Padres vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Jul 21

Cleveland Guardians' Josh Naylor runs the base path during a spring training baseball game against the San Diego Padres, Monday, Feb. 26, 2024, in Peoria, Ariz.
(AP Photo/Lindsey Wasson)
  • The Guardians are -120 favorites vs the Padres
  • Padres vs Guardians Over / Under today: 8 Runs
  • Padres / Guardians TV Channel: BSGL | PDTV | ESPN+

The San Diego Padres (+100) visit Progressive Field to take on the Cleveland Guardians (-120) on Sunday, July 21, 2024. First pitch is scheduled for 1:40pm EDT in Cleveland, OH.

This season, the Padres are 51-50 against the spread (ATS), while the Guardians are 49-48 ATS.

Padres vs Guardians Starting Pitchers Today:

  • Padres starting pitcher: Michael King 7-6, 3.43 ERA
  • Guardians starting pitcher: Ben Lively 8-5, 3.60 ERA

Padres vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Padres+1.5 -210O 8 -110+100
Guardians -1.5 +160U 8 -110-120

Padres vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Sunday‘s MLB game with 54.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Padres vs Guardians and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Padres players for Sunday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

  • Jackson Merrill has hit the Home Runs Over in 6 of his last 14 games (+37.30 Units / 266% ROI)
  • Jackson Merrill has hit the RBIs Over in 11 of his last 18 games (+13.55 Units / 75% ROI)
  • Jurickson Profar has hit the Hits Over in 20 of his last 24 away games (+11.50 Units / 22% ROI)
  • Jurickson Profar has hit the Singles Over in 18 of his last 24 away games (+11.05 Units / 39% ROI)
  • Jurickson Profar has hit the Hits Runs and RBIs Over in 14 of his last 17 games (+10.80 Units / 55% ROI)

And here are some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Steven Kwan has hit the Home Runs Over in 4 of his last 16 games (+37.00 Units / 231% ROI)
  • Jose Ramirez has hit the Runs Over in 32 of his last 44 games (+19.65 Units / 40% ROI)
  • Jose Ramirez has hit the RBIs Over in 26 of his last 43 games (+15.45 Units / 35% ROI)
  • Steven Kwan has hit the Hits Runs and RBIs Over in 16 of his last 18 games (+13.30 Units / 50% ROI)
  • Andres Gimenez has hit the Hits Under in 11 of his last 18 games (+11.40 Units / 55% ROI)
  • The San Diego Padres have covered the Run Line in 30 of their last 47 away games (+13.10 Units / 21% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 13 of their last 18 away games (+8.80 Units / 45% ROI)
  • The San Diego Padres have hit the Game Total Under in 13 of their last 18 away games (+7.35 Units / 37% ROI)
  • The San Diego Padres have hit the Moneyline in 6 of their last 9 away games (+4.25 Units / 45% ROI)
  • The Cleveland Guardians have hit the Moneyline in 29 of their last 38 games at home (+14.80 Units / 27% ROI)
  • The Cleveland Guardians have hit the Team Total Over in 26 of their last 38 games at home (+13.10 Units / 30% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 57 of their last 97 games (+12.70 Units / 11% ROI)
  • The Cleveland Guardians have covered the Run Line in 21 of their last 39 games at home (+11.25 Units / 27% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 24 of their last 38 games at home (+10.05 Units / 23% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 50-51 against the Run Line (+0.25 Units / 0.2% ROI).

  • 51-50 when betting on the Moneyline for -8.55 Units / -6.56% ROI
  • 53-47 when betting on the total runs Over for +1.7 Units / 1.54% ROI
  • 47-53 when betting on the total runs Under for -11.7 Units / -10.44% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 49-48 against the Run Line (+4.55 Units / 3.87% ROI).

  • 59-38 when betting on the Moneyline for +13.77 Units / 10.81% ROI
  • 47-44 when betting on the total runs Over for -1.65 Units / -1.54% ROI
  • 44-47 when betting on the total runs Under for -7.55 Units / -7.12% ROI

Guardians vs Padres Home Run Prop Bets Today

Over Under
Manny Machado (SD) 0.5 +475 0.5 -650
Josh Naylor (CLE) 0.5 +500 0.5 -750
Jose Ramirez (CLE) 0.5 +525 0.5 -750
Jake Cronenworth (SD) 0.5 +600 0.5 -900
Kyle Higashioka (SD) 0.5 +625 0.5 -1000

Guardians vs Padres Total Hits Prop Bets Today

Over Under
Manny Machado (SD) 0.5 -275 0.5 +195
Josh Naylor (CLE) 0.5 -250 0.5 +175
Jose Ramirez (CLE) 0.5 -250 0.5 +175
Xander Bogaerts (SD) 0.5 -250 0.5 +185
Jurickson Profar (SD) 0.5 -225 0.5 +160

Guardians vs Padres RBI Prop Bets Today

Over Under
Manny Machado (SD) 0.5 +135 0.5 -175
Josh Naylor (CLE) 0.5 +145 0.5 -190
Jose Ramirez (CLE) 0.5 +150 0.5 -200
Jake Cronenworth (SD) 0.5 +160 0.5 -210
David Peralta (SD) 0.5 +165 0.5 -225

Guardians vs Padres Strikeout Prop Bets Today

Over Under
Ben Lively (CLE) 3.5 -110 3.5 -120

Michael King has allowed an average Exit Velocity of just 82.3 MPH on non-fastballs since the 2022 season (282 balls in play) — best in MLB among starting pitchers with at least 163 total IP; League Avg: 87.1

Michael King has a strikeout rate of 33% (60 SO in 180 PAs) when going through the lineup the first time in a game this season — tied for 4th best among qualified SPs in MLB; League Avg: 25% — 95th Percentile.

Michael King has struck out 32% (73/226) of right-handed batters he faced this season — 4th best among qualified SPs in MLB; League Avg: 24% — 95th Percentile.

Michael King has allowed an average Exit Velocity of just 86.3 MPH since the 2022 season (606 balls in play) — tied for 4th best in MLB among starting pitchers with at least 163 total IP; League Avg: 88.9

Guardians Starting Pitcher Stats & Trends

Opponents are hitting just .059 (1-for-17) against Ben Lively when going through the lineup the first time in a game in his last two starts — tied for 4th best in MLB over the last two weeks; League Avg: .229 — 96th Percentile.

Ben Lively has allowed a slugging percentage of .630 (92 Total Bases / 146 ABs) on inside fastballs since the 2022 season — 3rd highest in MLB among starting pitchers with at least 168 total IP; League Avg: .430 — second Percentile.

Ben Lively has allowed a slugging percentage of .630 (92 Total Bases / 146 ABs) on inside fastballs since last season — 3rd highest in MLB among starting pitchers with at least 103 total IP; League Avg: .434 — second Percentile.

Opponents have a line drive rate of just 8% (4/48) against Ben Lively this month (3 games) — lowest among qualified SPs in MLB; League Avg: 24% — 100th Percentile.

Padres Keys to the Game vs. the Guardians

The Padres are just 32-112 (.222) when scoring 4 or fewer runs since the 2023 season — 5th lowest in MLB; League Avg: .270.

The Padres are just 0-45 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .056.

The Padres are just 12-45 (.211) when scoring 4 or fewer runs this season — 5th lowest in MLB; League Avg: .275.

The Padres are just 10-163 (.058) when trailing entering the 8th inning since the 2022 season — 4th lowest in MLB; League Avg: .095.

Guardians Keys to the Game vs. the Padres

The Guardians are 31-11 (.738) at home this season — best in MLB; League Avg: .531.

The Guardians are 18-14 (.562) when allowing 2 or more home runs this season — best in MLB; League Avg: .301.

The Guardians are 13-3 (.812) after a home loss this season — 2nd best in MLB; League Avg: .547.

The Guardians are 10-14 (.417) when allowing 10 or more hits this season — 2nd best in MLB; League Avg: .245.

The Padres are batting .316 when facing the starting pitcher for the 3rd time in a game this season — best in MLB; League Avg: .265.

Padres hitters have an OBP of .378 (459 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB; League Avg: .329.

The Padres are batting .275 on the road this season — best in MLB; League Avg: .241.

Padres hitters have just 945 strikeouts in 4,689 PA’s (20%) against LHP since the 2022 season — 5th best in MLB; League Avg: 22%.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — lowest in MLB; League Avg: 38%.

Guardians hitters have just 2,070 strikeouts in 11,326 PA’s (18%) against RHP since the 2022 season — best in MLB; League Avg: 23%.

Guardians hitters have missed on just 22% of swings since the 2022 season — best in MLB; League Avg: 26%.

Guardians hitters have put 41% of balls in play to the right side of the field since last season — highest in MLB; League Avg: 37%.

Padres pitchers allowed an average Exit Velocity of 87.9 MPH (3,921 batted balls) in the 2023 season — best in MLB; League Avg: 89.0.

The Padres pitchers allowed an average Exit Velocity of just 87.9 MPH in the 2023 season (3,921 balls in play) — best in MLB; League Avg: 89.0

Padres pitchers have a strikeout rate of 24% this season — 5th best in MLB; League Avg: 22%.

Opponents have a groundball rate of just 35% against Padres pitchers over the last 14 days — lowest in MLB; League Avg: 44%.

Opponents have a groundball batting average of just .198 against Guardians pitchers with runners on base this season — best in MLB; League Avg: .259.

Guardians pitchers have won 47% of games in which they have allowed their opponent to score in three different innings this season — highest in MLB; League Avg: 26%.

Guardians pitchers have a strikeout rate of 44% with two-strikes this season — 2nd best in MLB; League Avg: 42%.

The Guardians have allowed 0.75 runs per game (73/97) in late innings this season — best in MLB; League Avg: 1.28.

Guardians vs. Padres Injuries Tonight That May Affect Prop Bets 

  • Daniel Espino (Cleveland Guardians): Shoulder, Out
  • Gavin Williams (Cleveland Guardians): Elbow, 15-Day IL
  • Ben Lively (Cleveland Guardians): Illness, 15-Day IL
  • Luis Ortiz (Cleveland Guardians): Ankle, 15-Day IL
  • Xzavion Curry (Cleveland Guardians): Illness, 15-Day IL
  • Joey Cantillo (Cleveland Guardians): Hamstring, Out
  • Angel Martinez (Cleveland Guardians): Foot, 10-Day IL
  • Sam Hentges (Cleveland Guardians): Finger, 15-Day IL
  • Trevor Stephan (Cleveland Guardians): Elbow, 60-Day IL
  • George Valera (Cleveland Guardians): Hamstring, Out
  • James Karinchak (Cleveland Guardians): Shoulder, 60-Day IL
  • Glenn Otto (San Diego Padres): Shoulder, 15-Day IL
  • Reiss Knehr (San Diego Padres): Elbow, Out
  • Drew Carlton (San Diego Padres): Elbow, Out
  • Luis Patino (San Diego Padres): Elbow, 15-Day IL
  • Tucupita Marcano (San Diego Padres): Knee, 10-Day IL

Bet now on Padres vs Guardians and all games with BetMGM


Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.

First Bet Offer BetMGM State Promo Pages $1,500
About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.