Brewers vs Giants Prediction, Odds & Player Prop Bets Today – MLB, Apr 22

FILE -San Francisco Giants third baseman J.D. Davis throws to first to get Los Angeles Dodgers designated hitter J.D. Martinez on a ground out during the first inning of a baseball game in Los Angeles, Friday, Sept. 22, 2023. Utilityman J.D. Davis went to a hearing Wednesday, Feb. 7, 2024 asking for a raise from $4.21 million to $6.9 million rather than the San Francisco Giants' $6.55 million offer.(AP Photo/Alex Gallardo, File)
(AP Photo/Alex Gallardo)
  • The Giants are -140 favorites vs the Brewers
  • Brewers vs Giants Over / Under today: 7.5 Runs
  • Brewers / Giants TV Channel: NSBA | FDWX

The Milwaukee Brewers (+118) visit Oracle Park to take on the San Francisco Giants (-140) on Tuesday, April 22, 2025. First pitch is scheduled for 9:45pm EDT in San Francisco, CA, CA.

This season, the Brewers are 12-11 against the spread (ATS), while the Giants are 13-10 ATS.

Brewers vs Giants Starting Pitchers Today:

  • Brewers starting pitcher: Jose Quintana 2-0, 0.71 ERA
  • Giants starting pitcher: Jordan Hicks 1-2, 6.05 ERA

Brewers vs. Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Brewers+1.5 -190O 7.5 -110+118
Giants -1.5 +155U 7.5 -110-140

Brewers vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Tuesday‘s MLB game with 54.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Brewers players for Tuesday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Bets Today:

  • Brice Turang has hit the Home Runs Over in 2 of his last 9 away games (+21.00 Units / 233% ROI)
  • Brice Turang has hit the Hits Over in 19 of his last 25 games (+13.60 Units / 31% ROI)
  • Christian Yelich has hit the Singles Under in 14 of his last 20 away games (+9.35 Units / 44% ROI)
  • Brice Turang has hit the Total Bases Over in 16 of his last 25 games (+8.45 Units / 27% ROI)
  • Garrett Mitchell has hit the Hits Runs and RBIs Under in 11 of his last 15 away games (+7.40 Units / 40% ROI)

And here are some favorite MLB player prop bets for Giants players for Tuesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

  • Wilmer Flores has hit the Home Runs Over in 2 of his last 4 games at home (+17.00 Units / 425% ROI)
  • Jung Hoo Lee has hit the Total Bases Over in 17 of his last 25 games (+10.80 Units / 36% ROI)
  • Jung Hoo Lee has hit the Hits Over in 16 of his last 20 games (+10.00 Units / 24% ROI)
  • Jung Hoo Lee has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+9.75 Units / 33% ROI)
  • Tyler Fitzgerald has hit the Singles Over in 11 of his last 20 games (+8.15 Units / 41% ROI)
  • The Milwaukee Brewers have hit the 1st Five Innings (F5) Moneyline in 13 of their last 19 games (+11.60 Units / 49% ROI)
  • The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 16 games (+10.50 Units / 54% ROI)
  • The Milwaukee Brewers have covered the 1st Five Innings (F5) Run Line in 14 of their last 19 games (+9.40 Units / 44% ROI)
  • The Milwaukee Brewers have hit the Game Total Under in 12 of their last 19 games (+6.65 Units / 32% ROI)
  • The Milwaukee Brewers have hit the Moneyline in 12 of their last 19 games (+4.40 Units / 18% ROI)
  • The San Francisco Giants have hit the Team Total Over in 15 of their last 21 games (+8.65 Units / 35% ROI)
  • The San Francisco Giants have hit the Moneyline in 14 of their last 21 games (+6.30 Units / 25% ROI)
  • The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 14 of their last 22 games (+5.55 Units / 21% ROI)
  • The San Francisco Giants have hit the Game Total Over in 13 of their last 21 games (+5.20 Units / 23% ROI)
  • The San Francisco Giants have covered the Run Line in 13 of their last 23 games (+4.45 Units / 15% ROI)

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 10-13 against the Run Line (-4.55 Units / -15.94% ROI).

  • 12-11 when betting on the Moneyline for +0.2 Units / 0.7% ROI
  • 8-13 when betting on the total runs Over for -6.3 Units / -24.8% ROI
  • 13-8 when betting on the total runs Under for +4.3 Units / 17.06% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 13-10 against the Run Line (+4.45 Units / 14.61% ROI).

  • 15-8 when betting on the Moneyline for +6.25 Units / 22.69% ROI
  • 14-8 when betting on the total runs Over for +5.1 Units / 20.2% ROI
  • 8-14 when betting on the total runs Under for -7.5 Units / -29.59% ROI

Giants vs Brewers Home Run Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +400 0.5 -525
Willy Adames (SF) 0.5 +525 0.5 -750
Heliot Ramos (SF) 0.5 +550 0.5 -800
Sam Huff (SF) 0.5 +775 0.5 -1400
Rhys Hoskins (MIL) 0.5 +775 0.5 -1400

Giants vs Brewers Total Hits Prop Bets Today

Over Under
Jung-hoo Lee (SF) 0.5 -275 0.5 +200
William Contreras (MIL) 0.5 -220 0.5 +170
Christian Yelich (MIL) 0.5 -210 0.5 +155
Luis Matos (SF) 0.5 -210 0.5 +160
Matt Chapman (SF) 0.5 -210 0.5 +155

Giants vs Brewers RBI Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +125 0.5 -160
William Contreras (MIL) 0.5 +160 0.5 -220
Christian Yelich (MIL) 0.5 +175 0.5 -235
Jung-hoo Lee (SF) 0.5 +175 0.5 -235
Wilmer Flores (SF) 0.5 +175 0.5 -225

Giants vs Brewers Strikeout Prop Bets Today

Over Under
Jose Quintana (MIL) 3.5 -130 3.5 +100
Jordan Hicks (SF) 4.5 +115 4.5 -150

Jose Quintana had a strike rate of just 57% (451/786) in two strike counts in the 2024 season — lowest among qualified SPs in MLB; League Avg: 65% — first Percentile.

Jose Quintana had a strike rate of just 59% (1,306/2,224) against right-handed batters in the 2024 season — lowest among qualified SPs in MLB; League Avg: 66% — first Percentile.

Jose Quintana had a strike rate of just 59% (1,676/2,819) in the 2024 season — lowest among qualified SPs in MLB; League Avg: 65% — first Percentile.

Jose Quintana has a strike rate of just 49% (723/1,464) when ahead in the count since the 2023 season — lowest in MLB among starting pitchers with at least 138 total IP; League Avg: 61% — 0 Percentile.

Giants Starting Pitcher Stats & Trends

Opponents are hitting just .065 (2-for-31) against Jordan Hicks when going through the lineup the second time in a game this season — best among among NL Starters; League Avg: .236 — 100th Percentile.

Opponents are hitting .387 (12-for-31) against Jordan Hicks when going through the lineup the first time in a game this season — tied for highest among qualified SPs in MLB; League Avg: .228 — second Percentile.

Jordan Hicks threw 423 fastballs at 100+ MPH in 2023 — most among NL Relievers — 100th Percentile.

Jordan Hicks has allowed an OBP of .354 (48 PA’s) with two-strikes this season — 2nd highest among qualified SPs in MLB; League Avg: .235 — second Percentile.

Brewers Keys to the Game vs. the Giants

The Brewers are 54-36 (.600) vs the top 10 runs allowed teams since the 2023 season They play the Giants (16th best runs allowed) today.

The Brewers are just 0-9 (.000) when allowing 5 or more runs this season — tied for lowest in MLB; League Avg: .165.

The Brewers are just 0-10 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .033.

The Brewers are 197-150 (.568) since the 2023 season — 5th best in MLB; League Avg: .500.

Giants Keys to the Game vs. the Brewers

The Giants are 1-7 (.125) when trailing entering the 9th inning this season — 2nd best in MLB; League Avg: .033.

The Giants are 2-6 (.250) when trailing entering the 8th inning this season — tied for best in MLB; League Avg: .082.

The Giants are 5-1 (.833) when they’ve scored in the first inning this season — tied for 3rd best in MLB; League Avg: .612.

The Giants are 10-6 (.625) on the road this season — best in MLB; League Avg: .389.

The Brewers have scored first in 74% of their games this season — tied for highest in MLB; League Avg: 50%.

Brewers hitters had 129 extra-base hits out of 494 total hits (just 26%) with two-strikes in 2023 — lowest in MLB; League Avg: 33%.

Brewers hitters came to the plate with runners in scoring position in 1,726 of their 6,170 plate appearances (28%) in the 2024 season — highest in MLB; League Avg: 25%.

Brewers hitters had a swing rate of just 45% in the 2024 season — 2nd lowest in MLB; League Avg: 48%.

Giants hitters have drawn walks in 22% of its PA’s against pitchers who have thrown at least 80 pitches in a game this season — best in MLB; League Avg: 9%.

Giants hitters had an OPS of just .683 (1,790 PA’s) against LHP in the 2023 season — 3rd lowest in MLB; League Avg: .742.

Giants hitters have an OPS of just .695 (9,279 PA’s) against RHP since the 2023 season — 5th lowest in MLB; League Avg: .721.

Giants hitters had an OBP of just .299 (4,384 PA’s) against RHP in the 2024 season — tied for 3rd lowest in MLB; League Avg: .311.

Batters facing the Brewers pitchers have struck out in the zone 55% of the time since last season — highest in MLB; League Avg: 50%. since last season — highest in MLB; League Avg: 50%.

The Brewers pitchers have allowed their opponents to score first in just 26% of their games this season — tied for lowest in MLB; League Avg: 50%.

Batters facing the Brewers pitchers have struck out in the zone 59% of the time this season — highest in MLB; League Avg: 51%. this season — highest in MLB; League Avg: 51%.

Brewers pitchers have allowed opponents to score in three different innings in 38% of their games since the 2023 season — 2nd lowest in MLB; League Avg: 46%.

Opponents had a groundball rate of 50% against Giants pitchers in 2023 — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 48% against Giants pitchers since last season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since the 2023 season — highest in MLB; League Avg: 43%.

Opponents had a groundball rate of 49% against Giants pitchers in the 2024 season — highest in MLB; League Avg: 43%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.