- Here are the biggest spreads in Week 6.
- Georgia is a 29.5-point favorite against Auburn.
Week 6 should be an exciting one in college football, with some big matchups.
Here’s a look at the college football odds to see who the largest favorites are this weekend.
College Football Odds Week 6: Biggest NCAAF Spreads This Week
| Rank | Matchup | Spread |
|---|---|---|
| 1 | Auburn at Georgia | Georgia -29.5 |
| 2 | South Florida at Cincinnati | Cincinnati -27.5 |
| 3 | Liberty at Massachusetts | Liberty -25.5 |
| T4 | Ohio State at Michigan State | Ohio State -24.5 |
| T4 | Texas A&M at Alabama | Alabama -24.5 |
| 6 | Michigan at Indiana | Michigan -21.5 |
| 7 | Clemson at Boston College | Clemson -20.5 |
| 8 | Appalachian State at Texas State | Appalachian State -19.5 |
| 9 | Ole Miss at Vanderbilt | Ole Miss -18.5 |
| 10 | Army at Wake Forest | Wake Forest -15.5 |
1. Auburn at Georgia (-28.5)
The Auburn Tigers (3-2) have a lame duck head coach, and it’s only a matter of time before Bryan Harsin is fired (here’s a look at Harsin’s contract), so this season could get ugly in a hurry. The Georgia Bulldogs (5-0) look to get back on track after almost falling to the Missouri Tigers last week and looking unimpressive for two straight games.
2. South Florida at Cincinnati (-27.5)
The Jeff Scott era has been a disaster for the South Florida Bulls (1-4), as they are just 4-22 overall. Year 3 could be his last if things don’t turn around in a hurry, and another formidable opponent awaits in the Cincinnati Bearcats (4-1).
3. Liberty (-25.5) at Massachusetts
Hugh Freeze continues his masterful coaching job at Liberty as the Flames are 4-1, with their only loss coming by one point to Wake Forest.
T4. Ohio State (-24.5) at Michigan State
Mel Tucker and the Michigan State Spartans (2-3) have already lost more games than they did a season ago. The going doesn’t get any easier in Week 6, as the Ohio State Buckeyes (5-0) come to town. The Buckeyes lead the nation averaging 48.8 points per game.
T4. Texas A&M at Alabama (-24.5)
The Alabama Crimson Tide (5-0) are on the hunt for revenge after falling in this matchup a year ago. All eyes will be on quarterback Bryce Young, who left last week’s game with a throwing shoulder injury, and Nick Saban, who Jimbo Fisher pestered for most of the offseason. Another blowout loss and Fisher could firmly be on the college football hot seat.
6. Michigan (-21.5) at Indiana
Jim Harbaugh and the Michigan Wolverines (5-0) are averaging 45.4 points per game offensively while allowing just 11.6 points per game defensively. Will that dominance carry over into Big Ten play?
7. Clemson (-20.5) at Boston College
Dabo Swinney and the Clemson Tigers (5-0) are rolling. This is a potential letdown spot after monumental victories over the Wake Forest Demon Deacons and NC State Wolfpack over the last two weeks.
8. Appalachian State (-19.5) at Texas State
The Texas State Bobcats (2-3) are one of the worst teams in the country, and Jake Spavital is firmly on the college football hot seat.
9. Ole Miss (-18.5) at Vanderbilt
The Lane Train kept chugging in Week 5 with a home victory over the Kentucky Wildcats. The Ole Miss Rebels (5-0) look to stay undefeated and are a three-score favorite in Week 6.
10. Army at Wake Forest (-15.5)
Wake Forest is 4-1, with its only loss coming in overtime to Clemson. A year ago, this game was a shootout when the Demon Deacons pulled off a 70-56 win at West Point.
College Football Betting at BetMGM
College football betting is a unique way to add more excitement each Saturday.
Football betting opportunities are available for hundreds of FBS and FCS games each year, including Alabama vs. Auburn in the Iron Bowl, Oregon and Oregon State in the Civil War, and the Army-Navy Game.
Whether you’re looking for moneyline parlays, over/under totals, or futures, there’s something for everyone at the online sportsbook.
