Astros vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Sep 29

(AP Photo/Ryan Sun)
  • The Guardians are -160 favorites vs the Astros
  • Astros vs Guardians Over / Under today: 7.5 Runs
  • Astros / Guardians TV Channel: BSGL | SCHN

The Houston Astros (+135) visit Progressive Field to take on the Cleveland Guardians (-160) on Sunday, September 29, 2024. First pitch is scheduled for 3:10pm EDT in Cleveland, OH.

This season, the Astros are 88-73 against the spread (ATS), while the Guardians are 82-79 ATS.

Astros vs Guardians Starting Pitchers Today:

  • Astros starting pitcher: Ryan Gusto 0-0, 0.00 ERA
  • Guardians starting pitcher: Nick Sandlin 8-0, 3.69 ERA

Astros vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Astros+1.5 -160O 7.5 -110+135
Guardians -1.5 +135U 7.5 -110-160

Astros vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Sunday‘s MLB game with 60.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Astros players for Sunday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

  • Jeremy Pena has hit the Home Runs Over in 5 of his last 20 away games (+22.40 Units / 112% ROI)
  • Yainer Diaz has hit the RBIs Under in 15 of his last 17 games (+11.45 Units / 33% ROI)
  • Yainer Diaz has hit the Hits Over in 23 of his last 47 games (+9.90 Units / 17% ROI)
  • Yainer Diaz has hit the Runs Under in 11 of his last 12 away games (+9.65 Units / 48% ROI)
  • Alex Bregman has hit the Total Bases Over in 16 of his last 25 away games (+9.40 Units / 36% ROI)

And here are some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Lane Thomas has hit the Home Runs Over in 7 of his last 22 games (+22.60 Units / 103% ROI)
  • Andres Gimenez has hit the Hits Under in 24 of his last 44 games (+10.40 Units / 17% ROI)
  • Bo Naylor has hit the Runs Under in his last 10 games at home (+10.00 Units / 44% ROI)
  • Bo Naylor has hit the Hits Runs and RBIs Under in 9 of his last 10 games at home (+9.50 Units / 86% ROI)
  • Jose Ramirez has hit the RBIs Under in 22 of his last 29 games (+8.65 Units / 16% ROI)
  • The Houston Astros have hit the Game Total Under in 47 of their last 72 away games (+20.50 Units / 26% ROI)
  • The Houston Astros have covered the Run Line in 58 of their last 103 games (+15.15 Units / 12% ROI)
  • The Houston Astros have covered the 1st Five Innings (F5) Run Line in 19 of their last 26 away games (+11.40 Units / 37% ROI)
  • The Houston Astros have hit the Moneyline in 55 of their last 88 games (+11.40 Units / 9% ROI)
  • The Houston Astros have hit the Team Total Over in 71 of their last 125 games (+10.25 Units / 7% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 43 of their last 69 games (+18.70 Units / 25% ROI)
  • The Cleveland Guardians have covered the Run Line in 38 of their last 76 games at home (+11.30 Units / 13% ROI)
  • The Cleveland Guardians have hit the Moneyline in 92 of their last 161 games (+10.70 Units / 5% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 11 of their last 14 games (+7.60 Units / 40% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 3 of their last 5 games (+1.05 Units / 18% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 81-80 against the Run Line (+2.4 Units / 1.21% ROI).

  • 88-73 when betting on the Moneyline for -8.6 Units / -3.64% ROI
  • 65-91 when betting on the total runs Over for -34.45 Units / -19.57% ROI
  • 91-65 when betting on the total runs Under for +19 Units / 10.65% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 82-79 against the Run Line (+5.9 Units / 2.92% ROI).

  • 92-69 when betting on the Moneyline for +10.7 Units / 5.11% ROI
  • 69-82 when betting on the total runs Over for -21.45 Units / -12.08% ROI
  • 82-69 when betting on the total runs Under for +6.05 Units / 3.42% ROI

Guardians vs Astros Home Run Prop Bets Today

Over Under
Kyle Tucker (HOU) 0.5 +400 0.5 -550
Jose Ramirez (CLE) 0.5 +450 0.5 -650
Kyle Manzardo (CLE) 0.5 +500 0.5 -700
Alex Bregman (HOU) 0.5 +525 0.5 -750
Josh Naylor (CLE) 0.5 +550 0.5 -800

Guardians vs Astros Total Hits Prop Bets Today

Over Under
Steven Kwan (CLE) 0.5 -275 0.5 +195
Jose Ramirez (CLE) 0.5 -250 0.5 +180
Kyle Tucker (HOU) 0.5 -225 0.5 +165
Andres Gimenez (CLE) 0.5 -225 0.5 +165
Jose Altuve (HOU) 0.5 -225 0.5 +165

Guardians vs Astros RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +140 0.5 -190
Josh Naylor (CLE) 0.5 +145 0.5 -190
Alex Bregman (HOU) 0.5 +145 0.5 -190
Yainer Diaz (HOU) 0.5 +160 0.5 -210
Kyle Tucker (HOU) 0.5 +165 0.5 -225

Guardians vs Astros Strikeout Prop Bets Today

Over Under
Nick Sandlin (CLE) 1.5 +170 1.5 -225

No Matchup notes for this Game

Guardians Starting Pitcher Stats & Trends

Right-handed hitters have a line drive rate of just 15% (37/249) against Nick Sandlin since the 2022 season — 2nd lowest among qualified RPs in MLB; League Avg: 23% — 99th Percentile.

Nick Sandlin has a strike rate of just 59% (347/589) against right-handed batters this season — 2nd lowest among qualified RPs in MLB; League Avg: 65% — second Percentile.

Nick Sandlin has walked 20 of 143 right-handed batters (14%) this season — 2nd highest among AL Relievers; League Avg: 8% — second Percentile.

Opponents have a line drive rate of just 12% (26/211) against Nick Sandlin on non-fastballs since the 2022 season — lowest among qualified RPs in MLB; League Avg: 22% — 100th Percentile.

Astros Keys to the Game vs. the Guardians

The Astros are just 0-55 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .050.

The Astros are just 5-13 (.278) when tied entering the 8th inning this season — 3rd lowest in MLB; League Avg: .500.

The Astros are just 4-10 (.286) after a loss as underdogs this season — 2nd lowest in MLB; League Avg: .434.

The Astros are 81-58 (.583) after a road win since the 2022 season — best in MLB; League Avg: .483.

Guardians Keys to the Game vs. the Astros

The Guardians are 70-2 (.972) when leading entering the 7th inning this season — best in MLB; League Avg: .856.

The Guardians are 30-15 (.667) after a home win this season — tied for best in MLB; League Avg: .519.

The Guardians are 81-0 (1.000) when leading entering the 9th inning this season — best in MLB; League Avg: .950.

The Guardians are just 3-59 (.048) when trailing entering the 8th inning this season — 3rd lowest in MLB; League Avg: .100.

Astros hitters have just 972 strikeouts in 5,329 PA’s (18%) against LHP since the 2022 season — best in MLB; League Avg: 23%.

The Astros are batting .267 against LHP since the 2022 season — 2nd best in MLB; League Avg: .248.

Astros hitters are averaging just 3.65 pitches per plate appearance against RHP this season — lowest in MLB; League Avg: 3.89.

Astros hitters have an OPS of .850 (925 PA’s) in lefty-lefty matchups since last season — best in MLB; League Avg: .680.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — lowest in MLB; League Avg: 38%.

Guardians hitters have put just 35% of balls in play to the left side of the field since the 2022 season — lowest in MLB; League Avg: 38%.

Guardians hitters had a Hard-Hit Rate of just 33% in the 2023 season — lowest in MLB; League Avg: 40%.

Guardians hitters have a swing rate of 64% with two-strikes since the 2022 season — highest in MLB; League Avg: 60%.

The average home run distance against the Astros pitchers this season is 388.2 feet — best in MLB; League Avg: 397.5

Astros pitchers have an ERA of 3.51 (2115.1 IP) on the road since the 2022 season — best in MLB; League Avg: 4.25.

Astros pitchers have a strikeout rate of 25% since the 2022 season — 2nd best in MLB; League Avg: 23%.

Opponents have a miss rate of 28% against Astros pitchers since the 2022 season — 2nd best in MLB; League Avg: 26%.

Opponents have a groundball batting average of just .207 against Guardians pitchers with runners on base this season — best in MLB; League Avg: .262.

Opponents have a groundball batting average of just .223 against Guardians pitchers this season — best in MLB; League Avg: .249.

Guardians pitchers have won 40% of games in which they have allowed their opponent to score in three different innings this season — highest in MLB; League Avg: 26%.

The Guardians have allowed 0.87 runs per game (140/161) in late innings this season — best in MLB; League Avg: 1.29.

Guardians vs. Astros Injuries Tonight That May Affect Prop Bets 

  • Cleveland Guardians – No Injuries Reported
  • Houston Astros – No Injuries Reported

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About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.