How to Bet on Week 1 NFL Odds

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(Photo by Jamie Squire/Getty Images)
BetMGM Jul 28, 2021, 8:03 AM

The NFL is back with a 17-game season, packed stadiums, Tom Brady in possession of another Lombardi Trophy, the Buffalo Bills chasing the Kansas City Chiefs, and more betting opportunities than ever with Week 1 NFL odds.

At BetMGM, you can view updated odds for each Week 1 game, including Brady and the Tampa Bay Buccaneers hosting Dak Prescott and the Dallas Cowboys on Thursday night and Stefon Diggs and the Buffalo Bills visiting Ben Roethlisberger and the Pittsburgh Steelers on Sunday afternoon.

Week 1 NFL Odds

Minutes after the 2021 NFL schedule was released on May 12, Week 1 NFL odds were posted for BetMGM customers. You can view the spread, money line, over/under total, and more for each of the 16 games on the NFL betting page (odds as of July 13):

Dallas Cowboys at Tampa Bay Buccaneers

Date: Thursday, Sept. 9
Time: 8:20 PM ET 
Spread: Bucs -6.5

One year after a season-opening road loss to the New Orleans Saints, the Buccaneers open the 2021 season at home as Super Bowl champions.

Philadelphia Eagles at Atlanta Falcons

Date: Sunday, Sept. 12
Time: 1:00 p.m. ET
Spread: Falcons -3.5

Two first-year, first-time head coaches meet in Week 1 as Nick Sirianni and Arthur Smith lead the Eagles and Falcons, respectively into the first year of rebuilds.

Pittsburgh Steelers at Buffalo Bills

Date: Sunday, Sept. 12
Time: 1:00 p.m. ET
Spread: Bills -6.5

Ben Roethlisberger is back for an 18th season as the Steelers open on the road against a Bills team seeking their first Super Bowl appearance in 28 years.

Minnesota Vikings at Cincinnati Bengals

Date: Sunday, Sept. 12
Time: 1:00 p.m. ET
Spread: Vikings -3

All eyes will be on Joe Burrow as he returns from an ACL tear and two potential coaches on the NFL hot seat, Zac Taylor and Mike Zimmer.

[caption id="attachment_23640" align="aligncenter" width="1024"]Joe Burrow #9 of the Cincinnati Bengals participates in a drill during Mandatory Minicamp on June 15, 2021 in Cincinnati, Ohio. (Photo by Dylan Buell/Getty Images) (Photo by Dylan Buell/Getty Images)[/caption]

San Francisco 49ers at Detroit Lions

Date: Sunday, Sept. 12
Time: 1:00 p.m. ET
Spread: 49ers -7.5

Jared Goff was traded out of the NFC West but faces a familiar foe in his first start with the Detroit Lions.

Arizona Cardinals at Tennessee Titans

Date: Sunday, Sept. 12
Time: 1:00 p.m. ET
Spread: Titans -3

Kyler Murray, DeAndre Hopkins, Julio Jones, and Derrick Henry will be on the field in a season opener full of star power.

Seattle Seahawks at Indianapolis Colts

Date: Sunday, Sept. 12
Time: 1:00 p.m. ET
Spread: Colts -2.5

The Carson Wentz revival tour begins at home against Russell Wilson and the Seahawks.

Los Angeles Chargers at Washington Football Team

Date: Sunday, Sept. 12
Time: 1:00 p.m. ET
Spread: Chargers -1

Justin Herbert has a rookie head coach in Brandon Staley as he looks to build on the best rookie season from a quarterback in NFL history.

New York Jets at Carolina Panthers

Date: Sunday, Sept. 12
Time: 1:00 p.m. ET
Spread: Panthers -4.5

Sam Darnold faces his old team in his first start with the Carolina Panthers, who get Christian McCaffrey back from last year’s season-ending injury.

Jacksonville Jaguars at Houston Texans

Date: Sunday, Sept. 12
Time: 1:00 p.m. ET
Spread: Jaguars -2.5

The Houston Texans open the season with one of very few winnable games as they look to avoid a miserable season under first-year head coach David Culley.

Cleveland Browns at Kansas City Chiefs

Date: Sunday, Sept. 12
Time: 4:25 p.m. ET
Spread: Chiefs -6

In a rematch of last year’s Divisional Round, the Chiefs and Browns meet in a Week 1 blockbuster of Super Bowl contenders.

[caption id="attachment_23642" align="aligncenter" width="1024"]Chris Jones #95 of the Kansas City Chiefs pressures Baker Mayfield #6 of the Cleveland Browns in the fourth quarter of the AFC Divisional Playoff at Arrowhead Stadium on January 17, 2021 in Kansas City, Missouri. (Photo by David Eulitt/Getty Images) (Photo by David Eulitt/Getty Images)[/caption]

Miami Dolphins at New England Patriots

Date: Sunday, Sept. 12
Time: 4:25 p.m. ET
Spread: Patriots -2

Year two of the post-Brady era in New England begins against Tua Tagovailoa and a Dolphins’ team that missed last year’s playoffs despite 10 wins.

Green Bay Packers at New Orleans Saints

Date: Sunday, Sept. 12
Time: 4:25 p.m. ET
Spread: Saints -3

This will either be the Aaron Rodgers show after a tumultuous offseason or the first start of Jordan Love’s career.

Denver Broncos at New York Giants

Date: Sunday, Sept. 12
Time: 4:25 p.m. ET
Spread: Broncos -1

Daniel Jones has new offensive weapons for a critical third season as the Giants open against one of the league’s best defenses.

Chicago Bears at Los Angeles Rams

Date: Sunday, Sept. 12
Time: 8:20 p.m. ET
Spread: Rams -7

Will Justin Fields make an early NFL debut in Week 1 against the Rams?

Baltimore Ravens at Las Vegas Raiders

Date: Monday, Sept. 13
Time: 8:15 p.m. ET
Spread: Ravens -4.5

The Las Vegas Raiders will officially open their new billion-dollar home, Allegiant Stadium, in Week 1 against the Ravens.

How to Bet on Week 1 NFL Odds

Whether you’re a novice bettor browsing odds on mobile sports betting with the BetMGM Sportsbook app or a veteran breaking down numbers on your computer with online sports betting, betting on NFL odds Week 1 has never been easier.

From the BetMGM Sportsbook app, click the NFL logo on the top navigation bar:


From there, you can view all odds for Week 1 games, starting with the Cowboys-Bucs game on Thursday Night Football and ending with the Ravens-Raiders game on Monday Night Football. When you’re ready to place a wager, click one or multiple bets:

On your Bet Slip, you can adjust the wager amount, aka stake, for each bet by clicking a dollar amount or typing in a specific dollar amount. You can also combine any of your selections into a parlay by clicking “Parlay” at the top of the Bet Slip. And when your bets are ready, click Place Bet:

More NFL Odds

Week 1 is only one small piece of NFL betting opportunities at BetMGM.

Throughout the season, you can view updated NFL futures, Super Bowl odds, NFL win totals, and weekly NFL betting lines. You also have access to live NFL betting, a unique and exhilarating experience that allows you to take more control of your sports betting. Check out BetMGM’s live sports betting and get ready to bet online when the action starts.