Cardinals vs Pirates Prediction, Odds & Player Prop Bets Today – MLB, Apr 7

Pirates player Andrew McCutchen smiling while running.
(AP Photo/Charles Rex Arbogast)
  • The Cardinals are -125 favorites vs the Pirates
  • Cardinals vs Pirates Over / Under today: 8 Runs
  • Cardinals / Pirates TV Channel: SNPT | FDMX

The St. Louis Cardinals (-125) visit PNC Park to take on the Pittsburgh Pirates (+105) on Monday, April 7, 2025. First pitch is scheduled for 6:40pm EDT in Pittsburgh, PA.

This season, the Cardinals are 4-5 against the spread (ATS), while the Pirates are 3-7 ATS.

Cardinals vs Pirates Starting Pitchers Today:

  • Cardinals starting pitcher: Matthew Liberatore 0-0, 4.50 ERA
  • Pirates starting pitcher: Carmen Mlodzinski 0-1, 9.83 ERA

Cardinals vs. Pirates Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals-1.5 +135O 8 +100-125
Pirates +1.5 -165U 8 -120+105

Cardinals vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Monday‘s MLB game with 53.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Lars Nootbaar has hit the Home Runs Over in 3 of his last 9 away games (+16.90 Units / 188% ROI)
  • Masyn Winn has hit the Runs Over in 13 of his last 15 away games (+13.25 Units / 80% ROI)
  • Nolan Arenado has hit the Hits Over in his last 9 games (+9.00 Units / 46% ROI)
  • Willson Contreras has hit the RBIs Under in 13 of his last 15 away games (+8.30 Units / 26% ROI)
  • Masyn Winn has hit the Hits Runs and RBIs Over in his last 8 away games (+8.25 Units / 89% ROI)

And here are some favorite MLB player prop bets for Pirates players for Monday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

  • Ke’Bryan Hayes has hit the Home Runs Over in 1 of his last 4 games (+9.00 Units / 225% ROI)
  • Oneil Cruz has hit the Hits Runs and RBIs Under in 11 of his last 15 games (+6.45 Units / 33% ROI)
  • Isiah Kiner-Falefa has hit the Total Bases Over in 8 of his last 9 games (+6.25 Units / 41% ROI)
  • Isiah Kiner-Falefa has hit the Hits Over in 8 of his last 9 games (+6.20 Units / 41% ROI)
  • Tommy Pham has hit the Runs Under in his last 6 games (+6.00 Units / 52% ROI)
  • The St. Louis Cardinals have covered the Run Line in 26 of their last 41 games (+9.15 Units / 16% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 22 of their last 37 games (+8.90 Units / 21% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 15 away games (+8.20 Units / 43% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 29 of their last 51 games (+6.75 Units / 12% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 9 of their last 14 away games (+3.45 Units / 20% ROI)
  • The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Over in 38 of their last 64 games at home (+11.60 Units / 16% ROI)
  • The Pittsburgh Pirates have hit the Game Total Over in 16 of their last 25 games at home (+7.05 Units / 25% ROI)
  • The Pittsburgh Pirates have hit the Team Total Under in 12 of their last 17 games (+5.60 Units / 27% ROI)
  • The Pittsburgh Pirates have covered the Run Line in 67 of their last 123 games (+5.40 Units / 3% ROI)
  • The Pittsburgh Pirates have hit the 1st Five Innings (F5) Moneyline in 9 of their last 14 games at home (+3.65 Units / 17% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 5-4 against the Run Line (-0.3 Units / -2.15% ROI).

  • 4-5 when betting on the Moneyline for -2.1 Units / -19.44% ROI
  • 7-1 when betting on the total runs Over for +5.9 Units / 60.51% ROI
  • 1-7 when betting on the total runs Under for -6.85 Units / -68.16% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 3-7 against the Run Line (-4.45 Units / -36.63% ROI).

  • 3-7 when betting on the Moneyline for -4.25 Units / -37.95% ROI
  • 5-5 when betting on the total runs Over for -0.65 Units / -5.75% ROI
  • 5-5 when betting on the total runs Under for -0.35 Units / -3.27% ROI

Pirates vs Cardinals Home Run Prop Bets Today

Over Under
Joey Bart (PIT) 0.5 +550 0.5 -800
Willson Contreras (STL) 0.5 +575 0.5 -900
Andrew McCutchen (PIT) 0.5 +600 0.5 -900
Bryan Reynolds (PIT) 0.5 +650 0.5 -1100
Lars Nootbaar (STL) 0.5 +650 0.5 -1000

Pirates vs Cardinals Total Hits Prop Bets Today

Over Under
Bryan Reynolds (PIT) 0.5 -275 0.5 +200
Brendan Donovan (STL) 0.5 -275 0.5 +195
Lars Nootbaar (STL) 0.5 -250 0.5 +185
Alec Burleson (STL) 0.5 -225 0.5 +170
Nolan Arenado (STL) 0.5 -210 0.5 +155

Pirates vs Cardinals RBI Prop Bets Today

Over Under
Nolan Arenado (STL) 0.5 +160 0.5 -210
Bryan Reynolds (PIT) 0.5 +160 0.5 -210
Joey Bart (PIT) 0.5 +160 0.5 -220
Alec Burleson (STL) 0.5 +165 0.5 -220
Brendan Donovan (STL) 0.5 +165 0.5 -220

Pirates vs Cardinals Strikeout Prop Bets Today

Over Under
Matthew Liberatore (STL) 3.5 -160 3.5 +120
Carmen Mlodzinski (PIT) 3.5 -105 3.5 -120

Matthew Liberatore walked 4 of 138 left-handed batters (3%) in the 2024 season — tied for 7th best among NL Relievers; League Avg: 9% — 93rd Percentile.

Matthew Liberatore walked 4 of 138 left-handed batters (3%) in the 2024 season — 4th best among qualified RPs in MLB; League Avg: 9% — 96th Percentile.

Matthew Liberatore has walked 4 of 140 left-handed batters (3%) since last season — tied for 4th best among qualified RPs in MLB; League Avg: 9% — 97th Percentile.

Matthew Liberatore’s K:BB ratio was 7.8 (31/4) vs left-handed batters in the 2024 season — 4th best among qualified RPs in MLB; League Avg: 2.6 — 96th Percentile.

Pirates Starting Pitcher Stats & Trends

Opponents are hitting just .130 (9-for-69) against Carmen Mlodzinski’s elevated fastball since the 2023 season — 10th best among qualified RPs in MLB; League Avg: .204 — 91st Percentile.

Carmen Mlodzinski has a strikeout rate of just 25% (15 SO in 59 PAs) on low non-fastballs since last season — 8th lowest among NL Relievers; League Avg: 39% — ninth Percentile.

Carmen Mlodzinski has walked 24 of 213 right-handed batters (11%) since the 2023 season — tied for 8th highest among NL Relievers; League Avg: 8% — 11th Percentile.

Opponents are hitting just .105 (4-for-38) against Carmen Mlodzinski’s elevated fastball since last season — 9th best among NL Relievers; League Avg: .200 — 89th Percentile.

Cardinals Keys to the Game vs. the Pirates

The Cardinals are just 10-144 (.065) when trailing entering the 8th inning since last season — 4th lowest in MLB; League Avg: .099.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals are just 49-50 (.495) vs bottom 10 scoring offenses since last season They play the Pirates (24th best runs scored) today.

Pirates Keys to the Game vs. the Cardinals

The Pirates were just 7-44 (.137) when allowing 10 or more hits in the 2024 season — 2nd lowest in MLB; League Avg: .250.

The Pirates were just 65-7 (.903) when leading entering the 9th inning in the 2024 season — 3rd lowest in MLB; League Avg: .949.

The Pirates were just 8-15 (.348) when tied entering the 8th inning in the 2024 season — 4th lowest in MLB; League Avg: .500.

The Pirates were just 10-32 (.238) when their opponents score in the first inning in the 2024 season — 3rd lowest in MLB; League Avg: .359.

The Cardinals have scored 3.22 runs per game (29/9) in late innings this season — best in MLB; League Avg: 1.41.

The Cardinals are batting .224 on pitches out of the zone this season — 2nd best in MLB; League Avg: .146.

The Cardinals are batting .308 on the road this season — best in MLB; League Avg: .224.

Cardinals hitters are slugging .306 on pitches out of the zone this season — 2nd best in MLB; League Avg: .198.

Pirates hitters have 24 strikeouts in 62 PA’s (39%) against LHP this season — tied for highest in MLB; League Avg: 24%.

Pirates hitters are averaging 4.47 pitches per plate appearance against LHP this season — 2nd highest in MLB; League Avg: 3.91.

Pirates hitters are slugging just .361 against RHP since last season — tied for 2nd lowest in MLB; League Avg: .400.

Pirates hitters are slugging just .377 against RHP since the 2023 season — tied for 2nd lowest in MLB; League Avg: .406.

Cardinals pitchers have an ERA of 11.72 (25.1 IP) on the road this season — 2nd highest in MLB; League Avg: 4.67.

The Cardinals have allowed 12.00 runs per game (36/3) on the road this season — tied for highest in MLB; League Avg: 4.84.

Opponents had a miss rate of just 23% against Cardinals pitchers in 2023 — 2nd lowest in MLB; League Avg: 26%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2023 season — 2nd lowest in MLB; League Avg: 26%.

Pirates pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB; League Avg: 43%.

Pirates pitchers have an ERA of 4.51 (1500.0 IP) at home since the 2023 season — 5th highest in MLB; League Avg: 4.09.

Pirates pitchers have allowed a run 34% of the time after an opposing score since the 2023 season — 3rd highest in MLB; League Avg: 31%.

Pirates pitchers have allowed 6 home runs this season — 3rd fewest in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.