Week 1 NFL Odds: How To Bet on Week 1 NFL Lines

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Cincinnati Bengals quarterback Joe Burrow (9) and Cincinnati Bengals wide receiver Ja'Marr Chase (1) celebrate during an NFL football game against the Baltimore Ravens, Sunday, Oct. 24, 2021 in Baltimore, Md. (AP Photo/Daniel Kucin Jr.)
(AP Photo/Daniel Kucin Jr.)
BetMGM @BETMGM May 21, 2023, 4:04 PM

The NFL is back in 2023 with an 18-game schedule and thousands of betting opportunities.

Whether you’re a Cincinnati Bengals fan betting on Joe Burrow and Ja’Marr Chase to cover the spread against Najee Harris and the Pittsburgh Steelers, a casual NFL fan building moneyline parlays with the Philadelphia Eagles, Kansas City Chiefs, and Green Bay Packers, or a longtime diehard betting on player props for Derrick Henry and Nick Chubb, there are NFL odds for everyone.

Here’s the spread, over/under total, and moneylines for each Week 1 game (as of May 21):

Week 1 NFL Schedule & Odds

Matchup & SpreadTotalMoneyline
Lions at Chiefs (-6.5)53.5DET +240, KC -300
Panthers at Falcons (-2.5)43.5CAR +130, ATL -155
Texans at Ravens (-9.5)44.5HOU +340, BAL -450
Bengals (-2.5) at Browns47.5CIN -140, CLE +115
Jaguars (-3.5) at Colts43.5JAC -190, IND +155
Bucs at Vikings (-6.5)45.5TB +225, MIN -275
Titans at Saints (-3.5)42.5TEN +155, NO -190
49ers (-3) at Steelers41.5SF -155, PIT +130
Cardinals at Commanders (-6)40.5ARI +195, WAS -250
Packers at Bears (-2.5)44.5GB +115, CHI -140
Eagles (-4.5) at Patriots46.5PHI -225, NE +180
Raiders at Broncos (-3.5)44.5LV +155, DEN -190
Dolphins at Chargers (-2.5)49.5MIA +115, LAC -140
Rams at Seahawks (-5.5)46.5LAR +200, SEA -250
Cowboys (-3) at Giants46.5DAL -155, NYG +130
Bills (-1.5) at Jets47.5BUF -120, NYJ +100

How to Bet on Week 1 NFL Odds

You can bet on Week 1 NFL odds with online sports betting from your computer or mobile sports betting from your phone with the BetMGM Sportsbook app.

  1. Click “NFL” on the top navigation bar.

2. Browse all odds for Week 1 games, starting with the Lions-Chiefs game on Thursday Night Football and ending with the Bills-Jets game on Monday Night Football. 

3. Add one or multiple wagers to your Bet Slip.

4. Add a wager amount, aka stake, for each bet, or combine your selections on a parlay by clicking “Parlay” at the top of the bet slip.

5. When you’re ready, click “Place Bet.”

6. Watch your bets in action on Thursday, Sunday, and Monday!

More NFL Odds

Week 1 is just the start of your NFL betting experience at BetMGM. Throughout the season, you can view updated NFL futures, including Super Bowl odds and NFL MVP odds, and weekly NFL betting lines. 

You also have access to live sports betting, a unique and exhilarating experience that allows you to place live bets during each preseason, regular-season, and postseason game.

Check out BetMGM’s live sports betting and get ready to bet online after kickoff.

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