Winthrop vs Louisville Prediction, Odds & Best Bets Today – NCAAB, Nov. 22

Louisville head coach Kenny Payne argues with a game official during the first half of an NCAA college basketball game against Wake Forest in Louisville, Ky., Saturday, Jan. 7, 2023.
(AP Photo/Timothy D. Easley)
  • Louisville is a -20.5 point favorite vs Winthrop
  • Total (Over/Under): 156.5 points
  • Winthrop / Louisville TV channel: ESPN+ | ACCN

The Winthrop Eagles visit KFC Yum! Center to take on the Louisville Cardinals on Nov. 22. Tip off is scheduled for 7:00pm EST in Louisville, KY.

Louisville is the betting favorite in this game, with the spread sitting at -20.5 (-105).

The Winthrop vs. Louisville Over/Under is 156.5 total points.

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Winthrop vs. Louisville Odds, Spread, Over/Under

SpreadTotal (O/U)Moneyline
Winthrop+20.5 -115O 156.5 -105+1250
Louisville -20.5 -105U 156.5 -115-3000

Winthrop vs Louisville Prediction for Today:

The winning team model predicts Louisville will win this college basketball game with 80.0% confidence, based on game simulations, player injuries, key player performances and recent matchups.

Winthrop vs Louisville Spread Prediction:

Based on recent against-the-spread trends, the spread model predicts Louisville will cover the spread with 61.9% confidence for today’s game.


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  • Winthrop have covered the 1H Spread in 11 of their last 15 away games (+6.55 Units / 39% ROI)
  • Winthrop has hit the Team Total Over in 11 of their last 15 away games (+6.30 Units / 36% ROI)
  • Winthrop has hit the Game Total Over in 17 of their last 29 games (+3.70 Units / 12% ROI)
  • Winthrop have covered the Spread in 9 of their last 15 away games (+2.40 Units / 15% ROI)
  • Winthrop has hit the 1H Moneyline in 8 of their last 15 away games (+2.30 Units / 12% ROI)
  • Louisville has hit the Team Total Over in 11 of their last 18 games at home (+3.15 Units / 15% ROI)
  • Louisville has hit the Game Total Under in 16 of their last 30 games (+0.60 Units / 2% ROI)
  • Louisville has hit the 1H Game Total Under in 10 of their last 18 games at home (+0.55 Units / 3% ROI)

Winthrop Basketball Against the Spread Record (ATS)

Winthrop has a 2-3 record against the spread this college basketball season (-1.3 Units / -23.64% ROI).

  • 3-2 when betting on the Moneyline for -0.2 Units / -1.21% ROI
  • 3-2 when betting the Over for +0.8 Units / 14.55% ROI
  • 2-3 when betting the Under for -1.3 Units / -23.64% ROI

Louisville Basketball Against the Spread Record (ATS)

Louisville has a 2-1 record against the spread this college basketball season (+0.9 Units / 27.27% ROI).

  • 2-1 when betting on the Moneyline for +0.5 Units / 0.41% ROI
  • 1-2 when betting the Over for -1.2 Units / -36.36% ROI
  • 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Winthrop Offensive Stats & Trends:

Winthrop had 26.8 free throw attempts per game last season — best among Division 1 Teams; League Avg: 19.2

Winthrop averaged 49% free throw attempts for every field goal attempt (832 free throw attempts/1,707 field goal attempts) last season — highest among Big South Teams; League Avg: 37%

Winthrop averaged 1.40 points per shot (2,394 points/1,707 shots) last season — best among Big South Teams; League Avg: 1.29

Winthrop shot 34% from three (235/686) last season — 4th best among Big South Teams; League Avg: 34%

Louisville Offensive Stats & Trends:

Louisville averaged 5.0 assists per game (154 assists/31 games) in the first half last season — lowest among ACC Teams; League Avg: 6.8

Louisville had an assist to turnover ratio of 0.7 (154 assists/ 231 TOs) in the first half last season — lowest among ACC Teams; League Avg: 1.2

Louisville had an assist to turnover ratio of 0.9 (343 assists/ 398 TOs) last season — 2nd lowest among ACC Teams; League Avg: 1.3

Louisville made 5.5 three-pointers per game last season — tied for 16th lowest among Division 1 Teams; League Avg: 7.5

Winthrop Defensive Stats & Trends:

Winthrop averaged 23.4 defensive rebounds per game (724 rebounds/31 games) last season — 5th lowest among Big South Teams; League Avg: 23.7

Winthrop allowed opponents to shoot 42% (761/1,812) last season — best among Big South Teams ; League Avg: 44%

Winthrop stole the ball 199 times last season — 4th most among Big South Teams

Winthrop averaged 6.4 steals per game (199 steals/31 games) last season — 4th best among Big South Teams; League Avg: 6.0

Louisville Defensive Stats & Trends:

Louisville allowed an average of 1.35 points per shot (2,463 points/1,827 shots) last season — tied for highest among Division 1 Teams; League Avg: 1.23

Louisville allowed opponents to shoot 48% (872/1,827) last season — 4th highest among Division 1 Teams; League Avg: 44%

Louisville allowed an average of 1.35 points per shot (2,463 points/1,827 shots) last season — highest among ACC Teams; League Avg: 1.22

Louisville allowed opponents to shoot 48% (450/927) in the first half last season — highest among ACC Teams; League Avg: 43%


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.