College Football Odds Week 6: Biggest NCAAF Spreads This Week

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Georgia quarterback Stetson Bennett (13) rolls out to pass against Kentucky during the first half of an NCAA college football game Saturday, Oct. 16, 2021 in Athens, Ga.
(AP Photo/Butch Dill)
BetMGM Staff @BETMGM Oct 03, 2022, 12:45 PM
  • Here are the biggest spreads in Week 6.
  • Georgia is a 29.5-point favorite against Auburn.

Week 6 should be an exciting one in college football, with some big matchups.

Here’s a look at the college football odds to see who the largest favorites are this weekend.

College Football Odds Week 6: Biggest NCAAF Spreads This Week

RankMatchupSpread
1Auburn at GeorgiaGeorgia -29.5
2South Florida at CincinnatiCincinnati -27.5
3Liberty at MassachusettsLiberty -25.5
T4Ohio State at Michigan StateOhio State -24.5
T4Texas A&M at AlabamaAlabama -24.5
6Michigan at IndianaMichigan -21.5
7Clemson at Boston CollegeClemson -20.5
8Appalachian State at Texas StateAppalachian State -19.5
9Ole Miss at VanderbiltOle Miss -18.5
10Army at Wake ForestWake Forest -15.5

1. Auburn at Georgia (-28.5)

The Auburn Tigers (3-2) have a lame duck head coach, and it’s only a matter of time before Bryan Harsin is fired (here’s a look at Harsin’s contract), so this season could get ugly in a hurry. The Georgia Bulldogs (5-0) look to get back on track after almost falling to the Missouri Tigers last week and looking unimpressive for two straight games.

2. South Florida at Cincinnati (-27.5)

The Jeff Scott era has been a disaster for the South Florida Bulls (1-4), as they are just 4-22 overall. Year 3 could be his last if things don’t turn around in a hurry, and another formidable opponent awaits in the Cincinnati Bearcats (4-1).

3. Liberty (-25.5) at Massachusetts

Hugh Freeze continues his masterful coaching job at Liberty as the Flames are 4-1, with their only loss coming by one point to Wake Forest.

T4. Ohio State (-24.5) at Michigan State

Mel Tucker and the Michigan State Spartans (2-3) have already lost more games than they did a season ago. The going doesn’t get any easier in Week 6, as the Ohio State Buckeyes (5-0) come to town. The Buckeyes lead the nation averaging 48.8 points per game.

T4. Texas A&M at Alabama (-24.5)

The Alabama Crimson Tide (5-0) are on the hunt for revenge after falling in this matchup a year ago. All eyes will be on quarterback Bryce Young, who left last week’s game with a throwing shoulder injury, and Nick Saban, who Jimbo Fisher pestered for most of the offseason. Another blowout loss and Fisher could firmly be on the college football hot seat.

6. Michigan (-21.5) at Indiana

Jim Harbaugh and the Michigan Wolverines (5-0) are averaging 45.4 points per game offensively while allowing just 11.6 points per game defensively. Will that dominance carry over into Big Ten play?

7. Clemson (-20.5) at Boston College

Dabo Swinney and the Clemson Tigers (5-0) are rolling. This is a potential letdown spot after monumental victories over the Wake Forest Demon Deacons and NC State Wolfpack over the last two weeks.

8. Appalachian State (-19.5) at Texas State

The Texas State Bobcats (2-3) are one of the worst teams in the country, and Jake Spavital is firmly on the college football hot seat.

9. Ole Miss (-18.5) at Vanderbilt

The Lane Train kept chugging in Week 5 with a home victory over the Kentucky Wildcats. The Ole Miss Rebels (5-0) look to stay undefeated and are a three-score favorite in Week 6.

10. Army at Wake Forest (-15.5)

Wake Forest is 4-1, with its only loss coming in overtime to Clemson. A year ago, this game was a shootout when the Demon Deacons pulled off a 70-56 win at West Point.

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Our BetMGM authors are sports experts, with a wealth of knowledge of the sports betting industry at all levels. Their coverage includes sports news across players, teams and coaches, providing betting previews and predictions, fun facts and more.

Our BetMGM authors are sports experts, with a wealth of knowledge of the sports betting industry at all levels. Their coverage includes sports news across players, teams and coaches, providing betting previews and predictions, fun facts and more.