- The Orioles are -125 favorites vs the Cardinals
- Cardinals vs Orioles Over / Under today: 8 Runs
- Cardinals / Orioles TV Channel: MASN | FDMW | MLBN
The St. Louis Cardinals (+100) visit Oriole Park at Camden Yards to take on the Baltimore Orioles (-120) on Wednesday, May 28, 2025. First pitch is scheduled for 6:35pm EDT in Baltimore, MD.
This season, the Cardinals are 31-24 against the spread (ATS), while the Orioles are 18-35 ATS.
Cardinals vs Orioles Starting Pitchers Today:
- Cardinals starting pitcher: Miles Mikolas 4-2, 3.49 ERA
- Orioles starting pitcher: Cade Povich 1-3, 4.90 ERA
Cardinals vs. Orioles Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| Cardinals | +1.5 -220 | O 8 -102 | +100 |
| Orioles | -1.5 +165 | U 8 -118 | -120 |
Cardinals vs Orioles Prediction for Today’s Game
Based on recent trends the model predicts the Orioles will win Wednesday‘s MLB game with 52.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:
Best Cardinals Player Prop Bets Today:
- Pedro Pages has hit the Home Runs Over in 2 of his last 5 games (+15.00 Units / 300% ROI)
- Masyn Winn has hit the Hits Over in 18 of his last 25 away games (+8.30 Units / 19% ROI)
- Alec Burleson has hit the Total Bases Over in 11 of his last 15 games (+8.05 Units / 39% ROI)
- Miles Mikolas has hit the Earned Runs Under in 11 of his last 15 away games (+7.55 Units / 45% ROI)
- Alec Burleson has hit the Hits Runs and RBIs Over in 11 of his last 15 games (+7.35 Units / 44% ROI)
And here are some favorite MLB player prop bets for Orioles players for Wednesday‘s game, looking at profitable historical betting trends:
Best Orioles Player Prop Best Bets Today:
- Dylan Carlson has hit the Home Runs Over in 2 of his last 4 games (+19.00 Units / 475% ROI)
- Jackson Holliday has hit the Singles Over in 18 of his last 25 games (+9.85 Units / 31% ROI)
- Jackson Holliday has hit the Hits Over in 15 of his last 20 games at home (+9.75 Units / 30% ROI)
- Ryan O’Hearn has hit the Total Bases Over in 14 of his last 20 games at home (+8.65 Units / 30% ROI)
- Dylan Carlson has hit the Runs Under in 13 of his last 15 games (+8.30 Units / 25% ROI)
Cardinals Best Bets Today:
- The St. Louis Cardinals have covered the Run Line in 18 of their last 22 games (+15.55 Units / 52% ROI)
- The St. Louis Cardinals have hit the Moneyline in 22 of their last 32 games (+13.25 Units / 36% ROI)
- The St. Louis Cardinals have hit the Team Total Over in 32 of their last 55 games (+6.72 Units / 11% ROI)
- The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 10 of their last 14 away games (+6.10 Units / 37% ROI)
- The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 8 of their last 16 away games (+4.75 Units / 27% ROI)
Orioles Best Bets Today:
- The Baltimore Orioles have hit the Team Total Under in 31 of their last 49 games (+10.60 Units / 18% ROI)
- The Baltimore Orioles have hit the Game Total Over in 14 of their last 23 games at home (+6.35 Units / 25% ROI)
- The Baltimore Orioles have covered the 1st Five Innings (F5) Run Line in their last 6 games (+6.15 Units / 78% ROI)
- The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Under in 21 of their last 34 games (+5.39 Units / 12% ROI)
- The Baltimore Orioles have hit the 1st Five Innings (F5) Moneyline in 5 of their last 6 games (+5.05 Units / 81% ROI)
Cardinals Against the Spread (ATS) Record
Against the spread this season, the Cardinals are 33-22 against the Run Line (+6.75 Units / 8.7% ROI).
- 31-24 when betting on the Moneyline for +7.6 Units / 12.3% ROI
- 28-24 when betting on the total runs Over for +1.6 Units / 2.65% ROI
- 24-28 when betting on the total runs Under for -7 Units / -11.54% ROI
Orioles Against the Spread (ATS) Record
Against the spread this season, the Orioles are 18-35 against the Run Line (-21.21 Units / -30.19% ROI).
- 19-35 when betting on the Moneyline for -23.35 Units / -35.8% ROI
- 26-25 when betting on the total runs Over for -1.13 Units / -1.92% ROI
- 25-26 when betting on the total runs Under for -3.77 Units / -6.29% ROI
Orioles vs Cardinals Home Run Prop Bets Today
| Over | Under | |
|---|---|---|
| Gunnar Henderson (BAL) | 0.5 +450 | 0.5 -625 |
| Cedric Mullins (BAL) | 0.5 +550 | 0.5 -800 |
| Willson Contreras (STL) | 0.5 +600 | 0.5 -900 |
| Heston Kjerstad (BAL) | 0.5 +675 | 0.5 -1100 |
| Nolan Arenado (STL) | 0.5 +700 | 0.5 -1200 |
Orioles vs Cardinals Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Jackson Holliday (BAL) | 0.5 -275 | 0.5 +200 |
| Ramon Urias (BAL) | 0.5 -275 | 0.5 +195 |
| Brendan Donovan (STL) | 0.5 -235 | 0.5 +175 |
| Willson Contreras (STL) | 0.5 -220 | 0.5 +160 |
| Nolan Arenado (STL) | 0.5 -210 | 0.5 +155 |
Orioles vs Cardinals RBI Prop Bets Today
| Over | Under | |
|---|---|---|
| Gunnar Henderson (BAL) | 0.5 +155 | 0.5 -200 |
| Ryan Mountcastle (BAL) | 0.5 +165 | 0.5 -220 |
| Willson Contreras (STL) | 0.5 +180 | 0.5 -235 |
| Ryan O'Hearn (BAL) | 0.5 +180 | 0.5 -235 |
| Nolan Arenado (STL) | 0.5 +190 | 0.5 -250 |
Orioles vs Cardinals Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Cade Povich (BAL) | 4.5 -140 | 4.5 +105 |
| Miles Mikolas (STL) | 3.5 -120 | 3.5 -105 |
Cardinals Starting Pitcher Stats & Trends
Opponents batted .225 (89-for-396) against Miles Mikolas with two-strikes in 2023 — highest among qualified SPs in MLB; League Avg: .162 — second Percentile.
Opponents had a two strike miss rate of just 14% (74/529) against Miles Mikolas in the 2024 season — lowest among qualified SPs in MLB; League Avg: 25% — first Percentile.
Miles Mikolas allowed a slugging percentage of .554 (150 Total Bases / 271 ABs) when going through the lineup the second time in a game in the 2024 season — 2nd highest among qualified SPs in MLB; League Avg: .382 — third Percentile.
Opponents are hitting .225 (97-for-432) against Miles Mikolas with two-strikes since last season — 2nd highest among qualified SPs in MLB; League Avg: .161 — fourth Percentile.
Orioles Starting Pitcher Stats & Trends
13 of Cade Povich’s 47 breaking pitch strikeouts (28%) have been backdoor since last season — 4th highest in MLB among starting pitchers with at least 86 total IP; League Avg: 14% — 97th Percentile.
Opponents have a groundball rate of just 10% (2/20) against Cade Povich on inside fastballs this season — lowest in MLB among starting pitchers with at least 21 total IP; League Avg: 42% — 0 Percentile.
Cade Povich has allowed a slugging percentage of .454 (44 Total Bases / 97 ABs) when ahead in the count this season — highest in MLB among starting pitchers with at least 21 total IP; League Avg: .289 — 0 Percentile.
Right-handed hitters had a groundball rate of just 34% (59/175) against Cade Povich in the 2024 season — 6th lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 43% — fourth Percentile.
Cardinals Keys to the Game vs. the Orioles
The Cardinals are just 0-19 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .042.
The Cardinals are 22-14 (.611) when tied entering the 7th inning since last season — 5th best in MLB; League Avg: .499.
The Cardinals are just 10-158 (.060) when trailing entering the 8th inning since the 2023 season — 3rd lowest in MLB; League Avg: .099.
The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.
Orioles Keys to the Game vs. the Cardinals
The Orioles are just 4-15 (.211) after a win this season — 2nd lowest in MLB; League Avg: .512.
The Orioles are just 0-32 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .042.
The Orioles are just 1-28 (.034) when trailing entering the 7th inning this season — 2nd lowest in MLB; League Avg: .132.
The Orioles are 45-15 (.750) when they’ve scored in the first inning since last season — 3rd best in MLB; League Avg: .635.
Cardinals Hitting Stats & Trends
Cardinals hitters have an OBP of .334 (1,495 PA’s) against RHP this season — tied for 4th best in MLB; League Avg: .318.
Cardinals hitters have an OPS of .752 (1,495 PA’s) against RHP this season — 5th best in MLB; League Avg: .718.
The Cardinals are batting .183 on pitches out of the zone this season — best in MLB; League Avg: .148.
The Cardinals have scored first in 75% of their road games this season — highest in MLB; League Avg: 55%.
Orioles Hitting Stats & Trends
Orioles hitters are slugging just .278 against LHP this season — lowest in MLB; League Avg: .377.
Orioles hitters have an OPS of just .557 (523 PA’s) against LHP this season — lowest in MLB; League Avg: .686.
The Orioles are batting just .203 against LHP this season — 2nd lowest in MLB; League Avg: .238.
The Orioles have a winning percentage of just 36% at home this season — 3rd lowest in MLB; League Avg: 56%.
Cardinals Pitching Stats & Trends
Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 25%.
Batters facing the Cardinals pitchers have struck out in the zone 46% of the time since last season — 2nd lowest in MLB; League Avg: 50%. since last season — 2nd lowest in MLB; League Avg: 50%.
Opponents have a miss rate of just 23% against Cardinals pitchers since the 2023 season — 2nd lowest in MLB; League Avg: 25%.
The Cardinals pitchers have allowed their opponents to score first in just 25% of their games on the road this season — lowest in MLB; League Avg: 45%.
Orioles Pitching Stats & Trends
Orioles pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — highest in MLB; League Avg: 8%.
Orioles pitchers have an ERA of 6.17 (226.0 IP) at home this season — highest in MLB; League Avg: 3.81.
Opponents have a miss rate of just 23% against Orioles pitchers this season — 3rd lowest in MLB; League Avg: 25%.
Orioles pitchers have an ERA of 5.50 (471.1 IP) this season — 2nd highest in MLB; League Avg: 4.01.
More MLB Reading:
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