Astros vs Cubs Prediction, Odds & Player Prop Bets Today – MLB, Apr 25

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Chicago Cubs' Nico Hoerner watches his RBI sacrifice fly during the fifth inning of a baseball game against the Colorado Rockies Saturday, Sept. 23, 2023, in Chicago. Chicago won 6-3. (AP Photo/Paul Beaty)
(AP Photo/Paul Beaty)
BetMGM Betting @BETMGM Apr 25, 2024, 11:00 AM
  • The Astros are -130 favorites vs the Cubs
  • Astros vs Cubs Over / Under today: 8 Runs
  • Astros / Cubs TV Channel: MARQ | SCHN

The Houston Astros (-125) visit Wrigley Field to take on the Chicago Cubs (+105) on Thursday, April 25, 2024. First pitch is scheduled for 2:20pm EDT in Chicago, IL.

This season, the Astros are 7-18 against the spread (ATS), while the Cubs are 17-7 ATS.

Astros vs Cubs Starting Pitchers Today:

  • Astros starting pitcher: Justin Verlander 1-0, 3.00 ERA
  • Cubs starting pitcher: Javier Assad 2-0, 2.11 ERA

Astros vs. Cubs Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Astros-1.5 +140O 7.5 -110-125
Cubs +1.5 -165U 7.5 -110+105

Astros vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Thursday‘s MLB game with 53.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Astros vs Cubs and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Astros players for Thursday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

  • Michael Brantley has hit the Home Runs Over in 2 of his last 8 away games (+7.00 Units / 88% ROI)
  • Michael Brantley has hit the Runs Under in 8 of his last 9 games (+5.65 Units / 30% ROI)
  • Michael Brantley has hit the Hits Under in 8 of his last 14 games (+5.45 Units / 29% ROI)
  • Michael Brantley has hit the Hits Runs and RBIs Under in 9 of his last 12 games (+5.20 Units / 35% ROI)
  • Michael Brantley has hit the Singles Under in 6 of his last 7 away games (+5.10 Units / 67% ROI)

And here are some favorite MLB player prop bets for Cubs players for Thursday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

  • No trends found
  • The Houston Astros have hit the Moneyline in 36 of their last 48 away games (+20.35 Units / 31% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 40 of their last 60 away games (+16.18 Units / 22% ROI)
  • The Houston Astros have covered the Run Line in 40 of their last 62 away games (+15.50 Units / 18% ROI)
  • The Houston Astros have hit the Game Total Over in 37 of their last 61 games (+15.00 Units / 22% ROI)
  • The Houston Astros have hit the Team Total Over in 34 of their last 51 away games (+13.80 Units / 23% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 38 of their last 66 games (+9.21 Units / 12% ROI)
  • The Chicago Cubs have hit the Game Total Under in 21 of their last 32 games (+8.75 Units / 25% ROI)
  • The Chicago Cubs have hit the Moneyline in 23 of their last 34 games at home (+7.75 Units / 15% ROI)
  • The Chicago Cubs have covered the Run Line in 36 of their last 68 games at home (+7.75 Units / 10% ROI)
  • The Chicago Cubs have hit the Team Total Over in 35 of their last 61 games at home (+6.79 Units / 10% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 8-17 against the Run Line (+0 Units / 0% ROI).

  • 7-18 when betting on the Moneyline for +0 Units / 0% ROI
  • 8-15 when betting on the total runs Over for +0 Units / 0% ROI
  • 15-8 when betting on the total runs Under for +0 Units / 0% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 17-7 against the Run Line (+0 Units / 0% ROI).

  • 15-9 when betting on the Moneyline for +0 Units / 0% ROI
  • 11-13 when betting on the total runs Over for +0 Units / 0% ROI
  • 13-11 when betting on the total runs Under for +0 Units / 0% ROI

Cubs vs Astros Home Run Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +350 0.5 -450
Christopher Morel (CHC) 0.5 +475 0.5 -650
Kyle Tucker (HOU) 0.5 +650 0.5 -1100
Matt Mervis (CHC) 0.5 +650 0.5 -1000
Michael Busch (CHC) 0.5 +650 0.5 -1100

Cubs vs Astros Total Hits Prop Bets Today

Over Under
Nico Hoerner (CHC) 0.5 -250 0.5 +180
Yordan Alvarez (HOU) 0.5 -250 0.5 +180
Kyle Tucker (HOU) 0.5 -225 0.5 +170
Yainer Diaz (HOU) 0.5 -225 0.5 +165
Jeremy Pena (HOU) 0.5 -210 0.5 +155

Cubs vs Astros RBI Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +150 0.5 -200
Yainer Diaz (HOU) 0.5 +165 0.5 -225
Kyle Tucker (HOU) 0.5 +170 0.5 -225
Alex Bregman (HOU) 0.5 +170 0.5 -225
Christopher Morel (CHC) 0.5 +180 0.5 -250

Cubs vs Astros Strikeout Prop Bets Today

Over Under

Opponents are hitting just .227 (15-for-66) against Justin Verlander on the first pitch of at-bats since last season — best in MLB among starting pitchers with at least 74 total IP; League Avg: .350 — 100th Percentile.

Justin Verlander has allowed an OPS of just .542 (495 PA’s) when going through the lineup the second time in a game since the 2022 season — 2nd best in MLB among starting pitchers with at least 138 total IP; League Avg: .712 — 98th Percentile.

Justin Verlander has allowed an OBP of just .249 (494 PA’s) when going through the lineup the second time in a game since the 2022 season — 3rd best in MLB among starting pitchers with at least 138 total IP; League Avg: .307 — 97th Percentile.

Justin Verlander has allowed a slugging percentage of just .268 (162 Total Bases / 605 ABs) vs left-handed batters since the 2022 season — best in MLB among starting pitchers with at least 138 total IP; League Avg: .401 — 100th Percentile.

Cubs Starting Pitcher Stats & Trends

Opponents are hitting just .129 (15-for-116) against Javier Assad with runners in scoring position since last season — best in MLB among starting pitchers with at least 74 total IP; League Avg: .255 — 100th Percentile.

Javier Assad has allowed an OPS of just .408 (134 PA’s) with runners in scoring position since last season — best in MLB among starting pitchers with at least 74 total IP; League Avg: .740 — 100th Percentile.

Javier Assad has a strike rate of just 61% (635/1,047) against right-handed batters since last season — 4th lowest in MLB among starting pitchers with at least 74 total IP; League Avg: 65% — second Percentile.

Opponents have a Hard-Hit Rate of just 19% (5/26) against Javier Assad on fastballs this season — best in MLB among starting pitchers with at least 9 total IP; League Avg: 46% — 100th Percentile.

Astros Keys to the Game vs. the Cubs

The Astros are 16-15 (.516) after a loss as underdogs since the 2022 season — 4th best in MLB; League Avg: .410.

The Astros are 96-25 (.793) when they’ve hit 2 or more home runs since the 2022 season — 3rd best in MLB; League Avg: .697.

The Astros are 42-26 (.618) after a road loss since the 2022 season — 2nd best in MLB; League Avg: .461.

The Astros are 13-11 (.542) after a loss as underdogs since the 2023 season — 5th best in MLB; League Avg: .424.

Cubs Keys to the Game vs. the Astros

The Cubs are just 35-38 (.479) after a loss as favorites since the 2022 season — 3rd lowest in MLB; League Avg: .589.

The Cubs are 22-18 (.550) after a loss as underdogs since the 2023 season — 4th best in MLB; League Avg: .424.

The Cubs are just 21-27 (.438) when tied entering the 7th inning since the 2022 season — 5th lowest in MLB; League Avg: .500.

Astros hitters have just 699 strikeouts in 3,955 PA’s (18%) against LHP since the 2022 season — best in MLB; League Avg: 22%.

Astros hitters are slugging .547 in lefty-lefty matchups since last season — best in MLB; League Avg: .374.

14% of Astros’ hitters plate appearances have lasted only one pitch (1,786/13,273 PA’s) since the 2022 season — highest in MLB; League Avg: 11%.

The Astros have won 90% of road games in which they have scored three or more runs in an inning since the 2022 season — highest in MLB; League Avg: 74%.

The Cubs are batting just .186 with two outs this season — 2nd lowest in MLB; League Avg: .230.

The Cubs have a winning percentage of 75% at home this season — tied for best in MLB; League Avg: 49%.

Cubs hitters are slugging .461 against LHP since last season — 3rd best in MLB; League Avg: .414.

Cubs hitters have an OPS of .867 (184 PA’s) against LHP this season — best in MLB; League Avg: .699.

Opponents have a groundball batting average of .333 against Astros pitchers with runners on base this season — 2nd highest in MLB; League Avg: .260.

Astros pitchers have allowed opponents to score in three different innings in 38% of their games since the 2022 season — lowest in MLB; League Avg: 46%.

Astros pitchers have an ERA of 5.91 (105.0 IP) over the last 14 days — 2nd highest in MLB; League Avg: 3.82.

Astros pitchers have a strikeout rate of 45% with two-strikes since the 2022 season — tied for 2nd best in MLB; League Avg: 42%.

The Cubs pitchers allowed an average Exit Velocity of just 88.3 MPH in the 2023 season (4,045 balls in play) — 2nd best in MLB; League Avg: 89.0

Cubs pitchers allowed an average Exit Velocity of 88.3 MPH (4,045 batted balls) in the 2023 season — 2nd best in MLB; League Avg: 89.0.

The Cubs pitchers have allowed their opponents to score first in just 29% of their games this season — 3rd lowest in MLB; League Avg: 50%.

Opponents have a groundball batting average of just .230 against Cubs pitchers with runners on base since last season — 2nd best in MLB; League Avg: .259.

Cubs vs. Astros Injuries Tonight That May Affect Prop Bets 

  • Patrick Wisdom (Chicago Cubs): Back, 10-Day IL
  • Justin Steele (Chicago Cubs): Hamstring, 15-Day IL
  • Brennen Davis (Chicago Cubs): Undisclosed, Out
  • Tyler Duffey (Chicago Cubs): Back, Day-To-Day
  • Jameson Taillon (Chicago Cubs): Back, 15-Day IL
  • Caleb Kilian (Chicago Cubs): Shoulder, 60-Day IL
  • Grae Kessinger (Houston Astros): Hamstring, Day-To-Day
  • Justin Verlander (Houston Astros): Shoulder, 15-Day IL
  • Penn Murfee (Houston Astros): Elbow, 15-Day IL
  • Kendall Graveman (Houston Astros): Shoulder, 60-Day IL
  • Jose Abreu (Houston Astros): Hand, Day-To-Day
  • Jose Urquidy (Houston Astros): Forearm, 15-Day IL
  • Oliver Ortega (Houston Astros): Elbow, 15-Day IL
  • Lance McCullers (Houston Astros): Forearm, 60-Day IL
  • Bennett Sousa (Houston Astros): Shoulder, 15-Day IL
  • Forrest Whitley (Houston Astros): Finger, 7-Day IL
  • Shawn Dubin (Houston Astros): Forearm, 15-Day IL

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.