Astros vs Padres Prediction, Odds & Player Prop Bets Today – MLB, Sep 16

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San Diego Padres' Jake Cronenworth during a baseball game against the San Francisco Giants in San Francisco, Wednesday, June 21, 2023.
(AP Photo/Jeff Chiu)
BetMGM Betting @BETMGM Sep 16, 2024, 11:00 AM
  • The Padres are -140 favorites vs the Astros
  • Astros vs Padres Over / Under today: 8 Runs
  • Astros / Padres TV Channel: SCHN | PDTV | MLBN

The Houston Astros (+105) visit Petco Park to take on the San Diego Padres (-125) on Monday, September 16, 2024. First pitch is scheduled for 9:40pm EDT in San Diego, CA.

This season, the Astros are 81-68 against the spread (ATS), while the Padres are 75-75 ATS.

Astros vs Padres Starting Pitchers Today:

  • Astros starting pitcher: Spencer Arrighetti 7-12, 4.76 ERA
  • Padres starting pitcher: Yu Darvish 5-3, 3.54 ERA

Astros vs. Padres Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Astros+1.5 -210O 8 -115+105
Padres -1.5 +170U 8 -105-125

Astros vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Monday‘s MLB game with 53.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Astros players for Monday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

  • Jeremy Pena has hit the Home Runs Over in 7 of his last 25 away games (+38.40 Units / 154% ROI)
  • Yainer Diaz has hit the Hits Over in 24 of his last 46 games (+16.70 Units / 32% ROI)
  • Yainer Diaz has hit the Total Bases Over in 29 of his last 47 games (+13.25 Units / 27% ROI)
  • Ben Gamel has hit the Runs Over in 15 of his last 25 games (+13.05 Units / 52% ROI)
  • Yainer Diaz has hit the Hits Runs and RBIs Over in 31 of his last 47 games (+11.90 Units / 19% ROI)

And here are some favorite MLB player prop bets for Padres players for Monday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

  • Jackson Merrill has hit the Home Runs Over in 10 of his last 40 games (+31.40 Units / 79% ROI)
  • Luis Arraez has hit the Singles Over in 27 of his last 32 games (+18.60 Units / 29% ROI)
  • Jackson Merrill has hit the Total Bases Over in 29 of his last 48 games (+14.70 Units / 29% ROI)
  • Luis Arraez has hit the Hits Over in 19 of his last 32 games (+13.30 Units / 39% ROI)
  • Manny Machado has hit the RBIs Over in 24 of his last 43 games (+12.95 Units / 29% ROI)
  • The Houston Astros have covered the Run Line in 53 of their last 91 games (+18.85 Units / 17% ROI)
  • The Houston Astros have hit the Game Total Under in 76 of their last 132 games (+17.25 Units / 12% ROI)
  • The Houston Astros have hit the Moneyline in 48 of their last 76 games (+11.10 Units / 10% ROI)
  • The Houston Astros have hit the Team Total Over in 63 of their last 113 games (+7.30 Units / 6% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Team Total Under in 32 of their last 55 games (+5.30 Units / 8% ROI)
  • The San Diego Padres have hit the Moneyline in 48 of their last 73 games (+16.50 Units / 16% ROI)
  • The San Diego Padres have hit the Game Total Over in 43 of their last 72 games (+13.55 Units / 17% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 29 of their last 50 games (+6.35 Units / 11% ROI)
  • The San Diego Padres have covered the Run Line in 61 of their last 118 games (+5.77 Units / 4% ROI)
  • The San Diego Padres have hit the Team Total Over in 24 of their last 42 games at home (+2.75 Units / 6% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 76-73 against the Run Line (+6.1 Units / 3.37% ROI).

  • 81-68 when betting on the Moneyline for -8.9 Units / -4.09% ROI
  • 61-84 when betting on the total runs Over for -30.68 Units / -18.85% ROI
  • 84-61 when betting on the total runs Under for +16.4 Units / 9.92% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 75-75 against the Run Line (+2.67 Units / 1.44% ROI).

  • 85-65 when betting on the Moneyline for +4.7 Units / 2.33% ROI
  • 81-66 when betting on the total runs Over for +8.95 Units / 5.46% ROI
  • 66-81 when betting on the total runs Under for -23.95 Units / -14.39% ROI

Padres vs Astros Home Run Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +250 0.5 -300
Kyle Tucker (HOU) 0.5 +340 0.5 -450
Fernando Tatis Jr. (SD) 0.5 +360 0.5 -500
Manny Machado (SD) 0.5 +400 0.5 -550
Jackson Merrill (SD) 0.5 +550 0.5 -800

Padres vs Astros Total Hits Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 -275 0.5 +195
Yainer Diaz (HOU) 0.5 -250 0.5 +180
Fernando Tatis Jr. (SD) 0.5 -250 0.5 +175
Jose Altuve (HOU) 0.5 -225 0.5 +165
Manny Machado (SD) 0.5 -225 0.5 +170

Padres vs Astros RBI Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +130 0.5 -165
Manny Machado (SD) 0.5 +140 0.5 -185
Kyle Tucker (HOU) 0.5 +155 0.5 -210
Alex Bregman (HOU) 0.5 +165 0.5 -225
Fernando Tatis Jr. (SD) 0.5 +170 0.5 -225

Padres vs Astros Strikeout Prop Bets Today

Over Under
Spencer Arrighetti (HOU) 4.5 -130 4.5 +100
Yu Darvish (SD) 4.5 -105 4.5 -120

Spencer Arrighetti has allowed a slugging percentage of .688 (33 Total Bases / 48 ABs) on low fastballs this season — 2nd highest in MLB among starting pitchers with at least 59 total IP; League Avg: .403 — second Percentile.

Spencer Arrighetti has allowed an OPS of 1.046 (221 PA’s) versus the top of the order this season — highest in MLB among starting pitchers with at least 59 total IP; League Avg: .757 — 0 Percentile.

Spencer Arrighetti has walked 30 of 221 batters (14%) versus the top of the order this season — 4th highest in MLB among starting pitchers with at least 59 total IP; League Avg: 8% — third Percentile.

Spencer Arrighetti has a strikeout rate of 51% (74 SO in 144 PAs) on low non-fastballs this season — 4th best in MLB among starting pitchers with at least 59 total IP; League Avg: 33% — 97th Percentile.

Padres Starting Pitcher Stats & Trends

Yu Darvish has thrown his slider 50% of the time (323/643) when he’s behind in the count since last season — highest in MLB among starting pitchers with at least 124 total SL; League Avg: 18% — 100th Percentile.

Opponents are hitting just .146 (28-for-192) against Yu Darvish on fastballs away since the 2022 season — 2nd best in MLB among starting pitchers with at least 188 total IP; League Avg: .240 — 99th Percentile.

Yu Darvish has thrown breaking pitches 57% of the time (364/643) when behind in the count since last season — 2nd highest in MLB among starting pitchers with at least 124 total IP; League Avg: 23% — 99th Percentile.

Yu Darvish has allowed a slugging percentage of just .229 (44 Total Bases / 192 ABs) on fastballs away since the 2022 season — 3rd best in MLB among starting pitchers with at least 188 total IP; League Avg: .375 — 98th Percentile.

Astros Keys to the Game vs. the Padres

The Astros are just 10-22 (.312) when tied entering the 8th inning since the 2023 season — lowest in MLB; League Avg: .500.

The Astros are just 3-12 (.200) when tied entering the 8th inning this season — lowest in MLB; League Avg: .500.

The Astros are just 0-51 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .052.

The Astros are just 4-10 (.286) after a loss as underdogs this season — 2nd lowest in MLB; League Avg: .434.

Padres Keys to the Game vs. the Astros

The Padres are 124-21 (.855) when scoring 5 or more runs since the 2023 season — 3rd best in MLB; League Avg: .791.

The Padres are 60-4 (.938) when leading entering the 7th inning this season — 3rd best in MLB; League Avg: .857.

The Padres are 19-45 (.297) when allowing 5 or more runs this season — 2nd best in MLB; League Avg: .197.

The Padres are 8-4 (.667) when tied entering the 8th inning this season — tied for 2nd best in MLB; League Avg: .500.

Astros hitters have just 944 strikeouts in 5,211 PA’s (18%) against LHP since the 2022 season — best in MLB; League Avg: 22%.

Astros hitters are averaging just 3.65 pitches per plate appearance against RHP this season — lowest in MLB; League Avg: 3.89.

15% of Astros’ hitters plate appearances have lasted only one pitch (876/5,648 PA’s) this season — highest in MLB; League Avg: 12%.

14% of Astros’ hitters plate appearances have lasted only one pitch (2,537/17,955 PA’s) since the 2022 season — highest in MLB; League Avg: 11%.

Padres hitters have just 253 strikeouts in 1,510 PA’s (17%) against LHP this season — best in MLB; League Avg: 22%.

The Padres are batting .500 when facing the starting pitcher for the 3rd time in a game over the last 14 days — best in MLB; League Avg: .244.

Padres hitters have just 733 strikeouts in 4,159 PA’s (18%) against RHP this season — best in MLB; League Avg: 22%.

Padres hitters have just 4 strikeouts in 39 PA’s (10%) against LHP this month (9 games) — best in MLB; League Avg: 24%.

Astros pitchers have a strikeout rate of 24% this season — 2nd best in MLB; League Avg: 22%.

Astros pitchers have an ERA of 3.52 (2071.1 IP) on the road since the 2022 season — best in MLB; League Avg: 4.26.

Astros pitchers have a strikeout rate of 24% since last season — 4th best in MLB; League Avg: 23%.

The average home run distance against the Astros pitchers this season is 387.8 feet — best in MLB; League Avg: 397.5

Padres pitchers allowed an average Exit Velocity of 87.9 MPH (3,922 batted balls) in the 2023 season — best in MLB; League Avg: 89.0.

The Padres pitchers allowed an average Exit Velocity of just 87.9 MPH in the 2023 season (3,922 balls in play) — best in MLB; League Avg: 89.0

Padres pitchers have walked 14 of 109 batters (13%) when facing the leadoff batter in the inning this month (12 games) — highest in MLB; League Avg: 8%.

Padres pitchers have a strikeout rate of 24% since the 2022 season — 5th best in MLB; League Avg: 23%.

Padres vs. Astros Injuries Tonight That May Affect Prop Bets 

  • San Diego Padres – No Injuries Reported
  • Houston Astros – No Injuries Reported

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.