Duke vs Middle Tenn State Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 4

Middle Tennessee quarterback Nicholas Vattiato (11) throws a pass against Murray State during the first half of an NCAA college football game Saturday, Sept. 16, 2023, in Murfreesboro, Tenn. (AP Photo/George Walker IV)
(AP Photo/George Walker IV)
  • Duke is a -14.5 point favorite vs. Middle Tenn State
  • Duke vs. Middle Tennessee Total(Over/Under): 51.5 points
  • TV Channel: ESPNU

The Duke Blue Devils (3-0) visit Johnny (Red) Floyd Stadium to take on the Middle Tennessee Blue Raiders (1-2) on Sep. 21 in Murfreesboro, TN. Kickoff is scheduled for 4:00pm EDT.

Duke is a betting favorite in Week 4, with the spread sitting at -14.5 (-110).

The Duke vs. Middle Tennessee Over/Under is 51.5 total points.

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Duke vs. Middle Tennessee Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Duke-14.5 -11051.5 -105-650
Middle Tennessee +14.5 -11051.5 -115+450

Duke vs Middle Tennessee Prediction:

The winning team model predicts Duke will win this game with 84.2% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Duke and Middle Tenn State, key player performances this season and recent team trends.

Duke vs Middle Tennessee Spread Prediction:

Based on recent against-the-spread trends, the model predicts Middle Tennessee will cover the spread with 77.7% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Duke has hit the 1H Moneyline in 5 of their last 12 games (+4.05 Units / 14% ROI)
  • Duke has hit the Game Total Over in 5 of their last 6 away games (+3.90 Units / 59% ROI)
  • Duke has hit the Moneyline in 7 of their last 12 games (+2.80 Units / 7% ROI)
  • Duke has hit the 1H Game Total Under in 7 of their last 13 games (+2.65 Units / 19% ROI)
  • Duke has hit the 1Q Game Total Under in 8 of their last 12 games (+2.55 Units / 17% ROI)
  • Middle Tennessee has hit the Game Total Over in 6 of their last 7 games at home (+4.90 Units / 64% ROI)
  • Middle Tennessee has hit the 1Q Game Total Over in 8 of their last 11 games (+4.85 Units / 39% ROI)
  • Middle Tennessee has hit the 1H Moneyline in 5 of their last 6 games at home (+4.00 Units / 37% ROI)
  • Middle Tennessee has hit the 1Q Moneyline in 4 of their last 6 games at home (+3.00 Units / 30% ROI)
  • Middle Tennessee have covered the 1H Spread in 5 of their last 7 games at home (+2.70 Units / 34% ROI)

We’ve highlighted some favorite college football player prop bets for Duke players, looking at profitable historical betting trends:

Best Duke Player Prop Bets Today

  • Jordan Moore has hit the Receiving Yards Under in his last 3 games (+3.00 Units / 82% ROI)
  • Jaquez Moore has hit the Rushing Yards Over in his last 2 games (+2.00 Units / 83% ROI)
  • Grayson Loftis has hit the Passing Yards Under in his last game (+1.00 Units / 83% ROI)
  • Grayson Loftis has hit the TD Passes Under in his last game (+1.00 Units / 50% ROI)

Top NCAAF player prop bets for Middle Tennessee players, looking at profitable historical betting trends:

Best Middle Tennessee Player Prop Best Bets Today

  • Nicholas Vattiato has hit the TD Passes Over in his last game (+1.15 Units / 115% ROI)
  • Holden Willis has hit the Receiving Yards Over in his last game (+1.00 Units / 83% ROI)
  • Nicholas Vattiato has hit the Passing Yards Over in his last game (+1.00 Units / 83% ROI)

Duke Against the Spread (ATS) Record

Duke is 1-2 against the spread this college football season (-1.2 Units / -36.36% ROI).

  • Duke is 2-0 when betting on the Moneyline for +2.15 Units / 22.63% ROI
  • Duke is 1-2 when betting the Over for -1.2 Units / -35.82% ROI
  • Duke is 2-1 when betting the Under for +0.95 Units / 29.23% ROI

Middle Tennessee Against the Spread (ATS) Record

Middle Tenn State is 0-3 against the spread this college football season (-3.25 Units / -100% ROI).

  • Middle Tennessee is 0-1 when betting on the Moneyline for -1 Units / -100% ROI
  • Middle Tennessee is 2-1 when betting the Over for +0.9 Units / 27.27% ROI
  • Middle Tennessee is 1-2 when betting the Under for -1.2 Units / -36.36% ROI

Duke: Keys to the Game vs. Middle Tennessee

Duke is 5-2 (.625) when averaging more than 5 yards on first down plays since the 2023 season– T-30th-best in FBS; Average: .495

Duke is 8-5 (.615) when the opposing team rushes more than 30 times since the 2023 season– T-26th-best in FBS; Average: .407

Duke is 8-4 (.571) when passing for more than 200 yards since the 2022 season– T-34th-best in FBS; Average: .486

Duke is 9-3 (.643) when allowing less than 3 sacks since the 2023 season– 36th-best in FBS; Average: .524

Middle Tennessee: Keys to the Game vs. Duke

Middle Tennessee is winless (0-7) when allowing 120 or more rushing yards since the 2023 season– T-worst in FBS; Average: .355

Middle Tennessee is winless (0-8) when allowing 100 or more rushing yards since the 2023 season– T-worst in FBS; Average: .391

Middle Tennessee is winless (0-10) when allowing 120 or more rushing yards since the 2022 season– T-worst in FBS; Average: .358

Middle Tennessee is 2-8 (.200) when allowing an average of more than 5 yards on first down plays since the 2023 season– T-27th-worst in FBS; Average: .426

Matchup Notes for Duke vs. Middle Tennessee

Middle Tennessee’s offense has thrown for 917 passing yards in 3 games (305.7 YPG) this season — 21st-best among FBS offenses. Duke’s defense has allowed just 134.3 passing yards per game this season — 21st-best among FBS defenses.

Middle Tennessee’s WRs has gained 633 yards on 39 receptions (16.2 YPR) this season — T-21st-best among FBS WRs. Duke’s defense has allowed just 7.9 Yards Per Reception this season — T-8th-best among FBS defenses.

Middle Tennessee’s QBs has thrown for 917 passing yards in 3 games (305.7 YPG) this season — 19th-best among FBS teams. Duke’s defense has allowed just 134.3 passing yards per game this season — 4th-best among ACC defenses.

Duke’s TEs has 7 receptions in 3 games (just 2.3 per game) this season — T-2nd-worst among ACC TEs. Middle Tennessee’s defense has allowed 29.0 receptions per game this season — worst among NonP5 defenses.

Duke’s offense has thrown for 3,166 passing yards in 16 games (just 197.9 YPG) since the 2023 season — 30th-worst among FBS offenses. Middle Tennessee’s defense has allowed 276.4 passing yards per game since the 2023 season — 6th-worst among FBS defenses.

Duke’s TEs has 7 receptions in 3 games (just 2.3 per game) this season — T-2nd-worst among ACC TEs. Middle Tennessee’s defense has allowed 29.0 receptions per game this season — worst among FBS defenses.

Duke Offensive Stats & Trends

Duke TEs have averaged just 1.0 yards per reception (1 yards/1 catches) on 3rd and long since the 2022 season– worst among Power Conference Teams; Average: 12.2

Duke’s TEs has 7 receptions in 3 games (just 2.3 per game) this season — T-2nd-worst among ACC TEs. Middle Tennessee’s defense has allowed 29.0 receptions per game this season — worst among NonP5 defenses.

Duke’s offense has thrown for 3,166 passing yards in 16 games (just 197.9 YPG) since the 2023 season — 30th-worst among FBS offenses. Middle Tennessee’s defense has allowed 276.4 passing yards per game since the 2023 season — 6th-worst among FBS defenses.

Duke WRs have been targeted 23 times with 4-6 yards to go this season– most among Power Conference Teams

Duke’s TEs has 7 receptions in 3 games (just 2.3 per game) this season — T-2nd-worst among ACC TEs. Middle Tennessee’s defense has allowed 29.0 receptions per game this season — worst among FBS defenses.

Middle Tennessee Offensive Stats & Trends

Middle Tennessee’s offense has thrown for 917 passing yards in 3 games (305.7 YPG) this season — 21st-best among FBS offenses. Duke’s defense has allowed just 134.3 passing yards per game this season — 21st-best among FBS defenses.

Middle Tennessee’s WRs has gained 633 yards on 39 receptions (16.2 YPR) this season — T-21st-best among FBS WRs. Duke’s defense has allowed just 7.9 Yards Per Reception this season — T-8th-best among FBS defenses.

Middle Tennessee’s QBs has thrown for 917 passing yards in 3 games (305.7 YPG) this season — 19th-best among FBS teams. Duke’s defense has allowed just 134.3 passing yards per game this season — 4th-best among ACC defenses.

Middle Tennessee’s QBs has thrown for 917 passing yards in 3 games (305.7 YPG) this season — 19th-best among FBS teams. Duke’s defense has allowed just 134.3 passing yards per game this season — 21st-best among FBS defenses.

Middle Tennessee’s WRs has gained 633 yards on 39 receptions (16.2 YPR) this season — T-21st-best among FBS WRs. Duke’s defense has allowed just 7.1 Yards Per Reception to WRs this season — best among FBS defenses.

Duke Blue Devils Defensive Stats & Trends

Duke opponents has averaged 42.2 Passing Attempts per TD (507 Pass Attempts/12 Passing TDs) since the 2023 season– 4th-best in FBS; Average: 20.7

Duke has tackled opponents for a loss on 33 of 110 rushing attempts (30% TFL%) this season– 2nd-best in FBS; Average: 16%.

Duke has allowed 12 touchdowns on 311 completions (25.9 Completions Per TD) since the 2023 season– 2nd-best in FBS; Average: 12.5

Duke has tackled opponents for a loss on 33 of 110 rushing attempts (30% TFL%) this season– 2nd-best among Power Conference Teams; Average: 18%.

Duke has allowed just 10.1 yards per completion (3,143 yards/311 completions) since the 2023 season– T-4th-best in FBS; Average: 11.8

Middle Tennessee Blue Raiders Defensive Stats & Trends

Middle Tennessee has allowed 7 TD passes in the Red Zone this season– T-most in FBS

Middle Tennessee has allowed 6 first down receptions in the Red Zone this season– 2nd-most in FBS

Middle Tennessee has allowed 14 TDs in the Red Zone this season– most in FBS

Middle Tennessee has allowed 384.0 Passing Yards per game (1,152/3) this season– worst in FBS; Average: 204.0

Middle Tennessee has allowed 7 TD passes in the Red Zone this season– T-most among Non-Power Conference Teams


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About the Author

Nick Hennion

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Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.