 8 of his last 23 away games (+29.00 Units / 126% ROI)
  • LaMonte Wade Jr has hit the Hits Under in 16 of his last 25 away games (+11.20 Units / 40% ROI)
  • Matt Chapman has hit the Singles Under in his last 10 games (+10.00 Units / 71% ROI)
  • Michael Conforto has hit the Total Bases Over in 11 of his last 12 away games (+10.00 Units / 54% ROI)
  • Jerar Encarnacion has hit the Hits Runs and RBIs Over in 10 of his last 11 away games (+9.45 Units / 80% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Wednesday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

  • Corbin Carroll has hit the Home Runs Over in 9 of his last 38 games (+34.10 Units / 90% ROI)
  • Geraldo Perdomo has hit the Runs Over in 29 of his last 50 games (+20.15 Units / 40% ROI)
  • Corbin Carroll has hit the Hits Over in 17 of his last 19 games at home (+13.40 Units / 34% ROI)
  • Eugenio Suarez has hit the Singles Over in 13 of his last 17 games (+12.50 Units / 72% ROI)
  • Josh Bell has hit the Total Bases Over in 14 of his last 19 games at home (+12.05 Units / 53% ROI)
  • The San Francisco Giants have hit the Game Total Over in 46 of their last 80 away games (+14.35 Units / 16% ROI)
  • The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 26 of their last 39 away games (+11.55 Units / 24% ROI)
  • The San Francisco Giants have hit the Moneyline in 18 of their last 28 away games (+11.35 Units / 36% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 31 of their last 49 away games (+10.43 Units / 18% ROI)
  • The San Francisco Giants have covered the Run Line in 9 of their last 10 away games (+8.50 Units / 61% ROI)
  • The Arizona Diamondbacks have hit the Game Total Over in 67 of their last 102 games (+32.40 Units / 29% ROI)
  • The Arizona Diamondbacks have hit the Moneyline in 62 of their last 101 games (+18.50 Units / 14% ROI)
  • The Arizona Diamondbacks have covered the Run Line in 54 of their last 93 games (+13.50 Units / 11% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 33 games (+8.55 Units / 22% ROI)
  • The Arizona Diamondbacks have hit the Team Total Over in 20 of their last 30 games at home (+8.20 Units / 23% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 80-78 against the Run Line (-4.9 Units / -2.37% ROI).

  • 79-79 when betting on the Moneyline for -8.3 Units / -4.13% ROI
  • 80-71 when betting on the total runs Over for +2.25 Units / 1.3% ROI
  • 71-80 when betting on the total runs Under for -17 Units / -9.76% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 82-76 against the Run Line (-0.9 Units / -0.43% ROI).

  • 87-71 when betting on the Moneyline for +8.75 Units / 4.34% ROI
  • 90-62 when betting on the total runs Over for +21.05 Units / 12.03% ROI
  • 62-90 when betting on the total runs Under for -36.75 Units / -21.27% ROI

Diamondbacks vs Giants Home Run Prop Bets Today

Over Under
Joc Pederson (ARI) 0.5 +360 0.5 -500
Christian Walker (ARI) 0.5 +400 0.5 -550
Matt Chapman (SF) 0.5 +400 0.5 -550
Ketel Marte (ARI) 0.5 +425 0.5 -600
Eugenio Suarez (ARI) 0.5 +450 0.5 -650

Diamondbacks vs Giants Total Hits Prop Bets Today

Over Under
Lourdes Gurriel Jr (ARI) 0.5 -275 0.5 +195
Jake McCarthy (ARI) 0.5 -275 0.5 +210
Christian Walker (ARI) 0.5 -250 0.5 +175
Ketel Marte (ARI) 0.5 -250 0.5 +190
Joc Pederson (ARI) 0.5 -225 0.5 +165

Diamondbacks vs Giants RBI Prop Bets Today

Over Under
Christian Walker (ARI) 0.5 +125 0.5 -160
Joc Pederson (ARI) 0.5 +130 0.5 -175
Eugenio Suarez (ARI) 0.5 +140 0.5 -185
Ketel Marte (ARI) 0.5 +140 0.5 -185
Matt Chapman (SF) 0.5 +145 0.5 -190

Diamondbacks vs Giants Strikeout Prop Bets Today

Over Under
Mason Black (SF) 3.5 -115 3.5 -115
Zac Gallen (ARI) 6.5 +110 6.5 -145

Mason Black had a first-pitch strike rate of just 32% (7/22) in his last start — lowest in MLB over the last week; League Avg: 65% — first Percentile.

Opponents have a miss rate of just 17% (23/137) against Mason Black this month (3 games) — 9th lowest in MLB among starting pitchers with at least 7 total IP; League Avg: 26% — fifth Percentile.

Mason Black has a strikeout rate of 37% (10 SO in 27 PAs) when going through the lineup the second time in a game this month (3 games) — 5th best in MLB among starting pitchers with at least 7 total IP; League Avg: 22% — 96th Percentile.

Left-handed hitters have a groundball rate of just 27% (6/22) against Mason Black this month (3 games) — 7th lowest in MLB among starting pitchers with at least 7 total IP; League Avg: 41% — seventh Percentile.

Diamondbacks Starting Pitcher Stats & Trends

Zac Gallen has walked 7 of 36 batters (19%) when going through the lineup the first time in a game this month (4 games) — highest among among NL Starters; League Avg: 7% — second Percentile.

Zac Gallen has walked 7 of 36 batters (19%) when going through the lineup the first time in a game this month (4 games) — tied for 2nd highest among qualified SPs in MLB; League Avg: 7% — third Percentile.

Hitters have swung at 44% of Zac Gallen’s pitches (66/149) with two-strikes this month (4 games) — lowest among qualified SPs in MLB; League Avg: 59% — first Percentile.

Zac Gallen has allowed an OBP of just .271 (811 PA’s) when going through the lineup the second time in a game since the 2022 season — 4th best among qualified SPs in MLB; League Avg: .295 — 87th Percentile.

Giants Keys to the Game vs. the Diamondbacks

The Giants are 30-200 (.130) when trailing entering the 8th inning since the 2022 season — tied for 4th best in MLB; League Avg: .095.

The Giants are just 35-49 (.417) after a road loss since the 2023 season — 5th lowest in MLB; League Avg: .475.

The Giants are 22-135 (.140) when trailing entering the 8th inning since the 2023 season — tied for 5th best in MLB; League Avg: .100.

The Giants are just 51-77 (.398) after a road loss since the 2022 season — 5th lowest in MLB; League Avg: .465.

Diamondbacks Keys to the Game vs. the Giants

The Diamondbacks are 20-16 (.556) when their opponents score in the first inning this season — best in MLB; League Avg: .358.

The Diamondbacks are 18-11 (.621) after a home loss this season — 5th best in MLB; League Avg: .531.

The Diamondbacks are just 188-30 (.862) when leading entering the 8th inning since the 2022 season — 4th lowest in MLB; League Avg: .905.

The Diamondbacks are 29-178 (.139) when trailing entering the 8th inning since the 2022 season — 2nd best in MLB; League Avg: .095.

Giants hitters have 1,343 strikeouts in 5,380 PA’s (25%) against LHP since the 2022 season — 3rd highest in MLB; League Avg: 23%.

Giants hitters have 864 strikeouts in 3,448 PA’s (25%) against LHP since last season — 4th highest in MLB; League Avg: 23%.

Giants hitters have an OBP of just .300 (4,261 PA’s) against RHP this season — tied for 4th lowest in MLB; League Avg: .312.

The Giants are batting just .237 since last season — tied for 5th lowest in MLB; League Avg: .246.

The Diamondbacks are batting .283 against LHP this season — best in MLB; League Avg: .245.

Diamondbacks hitters have an OBP of .346 (2,924 PA’s) at home this season — best in MLB; League Avg: .315.

Diamondbacks hitters have an OBP of .345 (1,943 PA’s) against LHP this season — tied for best in MLB; League Avg: .314.

Diamondbacks hitters are slugging .315 with two-strikes this season — best in MLB; League Avg: .265.

Opponents have a groundball rate of 49% against Giants pitchers since the 2022 season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since last season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers this season — highest in MLB; League Avg: 43%.

Giants pitchers have walked 183 of 2,841 batters (6%) when facing the leadoff batter in the inning since last season — 2nd best in MLB; League Avg: 8%.

The Diamondbacks pitchers have allowed their opponents to score first in just 39% of their games at home this season — lowest in MLB; League Avg: 56%.

The Diamondbacks pitchers have allowed division opponents to score first in just 31% of their games this season — 2nd lowest in MLB; League Avg: 50%.

The Diamondbacks pitchers have allowed their opponents to score first in just 35% of their games this season — lowest in MLB; League Avg: 50%.

Opponents have a miss rate of just 24% against Diamondbacks pitchers since the 2022 season — 5th lowest in MLB; League Avg: 26%.

Diamondbacks vs. Giants Injuries Tonight That May Affect Prop Bets 

  • Arizona Diamondbacks – No Injuries Reported
  • San Francisco Giants – No Injuries Reported

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About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.