Brewers vs Giants Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

(AP Photo/Matt York)
  • The Giants are -140 favorites vs the Brewers
  • Brewers vs Giants Over / Under today: 8 Runs
  • Brewers / Giants TV Channel: NSBA | FDWI | MLBN

The Milwaukee Brewers (+118) visit Oracle Park to take on the San Francisco Giants (-140) on Monday, April 21, 2025. First pitch is scheduled for 9:45pm EDT in San Francisco, CA, CA.

This season, the Brewers are 12-10 against the spread (ATS), while the Giants are 12-10 ATS.

Brewers vs Giants Starting Pitchers Today:

  • Brewers starting pitcher: Quinn Priester 1-0, 0.90 ERA
  • Giants starting pitcher: Robbie Ray 3-0, 4.19 ERA

Brewers vs. Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Brewers+1.5 -190O 8 -115+118
Giants -1.5 +155U 8 -105-140

Brewers vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Monday‘s MLB game with 56.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Brewers players for Monday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Bets Today:

  • Brice Turang has hit the Home Runs Over in 2 of his last 8 away games (+22.00 Units / 275% ROI)
  • Brice Turang has hit the Hits Over in 20 of his last 25 games (+15.60 Units / 35% ROI)
  • Brice Turang has hit the Total Bases Over in 17 of his last 25 games (+10.90 Units / 34% ROI)
  • Brice Turang has hit the Singles Over in 19 of his last 25 games (+10.20 Units / 28% ROI)
  • Brice Turang has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+8.65 Units / 28% ROI)

And here are some favorite MLB player prop bets for Giants players for Monday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

  • Mike Yastrzemski has hit the Home Runs Over in 2 of his last 4 games at home (+11.80 Units / 295% ROI)
  • Jung Hoo Lee has hit the Hits Over in 16 of his last 20 games (+9.05 Units / 21% ROI)
  • Jung Hoo Lee has hit the Total Bases Over in 16 of his last 25 games (+8.75 Units / 29% ROI)
  • Jung Hoo Lee has hit the Runs Over in 12 of his last 20 games (+8.20 Units / 41% ROI)
  • Jung Hoo Lee has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+7.30 Units / 25% ROI)
  • The Milwaukee Brewers have hit the Moneyline in 93 of their last 168 games (+3.90 Units / 2% ROI)
  • The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 91 of their last 168 games (+3.30 Units / 2% ROI)
  • The Milwaukee Brewers have covered the 1st Five Innings (F5) Run Line in 89 of their last 168 games (+2.45 Units / 1% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 90 of their last 162 games (+8.33 Units / 4% ROI)
  • The San Francisco Giants have hit the Game Total Over in 84 of their last 162 games (+7.15 Units / 4% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 72 of their last 162 games (+2.82 Units / 1% ROI)

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 10-12 against the Run Line (-2.75 Units / -10.28% ROI).

  • 12-10 when betting on the Moneyline for +1.2 Units / 4.37% ROI
  • 8-12 when betting on the total runs Over for -5.2 Units / -21.4% ROI
  • 12-8 when betting on the total runs Under for +3.3 Units / 13.69% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 12-10 against the Run Line (+2.9 Units / 9.85% ROI).

  • 14-8 when betting on the Moneyline for +5.25 Units / 20.04% ROI
  • 14-7 when betting on the total runs Over for +6.2 Units / 25.67% ROI
  • 7-14 when betting on the total runs Under for -8.5 Units / -35.05% ROI

Giants vs Brewers Home Run Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +400 0.5 -550
Willy Adames (SF) 0.5 +500 0.5 -750
Rhys Hoskins (MIL) 0.5 +500 0.5 -700
Mike Yastrzemski (SF) 0.5 +625 0.5 -1000
William Contreras (MIL) 0.5 +650 0.5 -1000

Giants vs Brewers Total Hits Prop Bets Today

Over Under
Willy Adames (SF) 0.5 -275 0.5 +195
Heliot Ramos (SF) 0.5 -275 0.5 +200
Brice Turang (MIL) 0.5 -250 0.5 +195
Jackson Chourio (MIL) 0.5 -220 0.5 +165
Mike Yastrzemski (SF) 0.5 -220 0.5 +160

Giants vs Brewers RBI Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +130 0.5 -165
Heliot Ramos (SF) 0.5 +150 0.5 -200
Willy Adames (SF) 0.5 +165 0.5 -220
Christian Yelich (MIL) 0.5 +165 0.5 -220
William Contreras (MIL) 0.5 +165 0.5 -220

Giants vs Brewers Strikeout Prop Bets Today

Over Under
Robbie Ray (SF) 5.5 -130 5.5 +100
Quinn Priester (MIL) 3.5 +100 3.5 -130

Quinn Priester has pitched 10.0 straight innings without allowing an earned run — Kodai Senga has the longest active streak at 22.2.

Quinn Priester has an ERA of 0.90 (10.0 IP)this season — tied for 7th best in MLB among starting pitchers with at least 8 total IP; League Avg: 3.90 — 96th Percentile.

Quinn Priester has located his breaking pitches down 87% of the time (34/39) this season — 3rd highest in MLB among starting pitchers with at least 8 total IP; League Avg: 64% — 98th Percentile.

Opponents have a chase percentage of just 22% (17/76) against Quinn Priester this season — 12th lowest in MLB among starting pitchers with at least 8 total IP; League Avg: 28% — seventh Percentile.

Giants Starting Pitcher Stats & Trends

Robbie Ray has walked 25% of batters when going through the lineup the first time in a game this season — highest in MLB among starting pitchers with at least 8 total IP; League Avg: 9% — 0 Percentile.

Robbie Ray has walked 18% of batters this season — 2nd highest in MLB among starting pitchers with at least 8 total IP; League Avg: 8% — first Percentile.

Robbie Ray has walked 33% of batters when going through the lineup the first time in a game this month (3 games) — highest in MLB among starting pitchers with at least 6 total IP; League Avg: 9% — 0 Percentile.

Robbie Ray has walked 21% of batters this month (3 games) — highest in MLB among starting pitchers with at least 6 total IP; League Avg: 8% — 0 Percentile.

Brewers Keys to the Game vs. the Giants

The Brewers are 27-16 (.628) when tied entering the 8th inning since the 2023 season — 2nd best in MLB; League Avg: .500.

The Brewers are 51-5 (.911) when they’ve had 5 or more XBH since the 2023 season — tied for best in MLB; League Avg: .801.

The Brewers are just 0-8 (.000) when allowing 5 or more runs this season — tied for lowest in MLB; League Avg: .166.

The Brewers are 54-35 (.607) vs the top 10 runs allowed teams since the 2023 season They play the Giants (16th best runs allowed) today.

Giants Keys to the Game vs. the Brewers

The Giants are 1-7 (.125) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .034.

The Giants are 2-6 (.250) when trailing entering the 8th inning this season — tied for best in MLB; League Avg: .081.

The Giants were just 20-24 (.455) vs bottom 10 scoring offenses in the 2024 season They play the Reds (16th best runs scored) today.

The Giants are 24-144 (.143) when trailing entering the 8th inning since the 2023 season — 4th best in MLB; League Avg: .098.

Brewers hitters had 129 extra-base hits out of 494 total hits (just 26%) with two-strikes in 2023 — lowest in MLB; League Avg: 33%.

Brewers hitters slugged just .378 against RHP in the 2023 season — 3rd lowest in MLB; League Avg: .413.

Brewers hitters averaged 4.03 pitches per plate appearance against RHP in the 2024 season — highest in MLB; League Avg: 3.89.

Brewers hitters are slugging just .391 on the first pitch of at-bats this season — 3rd lowest in MLB; League Avg: .580.

Giants hitters had an OPS of just .683 (1,790 PA’s) against LHP in the 2023 season — 3rd lowest in MLB; League Avg: .742.

The Giants batted just .151 with two-strikes in the 2023 season — 2nd lowest in MLB; League Avg: .172.

The Giants are batting just .098 on pitches out of the zone this season — 3rd lowest in MLB; League Avg: .145.

Giants hitters have struck out in 25% of it’s PA’s against LHP since the 2023 season — tied for 4th highest in MLB; League Avg: 23%.

Batters facing the Brewers pitchers have struck out in the zone 55% of the time since last season — highest in MLB; League Avg: 50%. since last season — highest in MLB; League Avg: 50%.

Opponents have a groundball rate of just 37% against Brewers pitchers this season — 2nd lowest in MLB; League Avg: 43%.

Batters facing the Brewers pitchers have struck out in the zone 59% of the time this season — highest in MLB; League Avg: 51%. this season — highest in MLB; League Avg: 51%.

Brewers pitchers have allowed opponents to score in three different innings in 38% of their games since the 2023 season — 2nd lowest in MLB; League Avg: 46%.

Opponents have a groundball rate of 49% against Giants pitchers since the 2023 season — highest in MLB; League Avg: 43%.

Opponents had a groundball rate of 49% against Giants pitchers in the 2024 season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 48% against Giants pitchers since last season — highest in MLB; League Avg: 43%.

Opponents had a groundball rate of 50% against Giants pitchers in 2023 — highest in MLB; League Avg: 43%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.