Athletics vs Astros Prediction, Odds & Player Prop Bets Today – MLB, May 27

Houston Astros' Yordan Alvarez runs up the first base line against the Los Angeles Angels during the fourth inning of a baseball game Sunday, June 4, 2023, in Houston.
(AP Photo/David J. Phillip)
  • The Astros are -220 favorites vs the Athletics
  • Athletics vs Astros Over / Under today: 7.5 Runs
  • Athletics / Astros TV Channel: SCHN | NSCA

The Oakland Athletics (+170) visit Daikin Park to take on the Houston Astros (-220) on Tuesday, May 27, 2025. First pitch is scheduled for 8:10pm EDT in Houston, TX.

This season, the Athletics are against the spread (ATS), while the Astros are 29-24 ATS.

Athletics vs Astros Starting Pitchers Today:

  • Athletics starting pitcher: JP Sears 4-4, 3.98 ERA
  • Astros starting pitcher: Hunter Brown 6-3, 2.03 ERA

Athletics vs. Astros Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Athletics+1.5 -118O 7.5 -102+170
Astros -1.5 -102U 7.5 -118-220

Athletics vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Tuesday‘s MLB game with 63.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Athletics players for Tuesday‘s game, looking at profitable historical betting trends:

Best Athletics Player Prop Bets Today:

And here are some favorite MLB player prop bets for Astros players for Tuesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

Athletics Against the Spread (ATS) Record

Against the spread this season, the Athletics are against the Run Line ( Units / ROI).

  • away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
  • away total over record when betting on the total runs Over for over units Units / over ROI ROI
  • away total under record when betting on the total runs Under for under units Units / under ROI ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 29-24 against the Run Line (+6.77 Units / 9.93% ROI).

  • 28-25 when betting on the Moneyline for -2.2 Units / -3.28% ROI
  • 21-30 when betting on the total runs Over for -12 Units / -20.64% ROI
  • 30-21 when betting on the total runs Under for +6.75 Units / 11.53% ROI

Astros vs Athletics Home Run Prop Bets Today

Over Under
Christian Walker (HOU) 0.5 +325 0.5 -450
Isaac Paredes (HOU) 0.5 +475 0.5 -650
Yainer Diaz (HOU) 0.5 +500 0.5 -750
Jose Altuve (HOU) 0.5 +500 0.5 -700
Brent Rooker (ATH) 0.5 +500 0.5 -700

Astros vs Athletics Total Hits Prop Bets Today

Over Under
Jacob Wilson (ATH) 0.5 -275 0.5 +200
Christian Walker (HOU) 0.5 -225 0.5 +170
Jake Meyers (HOU) 0.5 -220 0.5 +165
Isaac Paredes (HOU) 0.5 -200 0.5 +155
Miguel Andujar (ATH) 0.5 -190 0.5 +140

Astros vs Athletics RBI Prop Bets Today

Over Under
Christian Walker (HOU) 0.5 +130 0.5 -175
Isaac Paredes (HOU) 0.5 +145 0.5 -190
Yainer Diaz (HOU) 0.5 +155 0.5 -210
Jose Altuve (HOU) 0.5 +160 0.5 -210
Jeremy Pena (HOU) 0.5 +180 0.5 -250

Astros vs Athletics Strikeout Prop Bets Today

Over Under
JP Sears (ATH) 3.5 -118 3.5 -110
Hunter Brown (HOU) 6.5 -110 6.5 -115

63% of JP Sears’ strikeouts are in the zone since last season — 2nd highest among qualified SPs in MLB; League Avg: 49% — 98th Percentile.

JP Sears had a strikeout rate of just 16% (47/288) when going through the lineup the first time in a game in the 2024 season — lowest among qualified SPs in MLB; League Avg: 25% — first Percentile.

Opponents had a two strike miss rate of just 20% (111/541) against JP Sears in the 2024 season — 4th lowest among qualified SPs in MLB; League Avg: 25% — sixth Percentile.

Right-handed hitters have a miss rate of just 20% (294/1,502) against JP Sears since last season — tied for 2nd lowest among qualified SPs in MLB; League Avg: 27% — sixth Percentile.

Astros Starting Pitcher Stats & Trends

Opponents are hitting just .118 (10-for-85) against Hunter Brown when going through the lineup the second time in a game this season — best among qualified SPs in MLB; League Avg: .231 — 100th Percentile.

Hunter Brown has allowed an OBP of just .167 (90 PA’s) when going through the lineup the second time in a game this season — 2nd best among qualified SPs in MLB; League Avg: .290 — 98th Percentile.

Hunter Brown has induced opposing hitters to ground into 8 double plays in 24 opportunities (33%) this season — best among qualified SPs in MLB; League Avg: 11% — 100th Percentile.

52% of Hunter Brown’s strikeouts have come on 97+ MPH fastballs this season — highest among qualified SPs in MLB; League Avg: 8% — 100th Percentile.

Athletics Keys to the Game vs. the Astros

The Athletics are just 9-19 (.321) at home this season — 2nd lowest in MLB; League Avg: .561.

The Athletics are just 17-3 (.850) when leading entering the 9th inning this season — 2nd lowest in MLB; League Avg: .957.

The Athletics are just 142-235 (.376) since the 2023 season — 3rd lowest in MLB; League Avg: .500.

The Athletics are just 73-117 (.384) at home since the 2023 season — 2nd lowest in MLB; League Avg: .527.

Astros Keys to the Game vs. the Athletics

The Astros were just 0-56 (.000) when trailing entering the 9th inning in the 2024 season — tied for lowest in MLB; League Avg: .050.

The Astros are just 1-79 (.012) when trailing entering the 9th inning since last season — 3rd lowest in MLB; League Avg: .048.

The Astros were just 5-13 (.278) when tied entering the 8th inning in the 2024 season — 3rd lowest in MLB; League Avg: .500.

The Astros are 51-48 (.515) vs top 10 scoring offenses since the 2023 season They play the Athletics (26th best runs scored) today.

The Athletics batted just .223 in 2023 — lowest in MLB; League Avg: .248.

Athletics hitters had an OBP of just .294 (2,935 PA’s) at home in 2023 — 2nd lowest in MLB; League Avg: .324.

The Athletics batted just .200 with two outs in 2023 — lowest in MLB; League Avg: .237.

The Athletics batted just .232 against LHP in the 2023 season — tied for lowest in MLB; League Avg: .254.

Astros hitters averaged just 3.65 pitches per plate appearance against RHP in the 2024 season — lowest in MLB; League Avg: 3.89.

Astros hitters are averaging just 3.68 pitches per plate appearance against RHP since last season — lowest in MLB; League Avg: 3.89.

Astros hitters have put just 33% of balls in play to the right side of the field since the 2023 season — lowest in MLB; League Avg: 37%.

Astros hitters are averaging just 3.74 pitches per plate appearance against RHP since the 2023 season — lowest in MLB; League Avg: 3.90.

Opponents have a groundball rate of just 34% against Athletics pitchers over the last 14 days — lowest in MLB; League Avg: 42%.

Opponents had a groundball rate of just 38% against Athletics pitchers in 2023 — lowest in MLB; League Avg: 43%.

Athletics pitchers walked 694 of 6,384 batters (11%) in 2023 — highest in MLB; League Avg: 9%.

Athletics pitchers had an ERA of 5.48 (1419.2 IP) in 2023 — 2nd highest in MLB; League Avg: 4.33.

Opponents have a miss rate of 28% against Astros pitchers this season — 2nd best in MLB; League Avg: 25%.

Opponents have a miss rate of 28% against Astros pitchers since last season — 2nd best in MLB; League Avg: 25%.

Batters facing the Astros pitchers have struck out in the zone 46% of the time this season — 3rd lowest in MLB; League Avg: 50%. this season — 3rd lowest in MLB; League Avg: 50%.

Astros pitchers have a strikeout rate of 30% in close and late situations this season — best in MLB; League Avg: 23%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.