Astros vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Apr 15

St. Louis Cardinals second baseman Nolan Gorman throws out Cincinnati Reds' Elly De La Cruz at first base during the fifth inning of a baseball game, Friday, Sept. 8, 2023, in Cincinnati. (AP Photo/Joshua A. Bickel)
(AP Photo/Joshua A. Bickel)
  • The Astros are -135 favorites vs the Cardinals
  • Astros vs Cardinals Over / Under today: 7.5 Runs
  • Astros / Cardinals TV Channel: SCHN | FDMX

The Houston Astros (-130) visit Busch Stadium to take on the St. Louis Cardinals (+110) on Tuesday, April 15, 2025. First pitch is scheduled for 7:45pm EDT in St. Louis, MO.

This season, the Astros are 0-0 against the spread (ATS), while the Cardinals are 0-0 ATS.

Astros vs Cardinals Starting Pitchers Today:

  • Astros starting pitcher: Hunter Brown 1-1, 1.97 ERA
  • Cardinals starting pitcher: Erick Fedde 1-1, 4.40 ERA

Astros vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Astros-1.5 +140O 7.5 -118-130
Cardinals +1.5 -170U 7.5 -102+110

Astros vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Tuesday‘s MLB game with 53.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Astros players for Tuesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

And here are some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • The Houston Astros have hit the Game Total Under in 85 of their last 146 games (+21.85 Units / 14% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 30 of their last 51 games (+16.20 Units / 20% ROI)
  • The Houston Astros have covered the 1st Five Innings (F5) Run Line in 73 of their last 124 games (+14.95 Units / 10% ROI)
  • The Houston Astros have covered the Run Line in 58 of their last 105 games (+13.15 Units / 10% ROI)
  • The Houston Astros have hit the Moneyline in 28 of their last 45 away games (+9.20 Units / 17% ROI)
  • The St. Louis Cardinals have covered the Run Line in 26 of their last 41 games (+9.15 Units / 16% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 18 of their last 27 games at home (+9.10 Units / 31% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 22 of their last 37 games (+8.90 Units / 21% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 21 games at home (+7.35 Units / 30% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 0-0 against the Run Line (+0 Units / 0% ROI).

  • 0-0 when betting on the Moneyline for +0 Units / 0% ROI
  • 0-0 when betting on the total runs Over for +0 Units / 0% ROI
  • 0-0 when betting on the total runs Under for +0 Units / 0% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 0-0 against the Run Line (+0 Units / 0% ROI).

  • 0-0 when betting on the Moneyline for +0 Units / 0% ROI
  • 0-0 when betting on the total runs Over for +0 Units / 0% ROI
  • 0-0 when betting on the total runs Under for +0 Units / 0% ROI

Cardinals vs Astros Home Run Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +360 0.5 -500
Christian Walker (HOU) 0.5 +475 0.5 -650
Nolan Gorman (STL) 0.5 +625 0.5 -1000
Yainer Diaz (HOU) 0.5 +725 0.5 -1200
Isaac Paredes (HOU) 0.5 +725 0.5 -1200

Cardinals vs Astros Total Hits Prop Bets Today

Over Under
Yainer Diaz (HOU) 0.5 -275 0.5 +195
Jose Altuve (HOU) 0.5 -250 0.5 +185
Jeremy Pena (HOU) 0.5 -225 0.5 +170
Yordan Alvarez (HOU) 0.5 -210 0.5 +160
Brendan Donovan (STL) 0.5 -200 0.5 +155

Cardinals vs Astros RBI Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +165 0.5 -220
Christian Walker (HOU) 0.5 +165 0.5 -220
Yainer Diaz (HOU) 0.5 +175 0.5 -235
Jeremy Pena (HOU) 0.5 +200 0.5 -275
Nolan Arenado (STL) 0.5 +210 0.5 -295

Cardinals vs Astros Strikeout Prop Bets Today

Over Under
Erick Fedde (STL) 3.5 -160 3.5 +125
Hunter Brown (HOU) 5.5 -125 5.5 -105

Hunter Brown has induced opposing hitters to ground into 3 double plays in 5 opportunities (60%) this season — best among qualified SPs in MLB; League Avg: 12% — 100th Percentile.

Hunter Brown has not walked any of the 27 batters that he has faced when going through the lineup the first time in a game this season — tied for best among qualified SPs in MLB; League Avg: 8% — 100th Percentile.

Opponents have a Hard-Hit Rate of just 29% (77/261) against Hunter Brown on fastballs since last season — best among qualified SPs in MLB; League Avg: 45% — 100th Percentile.

Opponents had a Hard-Hit Rate of just 29% (69/237) against Hunter Brown on fastballs in the 2024 season — best among qualified SPs in MLB; League Avg: 45% — 100th Percentile.

Cardinals Starting Pitcher Stats & Trends

Erick Fedde had a strike rate of just 57% (522/908) in two strike counts in the 2024 season — 2nd lowest among qualified SPs in MLB; League Avg: 65% — third Percentile.

Erick Fedde has a strike rate of just 50% (577/1,149) when ahead in the count since last season — lowest among qualified SPs in MLB; League Avg: 61% — first Percentile.

Erick Fedde has a strike rate of just 57% (557/969) in two strike counts since last season — lowest among qualified SPs in MLB; League Avg: 65% — first Percentile.

Erick Fedde had a strike rate of just 62% (1,781/2,891) in the 2024 season — 4th lowest among qualified SPs in MLB; League Avg: 65% — sixth Percentile.

Astros Keys to the Game vs. the Cardinals

The Astros were just 0-56 (.000) when trailing entering the 9th inning in the 2024 season — tied for lowest in MLB; League Avg: .050.

The Astros are just 0-7 (.000) after a win this season — tied for lowest in MLB; League Avg: .478.

The Astros are just 13-23 (.361) when tied entering the 8th inning since the 2023 season — 3rd lowest in MLB; League Avg: .500.

The Astros are just 4-5 (.444) at home this season — tied for 5th lowest in MLB; League Avg: .611.

Cardinals Keys to the Game vs. the Astros

The Cardinals are just 31-71 (.304) when their opponents score in the first inning since the 2023 season — 5th lowest in MLB; League Avg: .373.

The Cardinals are 29-20 (.592) when tied entering the 7th inning since the 2023 season — 4th best in MLB; League Avg: .499.

The Cardinals are 71-4 (.947) when leading entering the 8th inning since last season — tied for 3rd best in MLB; League Avg: .901.

The Cardinals are just 50-52 (.490) vs bottom 10 scoring offenses since the 2023 season They play the Astros (10th best runs scored) today.

The Astros are batting .425 when facing the starting pitcher for the 3rd time in a game this season — best in MLB; League Avg: .249.

The Astros are batting just .133 against LHP this season — 2nd lowest in MLB; League Avg: .229.

Astros hitters have an OBP of .531 (49 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB; League Avg: .324.

Astros hitters averaged just 3.65 pitches per plate appearance against RHP in the 2024 season — lowest in MLB; League Avg: 3.89.

Cardinals hitters have an OBP of .377 (201 PA’s) against LHP this season — 2nd best in MLB; League Avg: .307.

The Cardinals are batting .287 this season — best in MLB; League Avg: .235.

Cardinals hitters have just 397 strikeouts in 1,956 PA’s (20%) against LHP since last season — 5th best in MLB; League Avg: 23%.

The Cardinals are batting .226 on pitches out of the zone this season — best in MLB; League Avg: .145.

Opponents have a miss rate of 28% against Astros pitchers since last season — 2nd best in MLB; League Avg: 25%.

Astros pitchers have a strikeout rate of 29% this season — best in MLB; League Avg: 23%.

Opponents have a miss rate of 29% against Astros pitchers this season — best in MLB; League Avg: 26%.

Opponents have a miss rate of 28% against Astros pitchers since the 2023 season — 2nd best in MLB; League Avg: 26%.

Opponents had a miss rate of just 23% against Cardinals pitchers in 2023 — 2nd lowest in MLB; League Avg: 26%.

The Cardinals have allowed 8.17 runs per game (49/6) on the road this season — highest in MLB; League Avg: 4.71.

Cardinals pitchers had a strikeout rate of just 38% with two-strikes in 2023 — tied for 2nd lowest in MLB; League Avg: 43%.

Cardinals pitchers walked 95 of 1,431 batters (7%) when facing the leadoff batter in the inning in 2023 — 2nd best in MLB; League Avg: 8%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.