DePaul vs Northwestern Prediction, Odds & Best Bets Today – NCAAB, Dec. 21

Northwestern head coach Chris Collins coaches against Rutgers during the second half of an NCAA college basketball game, Sunday, March 5, 2023 in Piscataway, N.J. Northwestern won 65-53. (AP Photo/Noah K. Murray)
(AP Photo/Noah K. Murray)
  • Northwestern is a -6.5 point favorite vs DePaul
  • Total (Over/Under): 136.5 points
  • DePaul / Northwestern TV channel: BTN

The DePaul Blue Demons visit Welsh-Ryan Arena to take on the Northwestern Wildcats on Dec. 21. Tip off is scheduled for 4:00pm EST in Evanston, IL.

Northwestern is the betting favorite in this game, with the spread sitting at -6.5 (-110).

The DePaul vs. Northwestern Over/Under is 136.5 total points.

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DePaul vs. Northwestern Odds, Spread, Over/Under

SpreadTotal (O/U)Moneyline
DePaul+6.5 -110O 136.5 -110+230
Northwestern -6.5 -110U 136.5 -110-275

DePaul vs Northwestern Prediction for Today:

The winning team model predicts Northwestern will win this college basketball game with 79.6% confidence, based on game simulations, player injuries, key player performances and recent matchups.

DePaul vs Northwestern Spread Prediction:

Based on recent against-the-spread trends, the spread model predicts Northwestern will cover the spread with 56.2% confidence for today’s game.


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  • DePaul has hit the 1H Game Total Under in 9 of their last 13 away games (+4.40 Units / 30% ROI)
  • DePaul have covered the 1H Spread in 9 of their last 13 away games (+4.30 Units / 29% ROI)
  • DePaul has hit the Game Total Over in 18 of their last 33 games (+1.45 Units / 4% ROI)
  • Northwestern has hit the Moneyline in 16 of their last 18 games at home (+14.85 Units / 10% ROI)
  • Northwestern has hit the 1H Moneyline in 15 of their last 18 games at home (+7.35 Units / 9% ROI)
  • Northwestern has hit the 1H Game Total Under in 19 of their last 34 games (+1.85 Units / 5% ROI)
  • Northwestern has hit the Game Total Over in 18 of their last 34 games (+1.45 Units / 4% ROI)
  • Northwestern has hit the Team Total Over in 10 of their last 18 games at home (+0.75 Units / 4% ROI)

DePaul Basketball Against the Spread Record (ATS)

DePaul has a 6-5 record against the spread this college basketball season (+0.5 Units / 4.13% ROI).

  • 8-3 when betting on the Moneyline for +4.65 Units / 5.56% ROI
  • 6-5 when betting the Over for +0.45 Units / 3.7% ROI
  • 5-6 when betting the Under for -1.6 Units / -13.28% ROI

Northwestern Basketball Against the Spread Record (ATS)

Northwestern has a 4-7 record against the spread this college basketball season (-3.7 Units / -30.58% ROI).

  • 7-4 when betting on the Moneyline for +1.95 Units / 1.79% ROI
  • 5-6 when betting the Over for -1.6 Units / -13.22% ROI
  • 6-5 when betting the Under for +0.5 Units / 4.13% ROI

DePaul Offensive Stats & Trends:

DePaul has made 12.2 three-pointers per game this season — best among Power Conference teams; League Avg: 8.4

DePaul averaged 64.4 points per game (1,933 points/30 games) last season — 9th lowest among Division 1 Teams; League Avg: 73.6

DePaul averaged 14.0 turnovers per game (420 turnovers/30 games) last season — 13th highest among Division 1 Teams; League Avg: 11.6

DePaul averaged 7.5 offensive rebounds per game (224 rebounds/30 games) last season — lowest among Power Conference teams; League Avg: 10.8

Northwestern Offensive Stats & Trends:

Northwestern has averaged 7.7 turnovers per game (199 turnovers/26 games) at home since the start of the 2023-24 season — best among Big 10 Teams; League Avg: 10.8

Northwestern has averaged 9.1 turnovers per game (392 turnovers/43 games) since the start of the 2023-24 season — tied for best among Power Conference teams; League Avg: 11.3

Northwestern has an assist to turnover ratio of 1.7 (657 assists/ 392 TOs) since the start of the 2023-24 season — tied for 5th best among Division 1 Teams; League Avg: 1.2

Northwestern has averaged 1.22 points per shot (801 points/656 shots) this season — lowest among Big 10 Teams; League Avg: 1.35

DePaul Defensive Stats & Trends:

DePaul allowed 10.5 made three-pointers per game last season — highest among Power Conference defenses; League Avg: 7.7

DePaul averaged 22.5 defensive rebounds per game (676 rebounds/30 games) last season — 3rd lowest among Power Conference teams; League Avg: 25.7

DePaul has allowed 9.9 made three-pointers per game since the start of the 2023-24 season — highest among Power Conference defenses; League Avg: 7.9

DePaul allowed opponents to shoot 50% (739/1,467) last season — 2nd highest among Power Conference defenses; League Avg: 45%

Northwestern Defensive Stats & Trends:

Northwestern has averaged 23.7 defensive rebounds per game (1,021 rebounds/43 games) since the start of the 2023-24 season — tied for 5th lowest among Power Conference teams; League Avg: 25.9

Northwestern averaged 23.0 defensive rebounds per game (736 rebounds/32 games) last season — 5th lowest among Power Conference teams; League Avg: 25.7

Northwestern has allowed opponents to shoot 30% from three (99/334) on the road since the start of the 2023-24 season — best among Big 10 Teams; League Avg: 35%

Northwestern stole the ball 229 times last season — 3rd most among Big 10 Teams


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.