Vanderbilt vs Missouri Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 4

Missouri head coach Eliah Drinkwitz yells during the second half of the team's Cotton Bowl NCAA college football game against Ohio State on Friday, Dec. 29, 2023, in Arlington, Texas. (AP Photo/Julio Cortez)
(AP Photo/Julio Cortez)
  • Missouri is a -20.5 point favorite vs. Vanderbilt
  • Vanderbilt vs. Missouri Total(Over/Under): 53.5 points
  • TV Channel: SECN

The Vanderbilt Commodores (2-1) visit Memorial Stadium/Faurot Field to take on the Missouri Tigers (3-0) on Sep. 21 in Columbia, MO. Kickoff is scheduled for 4:15pm EDT.

Missouri is a betting favorite in Week 4, with the spread sitting at -20.5 (-115).

The Vanderbilt vs. Missouri Over/Under is 53.5 total points.

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Vanderbilt vs. Missouri Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Vanderbilt+20.5 -10553.5 -110+900
Missouri -20.5 -11553.5 -110-1600

Vanderbilt vs Missouri Prediction:

The winning team model predicts Missouri will win this game with 93.4% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Vanderbilt and Missouri, key player performances this season and recent team trends.

Vanderbilt vs Missouri Spread Prediction:

Based on recent against-the-spread trends, the model predicts Missouri will cover the spread with 62.8% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Vanderbilt has hit the Game Total Over in 8 of their last 11 games (+4.70 Units / 39% ROI)
  • Vanderbilt has hit the 1H Game Total Under in 3 of their last 5 away games (+0.80 Units / 14% ROI)
  • Vanderbilt has hit the 1Q Game Total Under in 3 of their last 5 away games (+0.70 Units / 12% ROI)
  • Missouri has hit the 1H Moneyline in 9 of their last 11 games (+8.60 Units / 34% ROI)
  • Missouri has hit the Moneyline in 9 of their last 11 games (+7.75 Units / 26% ROI)
  • Missouri have covered the Spread in 9 of their last 12 games (+5.75 Units / 44% ROI)
  • Missouri have covered the 1H Spread in 9 of their last 12 games (+5.70 Units / 43% ROI)
  • Missouri has hit the 1H Game Total Under in 8 of their last 12 games (+3.85 Units / 29% ROI)

We’ve highlighted some favorite college football player prop bets for Vanderbilt players, looking at profitable historical betting trends:

Best Vanderbilt Player Prop Bets Today

  • Diego Pavia has hit the TD Passes Over in his last game (+1.00 Units / 45% ROI)

Top NCAAF player prop bets for Missouri players, looking at profitable historical betting trends:

Best Missouri Player Prop Best Bets Today

  • Brady Cook has hit the TD Passes Under in 6 of his last 7 games (+5.25 Units / 52% ROI)
  • Luther Burden III has hit the Receiving Yards Under in 6 of his last 7 games (+4.80 Units / 57% ROI)
  • Mookie Cooper has hit the Receiving Yards Under in his last 4 games (+4.00 Units / 83% ROI)
  • Brady Cook has hit the Passing Yards Over in 4 of his last 5 games at home (+2.80 Units / 47% ROI)
  • Theo Wease Jr. has hit the Receiving Yards Over in 6 of his last 9 games (+2.40 Units / 22% ROI)

Vanderbilt Against the Spread (ATS) Record

Vanderbilt is 2-1 against the spread this college football season (+0.9 Units / 27.27% ROI).

  • Vanderbilt is 1-1 when betting on the Moneyline for +0.55 Units / 12.36% ROI
  • Vanderbilt is 3-0 when betting the Over for +3 Units / 90.91% ROI
  • Vanderbilt is 0-3 when betting the Under for -3.3 Units / -100% ROI

Missouri Against the Spread (ATS) Record

Missouri is 1-1 against the spread this college football season (-0.05 Units / -2.33% ROI).

  • Missouri is 1-0 when betting on the Moneyline for +1 Units / 16.53% ROI
  • Missouri is 0-2 when betting the Over for -2.2 Units / -100% ROI
  • Missouri is 2-0 when betting the Under for +2 Units / 90.91% ROI

Vanderbilt: Keys to the Game vs. Missouri

Vanderbilt is 1-9 (.077) when averaging less than 5 yards per rush since the 2023 season– T-4th-worst among Power Conference Teams; Average: .365

Vanderbilt is 1-10 (.091) when allowing 100 or more rushing yards since the 2023 season– T-10th-worst in FBS; Average: .391

Vanderbilt is 1-9 (.100) when having a turnover margin within one of the opposing team since the 2023 season– T-6th-worst in FBS; Average: .497

Vanderbilt is 1-8 (.111) when allowing 10 or more rushes of four or more yards since the 2023 season– T-6th-worst among Power Conference Teams; Average: .453

Missouri: Keys to the Game vs. Vanderbilt

Missouri is 6-1 (.667) when committing less than 60 yards in penalties since the 2023 season– T-17th-best in FBS; Average: .441

Missouri is undefeated (9-0) when not throwing an interception since the 2023 season– T-6th-best in FBS; Average: .589

Missouri is 11-1 (.786) when rushing more than 30 times since the 2023 season– 16th-best in FBS; Average: .517

Missouri is 9-1 (.900) when allowing less than 50% of third down conversion opportunities since the 2023 season– 5th-best among Power Conference Teams; Average: .559

Matchup Notes for Vanderbilt vs. Missouri

Missouri’s offense has thrown for 20 or more yards on just 6.2% of 113 attempts this season — T-15th-worst among FBS offenses. Vanderbilt’s defense allowed 20+ yards on 11.0% of attempts this season — 4th-best among SEC defenses.

Missouri’s QBs has thrown for 4,175 passing yards in 16 games (260.9 YPG) since the 2023 season — 33rd-best among FBS teams. Vanderbilt’s defense has allowed 265.1 passing yards per game since the 2023 season — 9th-worst among FBS defenses.

Missouri has just 1.6 receiving touchdowns per game since the 2023 season — 3rd-worst among SEC skill players. Vanderbilt’s defense has allowed 2.1 receiving touchdowns per game since the 2023 season — T-8th-worst among FBS defenses.

Vanderbilt’s QBs has thrown for 543 passing yards in 3 games (just 181.0 YPG) this season — 33rd-worst among FBS teams. Missouri’s defense has allowed just 110.3 passing yards per game this season — 3rd-best among SEC defenses.

Vanderbilt has gained 559 yards on 40 receptions (14.0 YPR) this season — T-31st-best among FBS skill players. Missouri’s defense has allowed 11.4 Yards Per Reception this season — 4th-worst among SEC defenses.

Vanderbilt’s QBs has thrown for 543 passing yards in 3 games (just 181.0 YPG) this season — 33rd-worst among FBS teams. Missouri’s defense has allowed just 110.3 passing yards per game this season — 7th-best among FBS defenses.

Vanderbilt Offensive Stats & Trends

Vanderbilt Skill Players have averaged just 3.8 yards per reception (34 yards/9 catches) on 3rd and short since the 2022 season– worst among SEC Teams; Average: 10.6

Vanderbilt TEs have been targeted 8.0 times per game (16/2) in the 2nd half this season– highest among FBS Teams; Average: 2.5

Vanderbilt TEs have picked up first downs on 5 receptions in the 4th quarter this season– most among SEC Teams

Vanderbilt TEs have 6 receptions in close and late situations this season– most among SEC Teams

Vanderbilt TEs have 6 receptions in the 4th quarter this season– most among SEC Teams

Missouri Offensive Stats & Trends

Missouri Skill Players have averaged a touchdown every 42.0 receptions (84 Rec/2 TDs) this season– worst Receptions Per TD among SEC Teams; Average: 8.9

Missouri Skill Players have averaged a touchdown every 42.0 receptions (84 Rec/2 TDs) this season– 2nd-worst Receptions Per TD among Power Conference Teams; Average: 10.2

Missouri’s offense has thrown for 20 or more yards on just 6.2% of 113 attempts this season — T-15th-worst among FBS offenses. Vanderbilt’s defense allowed 20+ yards on 11.0% of attempts this season — 4th-best among SEC defenses.

Missouri Skill Players have averaged a touchdown every 42.0 receptions (84 Rec/2 TDs) this season– 5th-worst Receptions Per TD among FBS Teams; Average: 10.9

Missouri’s QBs has thrown for 4,175 passing yards in 16 games (260.9 YPG) since the 2023 season — 33rd-best among FBS teams. Vanderbilt’s defense has allowed 265.1 passing yards per game since the 2023 season — 9th-worst among FBS defenses.

Vanderbilt Commodores Defensive Stats & Trends

Vanderbilt has not forced a fumble (92 carries) this season– T-worst in FBS; Average: 43.0

Vanderbilt has allowed 239.7 yards from scrimmage per game to WRs since the 2022 season– worst in the SEC; Average: 168.9

Vanderbilt has allowed 57 TD passes since the 2022 season– most in the SEC

Vanderbilt has allowed 234.7 receiving yards per game (5,868/25) to WRs since the 2022 season– worst in FBS; Average: 165.9

Vanderbilt has allowed 8.1 yards from scrimmage per touch (11,392 yards / 1,409 touches) since the 2022 season– worst in the SEC; Average: 6.7

Missouri Tigers Defensive Stats & Trends

Missouri has allowed 8 rushing TDs on 514 carries (64.2 Carries Per TD) since the 2023 season– 4th-best in FBS; Average: 24.7

Missouri has allowed 6 rushing TDs on 61 carries (10.2 Carries Per TD) in the Red Zone since the 2023 season– 3rd-best in FBS; Average: 4.7

Missouri has allowed a Completion Pct of just 46% (29 completions/63 attempts) this season– best in the SEC; Average: 60%

Missouri allowed 6 rushing TDs on 60 carries (10 Carries Per TD) in the Red Zone in the 2023 season– 4th-best in FBS; Average: 4.7

Missouri has no interceptions and 16 TD passes allowed in the Red Zone since the 2023 season– T-worst in FBS; Average: 9.9


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About the Author

Nick Hennion

Read More @nickhennion

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.