After a wild Week 2, NFL betting is back in Week 3 with 16 games and thousands of different odds.
NFL Odds Week 3: Biggest NFL Spreads This Week
| Rank | Matchup | Spread |
| 1 | Chicago Bears vs. Kansas City Chiefs | Chiefs (-13) |
| 2 | Dallas Cowboys vs. Arizona Cardinals | Cowboys (-12.5) |
| 3 | New York Giants vs. San Francisco 49ers | 49ers (-10.5) |
| 4 | Houston Texans vs. Jacksonville Jaguars | Jaguars (-9.5) |
| 5 | Indianapolis Colts vs. Baltimore Ravens | Ravens (-7.5) |
| 6. (Tie) | Denver Broncos vs. Miami Dolphins | Dolphins (-6.5) |
| 6. (Tie) | Buffalo Bills vs. Washington Commanders | Bills (-6.5) |
| 8 | Philadelphia Eagles vs. Tampa Bay Buccaneers | Eagles (-6) |
| 9. (Tie) | Tennessee Titans vs. Cleveland Browns | Browns (-3.5) |
| 9. (Tie) | Atlanta Falcons vs. Detroit Lions | Lions (-3.5) |
1. Chicago Bears vs. Kansas City Chiefs (-13)
Week 3’s biggest favorite has the Kansas City Chiefs hosting the Chicago Bears as a 13-point favorite. The Chiefs have posted a 1-1 record against the spread in 2023, averaging 18.5 points per game.
2. Dallas Cowboys (-12.5) vs. Arizona Cardinals
The Dallas Cowboys have outscored their opponents 70-10 through two weeks of action, covering the spread in both contests. The Cowboys are hitting the road in Week 3 as a 12.5-point favorite against the Arizona Cardinals.
3. New York Giants vs. San Francisco 49ers (-10.5)
The San Francisco 49ers have won each of their first two games by a touchdown or more. The 49ers are set to kick off their home schedule when they host the New York Giants as a 10.5-point favorite. The 49ers are 1-1 against the spread in 2023.
4. Houston Texans vs. Jacksonville Jaguars (-9.5)
Despite dropping their Week 2 matchup against the Kansas City Chiefs, the Jacksonville Jaguars are still listed as a near double-digit favorite in Week 3 at home against the Houston Texans. The Jaguars are 1-1 against the spread in 2023 and are 9.5-point favorites in this matchup.
5. Indianapolis Colts vs. Baltimore Ravens (-7.5)
The Baltimore Ravens have flown out to a 2-0 start, and they’re set to host the Indianapolis Colts as a 7.5-point favorite in Week 3. The Ravens have covered the spread in both of their first two games.
6. (Tie) Denver Broncos vs. Miami Dolphins (-6.5)
It’s been an impressive start to the regular season for the Miami Dolphins, who’ve posted a 2-0 record and covered the spread in both games. The Dolphins are listed as a 6.5-point home favorite against the Denver Broncos in Week 3.
6. (Tie) Buffalo Bills (-6.5) vs. Washington Commanders
After losing in Week 1 to the New York Jets, the Buffalo Bills bounced back in Week 2 and blew the doors off the Las Vegas Raiders while covering the number. The Bills are headed on the road in Week 3 as a 6.5-point favorite against the Washington Commanders.
8. Philadelphia Eagles (-6) vs. Tampa Bay Buccaneers
The Philadelphia Eagles have shot out of the gate with a 2-0 start and are set to host the Tampa Bay Buccaneers in a battle of undefeated teams in Week 3. The Eagles are listed as six-point road favorites and are 1-0-1 against the spread in 2023.
9. (Tie) Tennessee Titans vs. Cleveland Browns (-3.5)
It’s a short week for the Cleveland Browns after battling the Pittsburgh Steelers on Monday Night Football, but they’re still listed as a 3.5-point home favorite on Sunday against the Tennessee Titans.
9. (Tie) Atlanta Falcons vs. Detroit Lions (-3.5)
The Detroit Lions are set to clash with the 2-0 Atlanta Falcons in Week 3 action at home. The Lions are listed as a 3.5-point favorite in this matchup and are 1-1 against the spread in 2023.
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